Biomaterials in treatment of Alzheimer's disease

Agrawal, Mukta; E, Venkata Prathyusha; Ahmed, Hafiz; Dubey, Sunil Kumar; Kesharwani, Prashant; Singhvi, Gautam; Naidu, V.G.M.; Alexander, Amit

doi:10.1016/j.neuint.2021.105008

Cited by 55 publications

(21 citation statements)

References 121 publications

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“…[ 5 , 6 ] Hydrogel administration methods include intranasal administration, microneedle patch, subcutaneous injection, or intracranial injection. [ 9 , 10 , 11 , 12 ] At present, intranasal administration is mostly used in the treatment of AD by hydrogel technology. Intranasal administration is a new method of administration, which can make drugs bypass the blood–brain barrier (BBB) and reach the brain quickly through the cerebral nerve (trigeminal nerve or olfactory nerve) pathway.…”

Section: Application Of Hydrogel In the Treatment Of Admentioning

confidence: 99%

Hydrogel: A promising new technique for treating Alzheimer’s disease

Gong

Cheng

Wen-bo

et al. 2022

Journal of Translational Internal Medicine

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Section: Application Of Hydrogel In the Treatment Of Admentioning

confidence: 99%

Hydrogel: A promising new technique for treating Alzheimer’s disease

Gong

Cheng

Wen-bo

et al. 2022

Journal of Translational Internal Medicine

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“…Available treatments and diagnostics for AD and other dementias are limited, given the challenges drug carriers must address crossing the blood‐brain barrier while also maintaining therapeutic properties. [ 265 ] Hydrogels and hydrogel nanocomposites have been shown to effectively target drug delivery to the brain and have potential to be used as therapeutic treatments and diagnostic AD marker detection tools. In recent years, the nasal passage has been the most prominently studied approach for administration of brain drug delivery for treatment and diagnosis of AD.…”

Section: Treating Diseases Resulting From Chronic Exposure To Environ...mentioning

confidence: 99%

Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment

Gutiérrez

Frazar

Klaus

et al. 2021

Adv Healthcare Materials

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Humans are constantly exposed to exogenous chemicals throughout their life, which can lead to a multitude of negative health impacts. Advanced materials can play a key role in preventing or mitigating these impacts through a wide variety of applications. The tunable properties of hydrogels and hydrogel nanocomposites (e.g., swelling behavior, biocompatibility, stimuli responsiveness, functionality, etc.) have deemed them ideal platforms for removal of environmental contaminants, detoxification, and reduction of body burden from exogenous chemical exposures for prevention of disease initiation, and advanced treatment of chronic diseases, including cancer, diabetes, and cardiovascular disease. In this review, three main junctures where the use of hydrogel and hydrogel nanocomposite materials can intervene to positively impact human health are highlighted: 1) preventing exposures to environmental contaminants, 2) prophylactic treatments to prevent chronic disease initiation, and 3) treating chronic diseases after they have developed.

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“…The physiological state of the brain is quite different to that of other organs because the BBB is a primary obstacle for drug delivery to the brain [25,26]. For this reason, various delivery platforms have been investigated to improve the penetration and/or transport of bioactive agents [26][27][28][29][30][31][32][33][34][35][36][41][42][43][44][45][46][47]. For example, surfactants such as polysorbate 80 have been used to allow nanoparticles or drug carriers to penetrate the BBB [41][42][43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

“…Nano-dimensional carriers such as nanoparticles, liposomes, peptide-drugs and/or polymeric drugs have been investigated for the improvement of drug delivery across the BBB [27][28][29][30]. Nano-dimensional carriers are characterized by small particle sizes, diversity of customized form, ease of lipophilic drug encapsulation, increased half lives in the body, and targeting of the drug to specific sites of action [31].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Oxidative Stress and Memantine-Incorporated Reactive Oxygen Species-Sensitive Nanoparticles on the Expression of N-Methyl-d-aspartate Receptor Subunit 1 in Brain Cancer Cells for Alzheimer’s Disease Application

Kim

Jeong

2021

IJMS

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The aim of this study is to fabricate reactive oxygen species (ROS)-sensitive nanoparticles composed of succinyl β-cyclodextrin (bCDsu), memantine and thioketal linkages for application in Alzheimer’s disease, and to investigate the suppression of N-methyl-d-aspartate (NMDA) receptor 1 (NMDAR1) in cells. Thioketal diamine was attached to the carboxyl group of bCDsu to produce thioketal-decorated bCDsu conjugates (bCDsu-thioketal conjugates) and memantine was conjugated with thioketal dicarboxylic acid (memantine-thioketal carboxylic acid conjugates). Memantine-thioketal carboxylic acid conjugates were attached to bCDsu-thioketal conjugates to produce bCDsu-thioketal-memantine (bCDsuMema) conjugates. SH-SY5Y neuroblastoma cells and U87MG cells were used for NMDAR1 protein expression and cellular oxidative stress. Nanoparticles of bCDsuMema conjugates were prepared by means of a dialysis procedure. Nanoparticles of bCDsuMema conjugates had small particle sizes less than 100 nm and their morphology was found to be spherical in transmission electron microscopy observations (TEM). Nanoparticles of bCDsuMema conjugates responded to H2O2 and disintegrated or swelled in aqueous solution. Then, the nanoparticles rapidly released memantine according to the concentration of H2O2. In an in vivo animal imaging study, thioketal-decorated nanoparticles labelled with fluorescent dye such as chlorin e6 (Ce6) showed that the fluorescence intensity was stronger in the brain than in other organs, indicating that bCDsuMema nanoparticles can efficiently target the brain. When cells were exposed to H2O2, the viability of cells was time-dependently decreased. Memantine or bCDsuMema nanoparticles did not practically affect the viability of the cells. Furthermore, a western blot assay showed that the oxidative stress produced in cells using H2O2 increased the expression of NMDAR1 protein in both SH-SY5Y and U87MG cells. Memantine or bCDsuMema nanoparticles efficiently suppressed the NMDAR1 protein, which is deeply associated with Alzheimer’s disease. Fluorescence microscopy also showed that H2O2 treatment induced green fluorescence intensity, which represents intracellular ROS levels. Furthermore, H2O2 treatment increased the red fluorescence intensity, which represents the NMDAR1 protein, i.e., oxidative stress increases the expression of NMDAR1 protein level in both SH-SY5Y and U87MG cells. When memantine or bCDsuMema nanoparticles were treated in cells, the oxidative stress-mediated expression of NMDAR1 protein in cells was significantly decreased, indicating that bCDsuMema nanoparticles have the capacity to suppress NMDAR1 expression in brain cells, which has relevance in terms of applications in Alzheimer’s disease.

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Biomaterials in treatment of Alzheimer's disease

Cited by 55 publications

References 121 publications

Hydrogel: A promising new technique for treating Alzheimer’s disease

Hydrogel: A promising new technique for treating Alzheimer’s disease

Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment

The Effect of Oxidative Stress and Memantine-Incorporated Reactive Oxygen Species-Sensitive Nanoparticles on the Expression of N-Methyl-d-aspartate Receptor Subunit 1 in Brain Cancer Cells for Alzheimer’s Disease Application

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