Biomechanical Tissue Characterization of the Superior Joint Space of the Porcine Temporomandibular Joint

Kim, Kyoung-Won; Wong, Mark E.; Helfrick, John F.; Thomas, James B.; Athanasiou, Kyriacos A.

doi:10.1114/1.1591190

Cited by 79 publications

(93 citation statements)

References 25 publications

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“…First, flushing the joints with PBS was performed to ensure a consistent testing environment, although this condition differs from that in vivo. Second, the mixed background of the tested animals likely increased variability and discouraged detection of regional differences previously reported in the literature (Kim et al 2003;Lu et al 2009). Nevertheless, greater variability improves generalization of results.…”

Section: Discussionmentioning

confidence: 99%

Role of Interstitial Fluid Pressurization in TMJ Lubrication

et al. 2014

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In temporomandibular joints (TMJs), the disc and condylar cartilage function as load-bearing, shock-absorbing, and frictionreducing materials. The ultrastructure of the TMJ disc and cartilage is different from that of hyaline cartilage in other diarthrodial joints, and little is known about their lubrication mechanisms. In this study, we performed micro-tribometry testing on the TMJ disc and condylar cartilage to obtain their region-and direction-dependent friction properties. Frictional tests with a migrating contact area were performed on 8 adult porcine TMJs at 5 different regions (anterior, posterior, central, medial, and lateral) in 2 orthogonal directions (anterior-posterior and medial-lateral). Some significant regional differences were detected, and the lateral-medial direction showed higher friction than the anterior-posterior direction on both tissues. The mean friction coefficient of condylar cartilage against steel was 0.027, but the disc, at 0.074, displayed a significantly higher friction coefficient. The 2 tissues also exhibited different frictional dependencies on sliding speed and normal loading force. Whereas the friction of condylar cartilage decreased with increased sliding speed and was independent of the magnitude of normal force, friction of the disc showed no dependence on sliding speed but decreased as normal force increased. Further analysis of the Péclet number and frictional coefficients suggested that condylar cartilage relies on interstitial fluid pressurization to a greater extent than the corresponding contact area of the TMJ disc.

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Section: Discussionmentioning

confidence: 99%

Role of Interstitial Fluid Pressurization in TMJ Lubrication

et al. 2014

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“…Tensile strength and stiffness correlate with local collagen orientation, with greater values present in the central region when tested in the anteroposterior direction relative to the mediolateral direction (Shengyi and Xu, 1991;Beatty et al, 2001;Detamore and Athanasiou, 2003b). Compressive properties vary topographically; the relaxation modulus of the medial region is highest, while the posterior and anterior bands appear to support the highest instantaneous loads (del Pozo et al, 2002;Kim et al, 2003;Athanasiou, 2005, 2006a). Overall, the disc is 10 to 1000 times softer under compression than it is under tension (Tanaka and van Eijden, 2003).…”

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An Interspecies Comparison of the Temporomandibular Joint Disc

et al. 2010

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A supplemental appendix to this article is published electronically only at http://jdr.sagepub.com/Appendix. ABSTRACTThe temporomandibular joint (TMJ) disc plays a critical role in normal function of the joint, and many disorders of the TMJ are a result of disc dysfunction. Previous quantitative TMJ characterization studies examined either the human or a specific animal model, but no single study has compared different species, in the belief that differences in joint morphology, function, and diet would be reflected in the material properties of the disc. In this study, we examined topographical biochemical (collagen, glycosaminoglycan, and DNA content) and biomechanical (tensile and compressive) properties of the human TMJ disc, and also discs from the cow, goat, pig, and rabbit. Regional and interspecies variations were identified in all parameters measured, and certain disc characteristics were observed across all species, such as a weak intermediate zone under mediolateral tension. While human discs possessed properties distinct from those of the other species, pig discs were most similar to the human, suggesting that the pig may be a suitable animal model for TMJ bioengineering efforts.

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“…31,32 Vertical deformation (DL) required to produce this strain was calculated using the strain equation, e ¼ DL=L 0 with the measured height (L 0 ) known from earlier measurement. The resulting compressive stress on each sample is defined by r ¼ F Z =A, where F Z is the compressive force and A is the cross-sectional area of the sample.…”

Section: Biomechanical Analysismentioning

confidence: 99%

Engineered Microporosity: Enhancing the Early Regenerative Potential of Decellularized Temporomandibular Joint Discs

Juran

Dolwick

McFetridge

2015

Tissue Engineering Part A

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The temporomandibular joint (TMJ) disc is susceptible to numerous pathologies that may lead to structural degradation and jaw dysfunction. The limited treatment options and debilitating nature of severe temporomandibular disorders has been the primary driving force for the introduction and development of TMJ disc tissue engineering as an approach to alleviate this important clinical issue. This study aimed to evaluate the efficacy of laser micropatterning (LMP) ex vivo-derived TMJ disc scaffolds to enhance cellular integration, a major limitation to the development of whole tissue implant technology. LMP was incorporated into the decellularized extracellular matrix scaffold structure using a 40 W CO 2 laser ablation system to drill an 8 · 16 pattern with a bore diameter of 120 mm through the scaffold thickness. Disc scaffolds were seeded with human neonatal-derived umbilical cord mesenchymal stem cells differentiated into chondrocytes at a density of 900 cells per mm 2 and then assessed on days 1, 7, 14, and 21 of culture. Results derived from histology, PicoGreen DNA quantification, and cellular metabolism assays indicate that the LMP scaffolds improve cellular remodeling compared to the unworked scaffold over the 21-day culture period. Mechanical analysis further supports the use of the LMP showing the compressive properties of the LMP constructs closely represent native disc mechanics. The addition of an artificial path of infiltration by LMP culminated in improved chondrocyte adhesion, dispersion, and migration after extended culture aiding in recapitulating the native TMJ disc characteristics.

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Biomechanical Tissue Characterization of the Superior Joint Space of the Porcine Temporomandibular Joint

Cited by 79 publications

References 25 publications

Role of Interstitial Fluid Pressurization in TMJ Lubrication

Role of Interstitial Fluid Pressurization in TMJ Lubrication

An Interspecies Comparison of the Temporomandibular Joint Disc

Engineered Microporosity: Enhancing the Early Regenerative Potential of Decellularized Temporomandibular Joint Discs

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