Biomaterials for Periodontal Regeneration

Deng, Yuejia; Liang, Yongxi; Liu, Xiaohua

doi:10.1016/j.cden.2022.05.011

Cited by 19 publications

(23 citation statements)

References 74 publications

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“…The current standard for GTR is the biomaterial polytetrafluoroethylene (PTFE), which is a non-absorbable biomaterial with excellent physical and antibacterial attributes. Although it has been reported to show great results in periodontal regeneration, the need for a second surgery may disturb the healing process and increase the risk of infection [ 25 , 26 ]. Even with the improvement of the existing biomaterials, GTR membranes are insufficient to achieve the desired therapeutic results.…”

Section: Biomimetic Biomaterials In Periodontium Regenerationmentioning

confidence: 99%

“…In addition to using cone beam computer tomography (CBCT) scanning, a 3D printed scaffold may be tailored according to the specific needs of patients. Despite its usefulness, the 3D printing technique is limited and cannot be used to create nanoscale scaffolds that match the ECM’s architecture ( Figure 1 ) [ 24 , 25 , 26 ].…”

Section: Biomimetic Biomaterials In Periodontium Regenerationmentioning

confidence: 99%

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Biomimicry and 3D-Printing of Mussel Adhesive Proteins for Regeneration of the Periodontium—A Review

et al. 2023

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Innovation in the healthcare profession to solve complex human problems has always been emulated and based on solutions proven by nature. The conception of different biomimetic materials has allowed for extensive research that spans several fields, including biomechanics, material sciences, and microbiology. Due to the atypical characteristics of these biomaterials, dentistry can benefit from these applications in tissue engineering, regeneration, and replacement. This review highlights an overview of the application of different biomimetic biomaterials in dentistry and discusses the key biomaterials (hydroxyapatite, collagen, polymers) and biomimetic approaches (3D scaffolds, guided bone and tissue regeneration, bioadhesive gels) that have been researched to treat periodontal and peri-implant diseases in both natural dentition and dental implants. Following this, we focus on the recent novel application of mussel adhesive proteins (MAPs) and their appealing adhesive properties, in addition to their key chemical and structural properties that relate to the engineering, regeneration, and replacement of important anatomical structures in the periodontium, such as the periodontal ligament (PDL). We also outline the potential challenges in employing MAPs as a biomimetic biomaterial in dentistry based on the current evidence in the literature. This provides insight into the possible increased functional longevity of natural dentition that can be translated to implant dentistry in the near future. These strategies, paired with 3D printing and its clinical application in natural dentition and implant dentistry, develop the potential of a biomimetic approach to overcoming clinical problems in dentistry.

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Section: Biomimetic Biomaterials In Periodontium Regenerationmentioning

confidence: 99%

Section: Biomimetic Biomaterials In Periodontium Regenerationmentioning

confidence: 99%

Biomimicry and 3D-Printing of Mussel Adhesive Proteins for Regeneration of the Periodontium—A Review

et al. 2023

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“…Because of the high practicability, alloplastic bone grafts such as bioceramics (e.g., absorbable/non-resorbable hydroxyapatite, beta-tricalcium phosphate), bioglasses, metals, calcium phosphate cements and polymers are also of special interest [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Histological and Histomorphometric Evaluation of Implanted Photodynamic Active Biomaterials for Periodontal Bone Regeneration in an Animal Study

