Biomaterials in Orthopedics

Yaszemski, Michael J.; Trantolo, Debra J.; Lewandrowski, Kai‐Uwe; Hasırcı, Vasıf; Altobelli, David E.; Wise, Donald

doi:10.1201/9780203913086

Cited by 42 publications

(32 citation statements)

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“…The characteristic peaks at 0.99 ppm and 1.25 ppm for methyl group for valerate and hydroxybutyrate monomers, respectively, can be used to determine the valeric composition in the copolymer PHBV sample according to equation 1 [27,28]: [1] It was confirmed that PHBV has 19 mol% of the monomer HV. The presence of this monomer decreases the polymer crystallinity and, thus, its mechanical properties change (high elastic modulus and flexural strength with low tensile strength and elongation at break) [29] and degradability [30]. Such different properties directly influence the features of the coatings with both polymers.…”

Section: Biopolymer Characterizationmentioning

confidence: 99%

Antibacterial PHAs coating for titanium implants

Rodríguez-Contreras

García

Manero

et al. 2017

European Polymer Journal

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Biomaterial-associated infection is a serious complication of modern implantation surgery.Thus, the improvement of implant surfaces is required to avoid the first stage for biofilm formation, bacterial adhesion. The current research addresses this issue by developing drug delivery systems (DDS) consisting of antibiotic-loaded polyhydroxyalkanoates (PHAs) coatings on titanium implants. Dip-coating technique was used to achieve optimal coatings with biodegradable biopolyesters, polyhydroxybutyrate (PHB) and its copolymer, polyhydroxybutyrate-co-hydroxyvalerate (PHBV). The coatings were completely characterized (wettability, topography, thickness and roughness), and studies of drug delivery, toxicity, antibacterial effect, and cell adhesion were performed. For both of biopolymers, surfaces were partially covered with 1 and 3 immersions, while with 6, they were completely covered. Although both antibiotic-loaded biopolymer coatings assure the protection against bacteria populations, PHBV coatings are closer to the desired release profile; its faster degradation provides for a greater and more stable drug release for a given period of time compared to PHB coatings. The use of coatings with different drug concentration per layer results in more controlled and homogeneous releases. The DDS designed not only assure toavoid the first stage of bacterial adhesion, but also their proliferation and biofilm formation, since the coatings degrade with time under physiological conditions, guaranteeing a prolonged drug release.

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Section: Biopolymer Characterizationmentioning

confidence: 99%

Antibacterial PHAs coating for titanium implants

Rodríguez-Contreras

García

Manero

et al. 2017

European Polymer Journal

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“…zirconia and hydroxyapatite have been incorporated as reinforcing fillers. A frequent processing route that is followed in the polymer industry and is often specifically used in medical or dental applications is to fabricate the multiphase composites by using various types of fillers or dispersing agents [25][26][27][28]. By incorporating the supplementary reinforcement into the matrix resin, a synergistic effect may be achieved in terms of improvements in mechanical, thermal and biological properties.…”

Section: Introductionmentioning

confidence: 99%

The improvement of mechanical and thermal properties of polyamide 12 3D printed parts by fused deposition modelling

Rahim¹,

Abdullah²,

Akil³

et al. 2017

Express Polym. Lett.

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Abstract. This paper addresses the utilisation of fused deposition modelling (FDM) technology using polyamide 12, incorporated with bioceramic fillers (i.e. zirconia and hydroxyapatite) as a candidate for biomedical applications. The entire production process of printed PA12 is described, starting with compounding, filament wire fabrication and finally, FDM printing. The potential to process PA12 using this technique and mechanical, thermal and morphological properties were also examined. Commonly, a reduction of mechanical properties of printed parts would occur in comparison with injection moulded parts despite using the same material. Therefore, the mechanical properties of the samples prepared by injection moulding were also measured and applied as a benchmark to examine the effect of different processing methods. The results indicated that the addition of fillers improved or maintained the strength and stiffness of neat PA12, at the expense of reduced toughness and flexibility. Melting behaviours of PA12 were virtually insensitive to the processing techniques and were dependent on additional fillers and the cooling rate. Incorporation of fillers slightly lowered the melting temperature, however improved the thermal stability. In summary, PA12 composites were found to perform well with FDM technique and enabling the production of medical implants with acceptable mechanical performances for non-load bearing applications.

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“…Currently, the most widely used metallic biomaterials for biomedical applications are 316L stainless steel and the Ti-6Al-4V alloy 5 . Although the Ti-6Al-4V has a lower modulus of elasticity (112 GPa) 5 than stainless steel 316L (210 GPa) 6 , this value is still very high compared with the elastic modulus of bone (cortical bone -15-30 GPa) 6 . Also, some studies have indicated that long-term cytotoxic effects may arise with vanadium and that aluminum may be associated with neurological disorders.…”

Section: Introductionmentioning

confidence: 99%

“…Niobium is nontoxic, nonllergenic, and exhibits high biocompatibility; it also promotes a reduction in the elastic modulus 9,11 , increases corrosion resistance, and improves the biological properties of the alloy. Niobium also exerts a high β stabilizing effect 6 . The equilibrium phase diagram of Ti-Nb alloy 12 is isomorphic type, without any reaction or transformation invariant matching.…”

Section: Introductionmentioning

confidence: 99%

Influence of the substitutional solute on the mechanical properties of Ti-Nb binary alloys for biomedical use

et al. 2012

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Titanium alloys are widely used in the manufacture of biomedical implants because they possess an excellent combination of physical properties and outstanding biocompatibility. Today, the most widely used alloy is Ti-6Al-4V, but some studies have reported adverse effects with the long-term presence of Al and V in the body, without mentioning that the elasticity modulus value of this alloy is far superior to the bone. Thus, there is a need to develop new Ti-based alloys without Al and V that have a lower modulus, greater biocompatibility, and similar mechanical strength. In this paper, we investigated the effect of Nb as a substitutional solute on the mechanical properties of Ti-Nb alloys, prepared in an arc-melting furnace and characterized by density, X-ray diffraction, optical microscopy, hardness and elasticity modulus measurements. The X-ray and microscopy measurements show a predominance of the α phase. The microhardness values showed a tendency to increase with the concentration of niobium in the alloy. Regarding the elasticity modulus, it was observed a nonlinear behavior with respect to the concentration of niobium. This behavior is associated with the presence of the α phase.

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Biomaterials in Orthopedics

Cited by 42 publications

References 0 publications

Antibacterial PHAs coating for titanium implants

Antibacterial PHAs coating for titanium implants

The improvement of mechanical and thermal properties of polyamide 12 3D printed parts by fused deposition modelling

Influence of the substitutional solute on the mechanical properties of Ti-Nb binary alloys for biomedical use

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