Biomechanically stimulated chondrocytes promote osteoclastic bone resorption in the mandibular condyle

Bin, Kuang; Zeng, Zhaobin; Qin, Qing

doi:10.1016/j.archoralbio.2018.12.002

Cited by 14 publications

(10 citation statements)

References 24 publications

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“…When chondrocytes were stimulated mechanically, they produced more pro-osteoclastic factors, such as transforming growth factor 1 (TGF-1), which increased condylar subchondral bone resorption by boosting osteoclastogenesis. These findings back up the theory that cartilage alterations occur before subchondral bone modificas, and so play a key role in mechanical loading [ 23 ].…”

Section: Introductionsupporting

confidence: 61%

Evaluation of the Multiple Tissue Factors in the Cartilage of Primary and Secondary Rhinoplasty in Cleft Lip and Palate Patients

2022

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Cleft lip and palate (CLP) is one of the craniofacial defects. The objective of this study was to identify the differences in appearance between the tissue factors in cartilage of CLP patients after primary and secondary rhinoplasty. Immunohistochemistry was performed with MMP-2, MMP-8, MMP-9, TIMP-2, IL-1α, IL-10, bFGF, and TGFβ1. The quantification of the structures was performed using a semi-quantitative census method. MMP-2, -9, IL-1a, and bFGF demonstrated higher number of positive cells in patients, while the number of MMP-8, IL-1a, -10 and TGFβ1 cells was higher or equal in the control subjects. The only statistically significant difference between CLP-operated patients was found in the TIMP-2 group, where the primary CLP patient group had a higher number of TIMP-2 positive chondrocytes than the secondary CLP patient group (U = 53.5; p = 0.021). The median value of the primary CLP group was ++ number of TIMP-2 positive chondrocytes compared to +++ in the secondary CLP group. No statistically significant difference was found between primary and secondary rhinoplasty patients for other tissue factors. Commonly, the rich expression of different tissue factors suggests a stimulation of higher elasticity in cleft affected cartilage. The statistically significant TIMP-2 elevation in primary operated cartilage indicates an impact of the selective tissue remodeling for hard tissue.

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Section: Introductionsupporting

confidence: 61%

Evaluation of the Multiple Tissue Factors in the Cartilage of Primary and Secondary Rhinoplasty in Cleft Lip and Palate Patients

2022

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“…2). Previous studies have shown that the left and right condylar processes are different from each other in the unilateral splint models or functional lateral shift models (Kure-Hattori et al, 2012;Sato et al, 2006;Wattanachai et al, 2009). In the current study, based on the results from the gross appearance, most of the changes were observed in the condylar process ipsilateral to the splint, manifested by the flattening of the lateral region.…”

Section: W LI Et Al Splints and Tmj Remodelingsupporting

confidence: 45%

“…Therefore, future studies should also be conducted to investigate the recovery of the condylar process following the fitting of bite-altering splints. In addition to the changes to the condylar process, it has been reported that the glenoid fossa is remodeled in a rat molar splint (resin + metal crown) model (Liu et al, 2007). In the current study, changes happened to the glenoid fossa were not investigated, but it would be worthwhile to study the remodeling of the glenoid fossa together with the condylar process to gain a better understanding of how the splint will affect the structure and function of the TMJ as a whole.…”

Section: W LI Et Al Splints and Tmj Remodelingmentioning

confidence: 95%

Mandibular condylar process remodeling in rats with different bite-altering devices

Li¹,

Trbojevic²,

Pineda-Farias³

et al. 2022

eCM

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The objective was to compare different dental splint models and materials for inducing abnormal loading on the gross morphology and histological appearance of the mandibular condylar processes of Sprague Dawley rats. Three different types of dental splints (resin molar, aluminum incisor, stainless-steel incisor) were placed unilaterally to induce occlusal perturbation for 4 weeks. At that time, mandibular condylar processes were assessed by gross appearance and histology. Quantitative measurements were also conducted on the hematoxylin & eosin images for condyle shape. The results showed that although the condylar cartilage was affected by all splint types, the resin molar splint was associated with the most extensive mandibular condylar process remodeling, which was primarily a slant (skewness) of the lateral aspect of the condylar process. Additionally, quantitative measurements on the histological specimens demonstrated that the split and tilt angle of the left (ipsilateral) condylar processes in the resin molar group (124.8 ± 12.7° and 104.1 ± 12.7°, respectively) increased significantly (p < 0.05) when compared to right (contralateral) condylar processes (104.7 ± 5.8°and 91.6 ± 4.4°, respectively). However, no changes were noted on the thickness of the fibrocartilage layer at medial, central, and lateral regions of the condylar process. Another major finding is the high variability of morphology of the naïve animals. Future studies will assess the impact of longer durations of splinting, age, and sex on the remodeling of the mandibular condylar process, allowing for the development of diagnostics and therapies.

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“…However, excessive FSS (>12 dyn/cm 2 ) can promote matrix degradation, inhibit chondrocyte phenotype synthesis, and lead to cartilage degeneration. Therefore, appropriate FSS intensity should be maintained when applying mechanical stimulation 173–175 …”

Section: Anti‐angiogenesis Strategies In Tissue Engineeringmentioning

confidence: 99%

Mechanisms of vascular invasion after cartilage injury and potential engineering cartilage treatment strategies

Zhao,

Sun,

et al. 2024

The FASEB Journal

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Articular cartilage injury is one of the most common diseases in orthopedic clinics. Following an articular cartilage injury, an inability to resist vascular invasion can result in cartilage calcification by newly formed blood vessels. This process ultimately leads to the loss of joint function, significantly impacting the patient's quality of life. As a result, developing anti‐angiogenic methods to repair damaged cartilage has become a popular research topic. Despite this, tissue engineering, as an anti‐angiogenic strategy in cartilage injury repair, has not yet been adequately investigated. This exhaustive literature review mainly focused on the process and mechanism of vascular invasion in articular cartilage injury repair and summarized the major regulatory factors and signaling pathways affecting angiogenesis in the process of cartilage injury. We aimed to discuss several potential methods for engineering cartilage repair with anti‐angiogenic strategies. Three anti‐angiogenic tissue engineering methods were identified, including administering angiogenesis inhibitors, applying scaffolds to manage angiogenesis, and utilizing in vitro bioreactors to enhance the therapeutic properties of cultured chondrocytes. The advantages and disadvantages of each strategy were also analyzed. By exploring these anti‐angiogenic tissue engineering methods, we hope to provide guidance for researchers in related fields for future research and development in cartilage repair.

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Biomechanically stimulated chondrocytes promote osteoclastic bone resorption in the mandibular condyle

Cited by 14 publications

References 24 publications

Evaluation of the Multiple Tissue Factors in the Cartilage of Primary and Secondary Rhinoplasty in Cleft Lip and Palate Patients

Evaluation of the Multiple Tissue Factors in the Cartilage of Primary and Secondary Rhinoplasty in Cleft Lip and Palate Patients

Mandibular condylar process remodeling in rats with different bite-altering devices

Mechanisms of vascular invasion after cartilage injury and potential engineering cartilage treatment strategies

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