Sigusch

Kranz

Hohenberg

et al. 2023

IJMS

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Recently, our group developed two different polymeric biomaterials with photodynamic antimicrobial surface activity for periodontal bone regeneration. The aim of the present study was to analyze the biocompatibility and osseointegration of these materials in vivo. Two biomaterials based on urethane dimethacrylate (BioM1) and tri-armed oligoester-urethane methacrylate (BioM2) that additionally contained ß-tricalcium phosphate and the photosensitizer mTHPC (meso-tetra(hydroxyphenyl)chlorin) were implanted in non-critical size bone defects in the femur (n = 16) and tibia (n = 8) of eight female domestic sheep. Bone specimens were harvested and histomorphometrically analyzed after 12 months. BioM1 degraded to a lower extent which resulted in a mean remnant square size of 17.4 mm², while 12.2 mm² was estimated for BioM2 (p = 0.007). For BioM1, a total percentage of new formed bone by 30.3% was found which was significant higher compared to BioM2 (8.4%, p < 0.001). Furthermore, BioM1 was afflicted by significant lower soft tissue formation (3.3%) as compared to BioM2 (29.5%). Additionally, a bone-to-biomaterial ratio of 81.9% was detected for BioM1, while 8.5% was recorded for BioM2. Implantation of BioM2 caused accumulation of inflammatory cells and led to fibrous encapsulation. BioM1 (photosensitizer-armed urethane dimethacrylate) showed favorable regenerative characteristics and can be recommended for further studies.

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“…GTR involves applying a barrier membrane to cover the periodontal defect, creating a space for the inward migration of PDLSCs and BMSCs, while preventing the ingrowth of undesired GEFs and GFs (Figure B) . The GTR barrier membranes can be divided into nonresorbable and resorbable membranes . While nonabsorbable membranes have sufficient stiffness to maintain space stability, a secondary surgery is necessary to retrieve them, which increases the risk of site morbidity.…”

Section: Introductionmentioning

confidence: 99%

“…While nonabsorbable membranes have sufficient stiffness to maintain space stability, a secondary surgery is necessary to retrieve them, which increases the risk of site morbidity. In addition, nonabsorbable GTR membranes often have high premature exposure rates, leading to significant increases in infection, contamination, and impaired bone augmentation . Absorbable membranes can avoid the need for a second surgery, but their poor mechanical properties make them prone to collapse and displacement.…”

Section: Introductionmentioning

confidence: 99%

E7-Conjugated Bio-Inspired Microspheres as a Biological Barrier for Guided Tissue Regeneration

Hu,

Rong,

Liu

2023

ACS Appl. Mater. Interfaces

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Guided tissue regeneration (GTR), which is based on creating a physical barrier to prevent the downgrowth of epithelial and connective tissues into the defect site, has been widely used in clinical practice for periodontal regeneration for many years. However, its outcomes remain variable due to highly specific indications, the demand for proficient surgical skills, and frequent occurrence of complications. In this study, we developed a new GTR biomaterial that acts as a biological barrier for epithelial cells and fibroblasts while also serving as a scaffold for bone marrow-derived mesenchymal stem cells (BMSCs) and periodontal ligament stem cells (PDLSCs). This innovative GTR biomaterial is bioinspired injectable microspheres that are self-assembled from nanofibers, and their surfaces are conjugated with E7, a short peptide that selectively promotes BMSC and PDLSC adhesion but inhibits the attachment and spreading of epithelial cells and gingival fibroblasts. The selective affinity afforded by E7 on the surfaces of the nanofibrous microspheres facilitated the colonization of BMSCs in the periodontal defect, thereby substantially improving functional periodontal regeneration, as evidenced by enhanced new bone formation, reduced root exposure, and diminished attachment loss. The remarkable superiority of the bioinspired microspheres over conventional GTR materials in promoting periodontal regeneration underscores the potential of this innovative approach to enhance the efficacy of functional periodontal tissue regeneration.

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Biomaterials for Periodontal Regeneration

Cited by 19 publications

References 74 publications

Biomimicry and 3D-Printing of Mussel Adhesive Proteins for Regeneration of the Periodontium—A Review

Biomimicry and 3D-Printing of Mussel Adhesive Proteins for Regeneration of the Periodontium—A Review

Histological and Histomorphometric Evaluation of Implanted Photodynamic Active Biomaterials for Periodontal Bone Regeneration in an Animal Study

E7-Conjugated Bio-Inspired Microspheres as a Biological Barrier for Guided Tissue Regeneration

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