Biomaterials Used As Bone Graft subtitutes

Narang, Sumit; Chava, Vijay Kumar

doi:10.22452/adum.vol7no1.7

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…For the DBM, the ground bone was placed in 0.5 M hydrochloric acid at 4°C on a shaker for 64 hours to remove the mineral phase. 21 The demineralized bone was repeatedly washed in sterile double-distilled water and PBS, then sterile water again before being lyophilized overnight. Porous bTCP granules (GenOs) were obtained (Orthos, Bristol, United Kingdom).…”

Section: Bone Graft Materialsmentioning

confidence: 99%

Interaction of Platelet-Rich Concentrate With Bone Graft Materials: An In Vitro Study

Butcher

Milner²,

Ellis³

et al. 2009

Journal of Orthopaedic Trauma

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Section: Bone Graft Materialsmentioning

confidence: 99%

Interaction of Platelet-Rich Concentrate With Bone Graft Materials: An In Vitro Study

Butcher

Milner²,

Ellis³

et al. 2009

Journal of Orthopaedic Trauma

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“…21 The demineralized bone was repeatedly washed in sterile double-distilled water and PBS, then sterile water again before being lyophilized overnight. The bone fragments were extensively washed in sterile double-distilled water with vigorous agitation before being ground using a mortar and pestle.…”

Section: Bone Graft Materialsmentioning

confidence: 99%

Invited Commentary

Lane¹

2009

Journal of Orthopaedic Trauma

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Objective: Platelet-rich concentrate (PRC) is in routine use for orthopaedic and maxilofacial surgery and is frequently combined with bone graft materials to fill bony defects and enhance healing. Numerous studies have been performed investigating the efficacy of PRC to enhance bone healing in which a variety of graft materials have been combined with varying degrees of success. Here, we sought to determine the effect of combining PRC with different graft materials on human bone marrow stromal cell (hBMSC) proliferation, osteoblastic differentiation, and bone formation.Methods: Our central hypothesis is that PRC is not a true osteogenic agent but rather is osteopromotive, with cell fate determination being dependent on additional signals derived from the microenvironment. Experiments were performed with low passage (maximum 3) hBMSCs that were maintained in the presence of ascorbic acid-2-phosphate and beta-glycerol phosphate. Dexamethasone was excluded from these studies. PRC and graft materials were retained within well inserts and clotted by addition of bovine thrombin. Cell proliferation was determined by DNA content, osteoblastic commitment, and differentiation by alkaline phosphatase activity and matrix mineralization.Results: Combining PRC with the graft materials increased proliferation above that seen with the graft materials alone; however, only demineralized bone matrix (DBM) and allograft were capable of increasing proliferation above that seen with PRC alone. The increased proliferation observed in the presence of PRC coincided with decreased normalized alkaline phosphatase activity, suggesting decreased osteoblastic differentiation. However, at later time points, PRC increased mineralization compared with DBM, collagen, or beta tricalcium phosphate alone. When compared with PRC alone, addition of DBM or allograft decreased mineralization. Collagen gave rise to a small increase in mineralization, whereas beta tricalcium phosphate yielded the same level of mineralization as PRC alone. Conclusions:The data obtained from these in vitro investigations demonstrate that the cellular responses induced by PRC and bone graft materials in hBMSC can be significantly (positively or negatively) modified by adding the agents in combination. These in vitro data highlight the need to consider the potential interaction between biologic agents when added in combination.

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“…On the other hand, biomaterials can be described as materials that are biocompatible, nontoxic, biodegradable, or nondegradable when in contact with biological systems (Ha et al, 2013). Biomaterials can be used as medical devices in many areas such as dentistry (Tuna et al, 2017), orthopedics (Navarro et al, 2008), vascular implants (Ravi & Chaikof, 2010), spinal implants (Warburton et al, 2020), bone graft (Narang & Chava, 2000), any ophthalmic implants (Allan, 1999). In recent years, the production of LC‐based biomaterials gain importance, especially in the application of self‐assembled nanostructures, drug delivery (Dinarvand et al, 2006), and vascular implants (Hussain et al, 2021), as well as the skeletal muscles (Buguin et al, 2006), and these biomaterials can be mimicked by LC‐based polymers by means of their anisotropic structures (Iwabata et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Liquid crystal‐based elastomers in tissue engineering

Gürboğa

Tuncgovde

Kemiklioğlu

2022

Biotech & Bioengineering

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Liquid crystal elastomers (LCEs) play role in tissue engineering investigations, with the combination of orientational ordering generated by liquid crystal (LC) moieties and the elastic capabilities of polymers. Liquid crystal‐based polymer materials require a thorough understanding of their features that set them apart from other smart materials for proper design and application. LCEs offer many advantages for their widespread use in the field of biomaterials, by virtue of their simplicity of processing, anisotropic behavior, and responding to numerous external stimuli. Especially, LCEs have widespread usage in bioengineering applications such as scaffolds due to their biocompatibility, viability, and proliferation properties of these materials. This study introduces a brief overview of the new areas of liquid crystal‐based elastomer applications combining both biomaterials and engineering.

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Biomaterials Used As Bone Graft subtitutes

Cited by 3 publications

References 5 publications

Interaction of Platelet-Rich Concentrate With Bone Graft Materials: An In Vitro Study

Interaction of Platelet-Rich Concentrate With Bone Graft Materials: An In Vitro Study

Invited Commentary

Liquid crystal‐based elastomers in tissue engineering

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