Biomechanical Measurements of Calcium‐Incorporated Oxidized Implants in Rabbit Bone: Effect of Calcium Surface Chemistry of a Novel Implant

Sul, Young‐Taeg; Byon, Eungsun; Jeong, Yongsoo

doi:10.1111/j.1708-8208.2004.tb00032.x

Cited by 66 publications

(69 citation statements)

References 21 publications

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“…titanium (Skripitz & Aspenberg 1998) and hydroxyapatite-coated implants (Edwards et al 1997). Our recent series of investigations on anionincorporated (sulphur or phosphorus) and cationincorporated (calcium or magnesium) titanium implants indirectly verified biochemical bonds in animal models (Sul 2003;Sul et al 2004Sul et al , 2005Sul et al , 2006Sul et al , 2008.…”

Section: Introductionmentioning

confidence: 91%

A novel in vivo method for quantifying the interfacial biochemical bond strength of bone implants

Sul

Johansson

Albrektsson

2009

J. R. Soc. Interface.

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Quantifying the in vivo interfacial biochemical bond strength of bone implants is a biological challenge. We have developed a new and novel in vivo method to identify an interfacial biochemical bond in bone implants and to measure its bonding strength. This method, named biochemical bond measurement (BBM), involves a combination of the implant devices to measure true interfacial bond strength and surface property controls, and thus enables the contributions of mechanical interlocking and biochemical bonding to be distinguished from the measured strength values. We applied the BBM method to a rabbit model, and observed great differences in bone integration between the oxygen (control group) and magnesium (test group) plasma immersion ion-implanted titanium implants (0.046 versus 0.086 MPa, nZ10, pZ0.005). The biochemical bond in the test implants resulted in superior interfacial behaviour of the implants to bone: (i) close contact to approximately 2 mm thin amorphous interfacial tissue, (ii) pronounced mineralization of the interfacial tissue, (iii) rapid bone healing in contact, and (iv) strong integration to bone. The BBM method can be applied to in vivo experimental models not only to validate the presence of a biochemical bond at the bone-implant interface but also to measure the relative quantity of biochemical bond strength. The present study may provide new avenues for better understanding the role of a biochemical bond involved in the integration of bone implants.

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Section: Introductionmentioning

confidence: 91%

A novel in vivo method for quantifying the interfacial biochemical bond strength of bone implants

Sul

Johansson

Albrektsson

2009

J. R. Soc. Interface.

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“…The healing periods used by various authors for assessing the bone implant contact in rabbits are 2, 3, 4, 6, 8, and 12 weeks [53–57]. However, the best results have been between 6 and 12 weeks of insertion period [51, 53–55]. The 6-week healing period was carefully chosen after literature search.…”

Section: Discussionmentioning

confidence: 99%

Osseointegration of standard and mini dental implants: a histomorphometric comparison

et al. 2017

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“…It is well documented that protein adsorption and cell attachment are improved by HA coating with bioactive materials 44,45) . It has also been suggested that biochemical bonding by electrostatic bonds is possible between the interface of bone tissue and the calcium of calcium-incorporated implants 46) . A number of studies on in vitro protein adsorption suggest that calcium possibly provides a bridge between titanium and macromolecules 47,48) .…”

Section: Discussionmentioning

confidence: 99%

Enhanced biological responses of a hydroxyapatite/TiO<Sub>2</Sub> hybrid structure when surface electric charge is controlled using radiofrequency sputtering

et al. 2012

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We investigated whether surface roughness and control of surface electric charge of a hydroxyapatite (HA)/titanium oxide (TiO2) hybrid coating could enhance biological responses associated with bone formation. After acid etching, a titanium surface was modified with HA and TiO2 by the dual sputtering deposition technique using radiofrequency sputtering. These surfaces were analyzed for surface roughness and surface electric charge intensity. Rat bone marrow-derived osteoblast-like cells were cultured on HA/TiO2 hybrid surfaces with different electric charges. The attachment and spreading behavior of these cells were significantly increased on the hybrid surface (p<0.05). In vivo experiment, the strength of bone-titanium implant integration with a hybrid surface was 3 times that of a control (p<0.05). The dual sputtering deposition technique created a HA/TiO2 hybrid structure. Our results show that the surface electric charge on a titanium surface is an important factor for enhancing biological responses.

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Biomechanical Measurements of Calcium‐Incorporated Oxidized Implants in Rabbit Bone: Effect of Calcium Surface Chemistry of a Novel Implant

Cited by 66 publications

References 21 publications

A novel in vivo method for quantifying the interfacial biochemical bond strength of bone implants

A novel in vivo method for quantifying the interfacial biochemical bond strength of bone implants

Osseointegration of standard and mini dental implants: a histomorphometric comparison

Enhanced biological responses of a hydroxyapatite/TiO<Sub>2</Sub> hybrid structure when surface electric charge is controlled using radiofrequency sputtering

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