Biomaterials for medical and healthcare products

Zahir, Abdul; Mahmood, Urwa; Nazir, Ahsan; Hussain, Tanveer; Abid, Sharjeel

doi:10.1016/b978-0-323-90479-7.00013-0

Cited by 6 publications

(3 citation statements)

References 120 publications

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“…Moreover, metallic NMs such as TiO 2 , Ag, ZnO, and Cu, have applications for surface cleaners and disinfecting agents against COVID-19 [ 60 ]. Due to their superior mechanical, biological, and chemical properties, NMs are used in a variety of medical applications, including tissue engineering, artificial bone grafts, bandages, and electronic medical equipment, particularly dental instruments and vascular stents [ 61 ] as shown in Table 1 .…”

Section: Research Significance Of Nanomaterials In the Biomedical Fieldmentioning

confidence: 99%

A critical review on metal-organic frameworks (MOFs) based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects

Sadiq,

Khan,

Khan

et al. 2024

Heliyon

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Section: Research Significance Of Nanomaterials In the Biomedical Fieldmentioning

confidence: 99%

A critical review on metal-organic frameworks (MOFs) based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects

Sadiq,

Khan,

Khan

et al. 2024

Heliyon

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“…Bioceramics are one of the most practicable materials in bioengineering methods. They are well-known for their oxidation resistance, high mechanical strength, and biocompatibility [118]. Due to their porous structure, they can easily integrate with bone and due to their osteo-inductive properties can be utilized to recover osteochondral defects optimistically [119].…”

Section: Bone-associated Biomaterials Biomolecules and Physical Factorsmentioning

confidence: 99%

Osteochondral organoids: current advances, applications, and upcoming challenges

Faeed,

Ghiasvand,

Fareghzadeh

et al. 2024

Stem Cell Res Ther

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In the realm of studying joint-related diseases, there is a continuous quest for more accurate and representative models. Recently, regenerative medicine and tissue engineering have seen a growing interest in utilizing organoids as powerful tools for studying complex biological systems in vitro. Organoids, three-dimensional structures replicating the architecture and function of organs, provide a unique platform for investigating disease mechanisms, drug responses, and tissue regeneration. The surge in organoid research is fueled by the need for physiologically relevant models to bridge the gap between traditional cell cultures and in vivo studies. Osteochondral organoids have emerged as a promising avenue in this pursuit, offering a better platform to mimic the intricate biological interactions within bone and cartilage. This review explores the significance of osteochondral organoids and the need for their development in advancing our understanding and treatment of bone and cartilage-related diseases. It summarizes osteochondral organoids’ insights and research progress, focusing on their composition, materials, cell sources, and cultivation methods, as well as the concept of organoids on chips and application scenarios. Additionally, we address the limitations and challenges these organoids face, emphasizing the necessity for further research to overcome these obstacles and facilitate orthopedic regeneration.

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“…Simultaneously, the biomaterial should comply with important specific requirements that determine its performance in a particular application. As seen in Figure 2, the most important implant-specific properties can be divided into (a) bulk, (b) chemical and (c) textural properties [47]. The bulk properties can be subdivided into mechanical properties and degradability.…”

Section: Requirements and Generations Of Materials Used For Bone Impl...mentioning

confidence: 99%

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Nikolova

Apostolova

2022

Materials

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To fix the bone in orthopedics, it is almost always necessary to use implants. Metals provide the needed physical and mechanical properties for load-bearing applications. Although widely used as biomedical materials for the replacement of hard tissue, metallic implants still confront challenges, among which the foremost is their low biocompatibility. Some of them also suffer from excessive wear, low corrosion resistance, infections and shielding stress. To address these issues, various coatings have been applied to enhance their in vitro and in vivo performance. When merged with the beneficial properties of various bio-ceramic or polymer coatings remarkable bioactive, osteogenic, antibacterial, or biodegradable composite implants can be created. In this review, bioactive and high-performance coatings for metallic bone implants are systematically reviewed and their biocompatibility is discussed. Updates in coating materials and formulations for metallic implants, as well as their production routes, have been provided. The ways of improving the bioactive coating performance by incorporating bioactive moieties such as growth factors, osteogenic factors, immunomodulatory factors, antibiotics, or other drugs that are locally released in a controlled manner have also been addressed.

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Biomaterials for medical and healthcare products

Cited by 6 publications

References 120 publications

A critical review on metal-organic frameworks (MOFs) based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects

A critical review on metal-organic frameworks (MOFs) based nanomaterials for biomedical applications: Designing, recent trends, challenges, and prospects

Osteochondral organoids: current advances, applications, and upcoming challenges

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

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