Biomechanical testing of a PEEK-based dynamic instrumentation device in a lumbar spine model

Herren, Christian; Beckmann, Agnes; Meyer, Sabine; Pishnamaz, Miguel; Mundt, Marion; Sobottke, Rolf; Prescher, Andreas; Stoffel, Marcus; Markert, Bernd; Kobbe, Philipp; Pape, Hans-Christian; Eysel, Peer; Siewe, Jan

doi:10.1016/j.clinbiomech.2017.03.009

Cited by 19 publications

(25 citation statements)

References 31 publications

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“…This model provides defect region with controllable dynamic stimulation and also enlighten us the mechanism of mechanical signal transmission and the relationship between physiological and mechanical‐induced regeneration. (Herren et al, ).…”

Section: Discussionmentioning

confidence: 99%

Novel standardized massive bone defect model in rats employing an internal eight‐hole stainless steel plate for bone tissue engineering

Jiang

Cheng

et al. 2018

J Tissue Eng Regen Med

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Massive bone defects are a challenge in orthopaedic research. Defective regeneration leads to bone atrophy, non-union of bone, and physical morbidity. Large animals are important models, however, production costs are high, nursing is complex, and evaluation methods are limited. A suitable laboratory animal model is required to explore the underlying molecular mechanism and cellular process of bone tissue engineering. We designed a stainless steel plate with 8 holes; the middle 2 holes were used as a guide to create a standardized critical size defect in the femur of anaesthetized rats. The plate was fixed to the bone using 6 screws, serving as an inner fixed bracket to secure a tricalcium phosphate implant seeded with green fluorescent protein-positive rat bone marrow mesenchymal stem cells within the defect. In some animals, we also grafted a vessel bundle into the lateral side of the implant, to promote vascularized bone tissue engineering. X-ray, microcomputed tomography, and histological analyses demonstrated the stainless steel plate resulted in a stable large segmental defect model in the rat femur. Vascularization significantly increased bone formation and implant degradation. Moreover, survival and expansion of green fluorescent protein-positive seeded cells could be clearly monitored in vivo at 1, 4, and 8 weeks postoperation via fluorescent microscopy. This standardized large segmental defect model in a small animal may help to advance the study of bone tissue engineering. Furthermore, availability of antibodies and genetically modified rats could help to dissect the precise cellular and molecular mechanisms of bone repair.

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Section: Discussionmentioning

confidence: 99%

Novel standardized massive bone defect model in rats employing an internal eight‐hole stainless steel plate for bone tissue engineering

Jiang

Cheng

et al. 2018

J Tissue Eng Regen Med

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“…To simulate the loading of a gait cycle, rotational angles in three directions were applied to the instrumented model. However, the ROM of the instrumented spine are significantly reduced compared to the native spine when loaded by the same moment [1]. Therefore, two simulations were conducted to simulate a worst case and a best case scenario for the PDSD.…”

Section: Methodsmentioning

confidence: 99%

“…For validating the instrumented spine model, the simulated ROM was compared to the experimental ROM of the instrumented cadaveric spine specimen (Tab. 2) [1]. To simulate the loading of a gait cycle, rotational angles in three directions were applied to the instrumented model.…”

Section: Methodsmentioning

confidence: 99%

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Assessment of the high‐cycle fatigue performance of a PEEK‐based spinal dynamic instrumentation using numerical simulation and experimental data

Beckmann

Markert

et al. 2017

Proc Appl Math and Mech

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A lumbar spine model with a PDSD was created using CT data and validated with experimental results of the same specimen. The material parameters of the spine and the stabilisation device were taken from literature and calibrated using experimental data. A fatigue model accounting for notch effect and cyclic plastic deformation was used to predict the fatigue life of the device regarding high-cycle loading and material softening of PEEK.

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“…Consequently, posterior dynamic stabilization systems (PDSSs) with reduced stiffness were developed. The PDSS aims to maintain the healthy biomechanics of the spine by preventing the hypermobility of a mildly degenerated disc or after a decompression surgery, as well as preventing the onset of an adjacent segment disease (Fujiwara et al, 2000;Herren et al, 2017;Krismer et al, 2000;Lee et al, 2014;Tanaka et al, 2001). Clinical studies can be found in the literature, in which a successful stabilization of the treated segment is reported (Lee et al, 2014;Lee et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Biomechanical testing of a polycarbonate-urethane-based dynamic instrumentation system under physiological conditions

Beckmann

Herren

Nicolini

et al. 2019

Clinical Biomechanics

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Biomechanical testing of a PEEK-based dynamic instrumentation device in a lumbar spine model

Cited by 19 publications

References 31 publications

Novel standardized massive bone defect model in rats employing an internal eight‐hole stainless steel plate for bone tissue engineering

Novel standardized massive bone defect model in rats employing an internal eight‐hole stainless steel plate for bone tissue engineering

Assessment of the high‐cycle fatigue performance of a PEEK‐based spinal dynamic instrumentation using numerical simulation and experimental data

Biomechanical testing of a polycarbonate-urethane-based dynamic instrumentation system under physiological conditions

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