Biomechanical evaluation of cornea in patients with ankylosing spondylitis

Çağlayan, Mehtap; Saraç, Özge; Kösekahya, Pınar; Erten, Şükran; Ayan, Berna; Çağıl, Nurullah

doi:10.1007/s10792-016-0368-3

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…While previous views held that KCN is primarily a noninflammatory disease, there is increasing evidence to confirm the role of ocular and systemic inflammation in its pathogenesis and progression [ 17 ]. Prior studies emphasize additional overlap between KCN and AS by depicting how AS induces corneal biomechanical changes similar to those seen in KCN, characterized by decreases in corneal thickness, stiffness, and hysteresis [ 14 , 18 , 19 ]. This knowledge may allow providers to consider appropriate coinvolvement of corneal, uveitis, and systemic specialists when clinical and laboratory findings are present.…”

Section: Discussionmentioning

confidence: 99%

Acute Anterior Uveitis with HLA-B27 Positivity after Corneal Cross-Linking with Previous Intrastromal Corneal Ring Segment

Khan

McGuffey

Melson

et al. 2022

Case Reports in Ophthalmological Medicine

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Purpose. To describe a case of acute anterior uveitis (AAU) with HLA-B27 positivity following epithelium-off corneal cross-linking (CXL) in a patient with a previous intrastromal corneal ring segment. Observations. A 28-year-old male with keratoconus (KCN) developed ophthalmalgia, perilimbal injection, hypopyon, and decline in corrected distance visual acuity (CDVA) 3 days after CXL. A working diagnosis of inflammatory versus infectious AAU was made, and the patient was treated with topical tobramycin, polymyxin B/trimethoprim, prednisolone, and oral valacyclovir. Clinical appearance and CDVA improved, ultimately returning to baseline by two weeks postoperatively. Diagnostic laboratory workup revealed HLA-B27 positivity. Conclusions and Importance. A comprehensive laboratory workup is helpful to identify potential causative and associated systemic conditions when encountering AAU after CXL. Given the overlap in patient demographics for KCN and HLA-B27 positivity, clinicians should consider this entity in the differential diagnosis and treatment of such cases.

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