Biomaterials for Treatment of Baldness

Abstract

Androgenic alopecia affects men and women today, where many factors can be the unknown cause of it. It is essential to find a good, effective, and inexpensive treatment for it, as it is a prevalent dermatological condition. Many drugs like minoxidil (MXD) and finasteride (FNS) are commercially used for its treatment but we are still lacking in terms of a complete cure for alopecia. In this study, we came up with different treatment options for alopecia and assessed their advantages and disadvantages. Not only is the treatment part is essential, but the mode of drug delivery is equally important when it comes to hair and its growth for the maximum output. The following discussion considers the idea of nanoparticles (NPs) loaded with drugs and biomaterials used for the treatment of alopecia.

A new easy technique to identify the correct artificial hair implantation site: A case series and preliminary results

“…No pigment was seen although the modifications vary depending on the anatomical structures in the path of the fiber, the inflammatory phenomena were extremely limited and did not produce clinically evident signs of inflammation 17 . Respect of correct patient selection, correct implant procedure, and proper after care is fundamental to avoid prospective problems 22,24,25 . The present artificial hair implant results 26 are very far from the old technique of 80′‐90′ which reported, in some cases, foreign body reactions also causing severe adverse events, including recurrent folliculitis, scalp crusting, scarring, the matting and breakage of fibers, and granulomatous reactions.…”

“…17 Respect of correct patient selection, correct implant procedure, and proper after care is fundamental to avoid prospective problems. 22,24,25 The present artificial hair implant results 26 are very far from the old technique of 80′-90′ which reported, in some cases, foreign body reactions also causing severe adverse events, including recurrent folliculitis, scalp crusting, scarring, the matting and breakage of fibers, and granulomatous reactions. The onset ranged between 1 and 8 weeks of a hyperplastic proliferation of epidermal cells, foreign body granuloma, and persistent acute inflammation due to bacterial infections.…”

Development and characterization of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with finasteride and in vivo evaluation of their efficacy in hair growth

“…It exhibits an enhanced permeability and retention (EPR) effect; this passive targeting of NPs is based on their properties, such as size, shape, and surface charge, which allows them to accumulate in a specific microenvironment, as seen in cancer cells [16]. It is a promising material for drug encapsulation, notably finasteride, since this active ingredient has a high encapsulation efficiency with PLGA, indicating a high interaction between these compounds due to the high degree of lipophilicity of finasteride [19]. This is an efficient way to enhance the bioavailability of this drug, which in turn does not have a long-lasting therapeutic effect due to its low water solubility [20].…”