Biomaterials from Marine‐Origin Biopolymers

Silva, Tiago H.; Duarte, Ana Rita C.; Moreira‐Silva, Joana; Mano, João F.; Reis, Rui L.

doi:10.1002/9783527652273.ch1

Cited by 11 publications

(14 citation statements)

References 185 publications

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“…Marine organisms are a vast source of different compounds with diverse biological properties and bioactivity. Recently, a growing interest in many scientific areas that study the diverse applications of marine compounds has been found, justified by their large biodiversity and simplicity of the extraction and purification processes [ 1 , 2 ]. Marine biomaterials have wide applicability in biomedicine because of their noncytotoxic characteristics, biodegradability and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…Marine biomaterials have wide applicability in biomedicine because of their noncytotoxic characteristics, biodegradability and biocompatibility. These biological properties have allowed the discovery of a broad range of novel bioactive compounds with pharmacological properties and constitute a fundamental cornerstone of the pharmaceutical industry [ 2 , 3 , 4 ]. Some of these compounds have been studied for cancer treatment due to their antitumoral properties [ 5 , 6 , 7 ], among which are polypeptides extracted from tunicates [ 8 ] and sponges [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Marine Origin Polysaccharides in Drug Delivery Systems

2016

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Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications. Marine polysaccharides are among the most abundant materials in the seas, which contributes to a decrease of the extraction costs, besides their solubility behavior in aqueous solvents and extraction media, and their interaction with other biocompounds. Polysaccharides such as alginate, carrageenan and fucoidan can be extracted from algae, whereas chitosan and hyaluronan can be obtained from animal sources. Most marine polysaccharides have important biological properties such as biocompatibility, biodegradability, and anti-inflammatory activity, as well as adhesive and antimicrobial actions. Moreover, they can be modified in order to allow processing them into various shapes and sizes and may exhibit response dependence to external stimuli, such as pH and temperature. Due to these properties, these biomaterials have been studied as raw material for the construction of carrier devices for drugs, including particles, capsules and hydrogels. The devices are designed to achieve a controlled release of therapeutic agents in an attempt to fight against serious diseases, and to be used in advanced therapies, such as gene delivery or regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Marine Origin Polysaccharides in Drug Delivery Systems

2016

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“…In this sense, the sea provides a plentiful resource of potential new products for society including biomaterials. 1,2 In the past decade, comprehensive manuscripts 3 indicate that sponges (Porifera) are the most promising avenue for blue biotechnology, and their leading role within marine biotechnology stems from their long evolutionary history. These sponges are particularly rich in collagen, which is one of the most important and abundant proteins in the human body, with 20 genetically distinct forms known today.…”

Section: ■ Introductionmentioning

confidence: 99%

Water and Carbon Dioxide: Green Solvents for the Extraction of Collagen/Gelatin from Marine Sponges

Barros

Aroso

Silva

et al. 2015

ACS Sustainable Chem. Eng.

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Marine sponges are extremely rich in natural products and are considered a promising biological resource. The major objective of this work is to couple a green extraction process with a natural origin raw material to obtain sponge origin collagen/gelatin for biomedical applications. Marine sponge collagen has unique physicochemical properties, but its application is hindered by the lack of availability due to inefficient extraction methodologies. Traditional extraction methods are time consuming as they involve several operating steps and large amounts of solvents. In this work, we propose a new extraction methodology under mild operating conditions in which water is acidified with carbon dioxide (CO 2) to promote the extraction of collagen/gelatin from different marine sponge species. An extraction yield of approximately 50% of collagen/gelatin was achieved. The results of Fourier transformed infrared spectroscopy (FTIR), circular dichroism (CD), and differential scanning calorimetry (DSC) spectra suggest a mixture of collagen/gelatin with high purity, and the analysis of the amino acid composition has shown similarities with collagen from other marine sources. Additionally, in vitro cytotoxicity studies did not demonstrate any toxicity effects for three of the extracts.

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“…It is present in the cell wall of brown algae, playing not only a structural function but also being involved in ionic exchange mechanisms. Alginate is an unbranched polysaccharide composed of β(1-4)-linked D-mannuronic acid (M) and α(1-4)-linked L-guluronic acid (G) ( Figure 2), which are stereoisomers and differ in the composition of the carboxyl group [1,43]. M and G units can be present in blocks of (M and G) or mixed (MG) [1].…”

Section: Alginatementioning

confidence: 99%

Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

et al. 2020

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Marine resources have considerable potential to develop high-value materials for applications in different fields, namely pharmaceutical, environmental, and biomedical. Despite that, the lack of solubility of marine-derived polymers in water and common organic solvents could restrict their applications. In the last years, ionic liquids (ILs) have emerged as platforms able to overcome those drawbacks, opening many routes to enlarge the use of marine-derived polymers as biomaterials, among other applications. From this perspective, ILs can be used as an efficient extraction media for polysaccharides from marine microalgae and wastes (e.g., crab shells, squid, and skeletons) or as solvents to process them in different shapes, such as films, hydrogels, nano/microparticles, and scaffolds. The resulting architectures can be applied in wound repair, bone regeneration, or gene and drug delivery systems. This review is focused on the recent research on the applications of ILs as processing platforms of biomaterials derived from marine polymers.

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Biomaterials from Marine‐Origin Biopolymers

Cited by 11 publications

References 185 publications

Marine Origin Polysaccharides in Drug Delivery Systems

Marine Origin Polysaccharides in Drug Delivery Systems

Water and Carbon Dioxide: Green Solvents for the Extraction of Collagen/Gelatin from Marine Sponges

Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

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