Biomechanical properties and microstructure of human ventricular myocardium

Sommer, Gerhard; Schriefl, Andreas Jörg; Andrä, Michaela; Sacherer, Michael; Viertler, Christian; Wolinski, Heimo; Holzapfel, Gerhard

doi:10.1016/j.actbio.2015.06.031

Cited by 234 publications

(274 citation statements)

References 81 publications

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“…10 A combination of biaxial extension data and triaxial shear data at different orientations is required to capture the direction-dependent nonlinear anisotropic material response. 10 Recently, Sommer et al 24 conducted biaxial extension and triaxial shear tests on human ventricular myocardium. Their study suggests that the passive human left ventricular myocardium exhibits nonlinear, orthotropic, viscoelastic, and history-dependent behavior.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical Properties and Microstructure of Heart Chambers: A Paired Comparison Study in an Ovine Model

2016

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Mechanical properties of the cardiac tissue play an important role in normal heart function. The goal of this study was to determine the passive mechanical properties of all heart chambers through a paired comparison study in an ovine model. Ovine heart was used due its physiological and anatomical similarities to human heart. A total of 189 specimens from anterior and posterior portions of the left and right ventricles, atria, and appendages underwent biaxial mechanical testing. A Fung-type strain energy function was used to fit the experimental data. Tissue behavior was quantified based on the magnitude of strain energy, as indicator of tissue stiffness, at equibiaxial strains of 0.10, 0.15, and 0.20. Statistical analysis revealed no significant difference in strain energy storage between anterior and posterior portions of each chamber, except for the right ventricle where strain energy storage in the posterior specimens were higher than the anterior specimens. Additionally, all chambers from the left side of the heart had significantly higher strain energy storage than the corresponding chambers on the right side. Furthermore, the highest to lowest stored strain energy were associated with ventricles, appendages, and atria, respectively. Microstructure of tissue specimens from different chambers was also compared using histology.

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Section: Discussionmentioning

confidence: 99%

Biomechanical Properties and Microstructure of Heart Chambers: A Paired Comparison Study in an Ovine Model

2016

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“…Over the past decade, several investigations have been carried out to determine the stress-strain distribution in porcine hearts, as well as in other small and big animal hearts including the human heart (Kichula et al, 2014, Sommer et al, 2015. However, most of these studies have focused on one region only, namely, the LV (Nikou et al, 2016, Wise et al, 2016.…”

Section: Discussionmentioning

confidence: 99%

Biaxial quantification of passive porcine myocardium elastic properties by region

Ṋemavhola¹

2017

10.5267/j.esm

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Considering accurate constitutive models is of the utmost importance when capturing the mechanical response of soft tissue and biomedical materials under physiological loading conditions. This paper investigated the behaviour of porcine myocardium in passive rested hearts. This was done by applying biaxial loads on the myocardium. The main objective of this research was to investigate the cardiac mechanics of various regions of a healthy passive rested porcine heart. The biaxial mechanical properties of myocardial tissue samples were captured using a biaxial testing system. The porcine heart was divided into three regions, namely, left ventricle (LV), septum and right ventricle (RV). In these regions, 18 × 18 mm2 equal samples were cut from six porcine passive hearts. For the LV sample, the biaxial elastic modulus in the fibre direction was 33.3% larger than in the cross fibre direction, for the mid-wall sample it was 18.8% larger, and for the RV sample it was 33.3% larger. It was concluded that the cardiac mechanics of LV, septum and RV exhibit mechanical behaviour that differs considerably. In developing adequate computational models, these data could be applied to estimate the material parameters of the myocardium.

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“…where 3, c, 3 I , 3 , c I , c , 3 I and c I are eight positive material constants which can be derived from [22]. The given strain energy function consists of an isotropic term in , a transversely isotropic term in lI and l and an orthotropic term in oI .…”

Section: Discussionmentioning

confidence: 99%

“…Different from the electrophysiological models electromechanical models are still in a maturing phase. Magnetic resonance imaging makes it now possible to create patient-specific highly resolved anatomical models [13], ventricle muscle fiber directions can be determined and assigned with a rule-based algorithm [19] and the orthotropic electric [20] and mechanical properties [21,22] of the ventricular myocardium are well studied. However, there are still many tasks towards a highly sophisticated whole heart computer model.…”

Section: Introductionmentioning

confidence: 99%