Biomaterials Used in Orthopedic Implants

Güner, Ali Tekin; Meran, Cemal

doi:10.5505/pajes.2019.46666

Cited by 11 publications

(3 citation statements)

References 83 publications

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“…The first study in Türkiye about the biology of thermal springs was from Pamukkale (Regel and Skuja 1937), and there are other studies on the algal flora of the Pamukkale thermal spring (Güner 1966, Pentecost et al 1997, Altunöz et al 2016. Also, Aysel et al (1992) examined cyanobacteria in the Ilıksu thermal springs (Zonguldak, Türkiye) and reported 33 Cyanobacteria taxa.…”

Section: Introductionmentioning

confidence: 99%

The taxonomy and distribution of algae in the thermal springs of Türkiye

Öztürk,

Kurt

2024

Acta bot. Croat. (Online)

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The algal flora and physio-chemical parameters of seven thermal springs in Denizli were studied for the first time. Samples for algal analyses were taken monthly between May 2013 and June 2014, while the physio-chemical parameters were measured seasonally. The mean pH value of the thermal springs was 6.3, and temperatures varied between 34-60 °C. The significant differences (P < 0.001) among the thermal springs were in their temperature and pH, as well as concentration of Cl^- , Fe^2+ , K^+ , Mg^+ , Na^+ , Li^+ , Ca^+ , HCO3^ - , and SO4^2- ions. A total of 43 Cyanobacteria and three Bacillariophyta taxa were determined.The most common taxon was Spirulina subsalsa Oersted ex Gomont, sampled from five sampling sites. According to the principal component analysis (PCA), the most important determining factor for the algae was temperature, followed by concentration of K^+ and Cl^- ions.

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Section: Introductionmentioning

confidence: 99%

The taxonomy and distribution of algae in the thermal springs of Türkiye

Öztürk,

Kurt

2024

Acta bot. Croat. (Online)

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“…[ 2 ] The biomaterials of orthopedic implant devices must have the characteristics of good safety, high strength, good biocompatibility, mechanical properties similar to those of bone, good machinability, and wear resistance. [ 3 ] At present, the main materials involved in orthopedics can be divided into three categories: metal, bioceramics and polymers. Medical metals are the most widely used implant materials at present, but their elastic modulus is much higher than that of bone, and there are problems such as stress shielding, bone resorption, and bone collapse.…”

Section: Introductionmentioning

confidence: 99%

Engineering Multifunctional Polyether Ether Ketone Implant: Mechanics‐Adaptability, Biominerialization, Immunoregulation, Anti‐Infection, Osteointegration, and Osteogenesis

Hao

Zhao

et al. 2023

Adv Healthcare Materials

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Polyether ether ketone (PEEK) has become one of the most promising polymer implants in bone orthopedics, due to the biocompatibility, good processability, and radiation resistance. However, the poor mechanics‐adaptability/osteointegration/osteogenesis/antiinfection limits the long‐term in vivo applications of PEEK implants. Herein, a multifunctional PEEK implant (PEEK‐PDA‐BGNs) is constructed through in situ surface deposition of polydopamine‐bioactive glass nanoparticles (PDA‐BGNs). PEEK‐PDA‐BGNs exhibit good performance on osteointegration and osteogenesis in vitro and in vivo, due to their multifunctional properties including mechanics‐adaptability, biominerialization, immunoregulation, anti‐infection, and osteoinductive activity. PEEK‐PDA‐BGNs can show the bone tissue‐adaptable mechanic surface and induce the rapid biomineralization (apatite formation) under a simulated body solution. Additionally, PEEK‐PDA‐BGNs can induce the M2 phenotype polarization of macrophages, reduce the expression of inflammatory factors, promote the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and improve the osseointegration and osteogenesis ability of the PEEK implant. PEEK‐PDA‐BGNs also show good photothermal antibacterial activity and can kill 99% of Escherichia coli (E. coli) and Methicillin‐resistant Staphylococcus aureus (MRSA), suggesting their potential antiinfection ability. This work suggests that PDA‐BGNs coating is probably a facile strategy to construct multifunctional (biomineralization, antibacterial, immunoregulation) implants for bone tissue replacement.

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“…Corrosion is also another problem in addition to stay in the body permanently with metal implants. Biocompatible metal alloys are frequently used in joint and bone implants due to their good physical properties such as high strength, toughness, and ductility [2]. However, the stress transfer problem caused by the high modulus of elasticity of metal alloy biomaterials [3,4] leading to osteoporosis [5] and the need for a secondary operation for removal are among the disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Pla/Ha Composite Material Production and Mechanical Characterization for Temporary Implant Applications

Çelik,

Saraçoğlu,

Özkan

et al. 2023

IJPTE

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Hard tissues in the human body are damaged due to age, trauma, and bone diseases. Metal implants/prostheses are traditionally preferred to repair and treat these damaged tissues. Today, metals and their alloys meet the mechanical requirements of the musculoskeletal system well. However, the need to develop alternative composite materials has increased since metals are very stiff materials compared to bone. Problems such as stress shielding, and aseptic loosening can arise due to their high modulus of elasticity, and the need for secondary revision operations for such reasons. Also, the metal implant/prostheses should be removed after the healing that causes the undesirable secondary operation. In this study, polylactic acid (PLA) and hydroxyapatite (HA)-based composite materials were produced and their mechanical characteristics evaluated for possible implant applications. In addition, the PLA/HA composite materials stayed in Artificial Body Fluid (ABF) at different times, and the change in the mechanical properties were determined. PLA granules and HA powders were mixed in different ratios of weight (weight ratio 1:0, 9:1, 7:3, and 1:1) to produce 80 samples using the solvent casting technique. PLA was dissolved with chloroform in a magnetic stirrer at 200 rpm and room temperature, and then nano HA was added and mixed until homogeneity was achieved. After casting and drying, the samples were cut into appropriate standard sizes. The samples were subjected to biodegradability in-vitro test. In the results of this study, the modulus of elasticity increased with the increase of HA in the samples; however, the yield strength, ultimate strength, and yield strain of the samples decreased. In addition, it was observed that the existence of HA decreases the rate of degradation; therefore, the percentage of weakening in mechanical strength decreased in the measurements made at the end of the 15th day. According to these results, it was concluded that PLA/HA biodegradable composites can be developed to use as implant/prosthesis material.

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Biomaterials Used in Orthopedic Implants

Cited by 11 publications

References 83 publications

The taxonomy and distribution of algae in the thermal springs of Türkiye

The taxonomy and distribution of algae in the thermal springs of Türkiye

Engineering Multifunctional Polyether Ether Ketone Implant: Mechanics‐Adaptability, Biominerialization, Immunoregulation, Anti‐Infection, Osteointegration, and Osteogenesis

Biodegradable Pla/Ha Composite Material Production and Mechanical Characterization for Temporary Implant Applications

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