Biomechanics and Biocompatibility of Woven Spider Silk Meshes During Remodeling in a Rodent Fascia Replacement Model

Schäfer-Nolte, Franziska; Hennecke, Kathleen; Reimers, Kerstin; Schnabel, Reinhild; Allmeling, Christina; Vogt, Peter M.; Kuhbier, Joern W.; Mirastschijski, Ursula

doi:10.1097/sla.0b013e3182917677

Cited by 51 publications

(33 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, these issues have been resolved and relatively large amounts of spider silk can be harvested. The use of native spider silk has been successfully established as a biomaterial for nerve regeneration and other biomedical applications [47,48,61,62,63,64,65,66,67,68]. As a first step for the development of a spider silk-based nerve conduit, a breeding station for spiders of the genera Nephila clavipes was build and processing parameters of native spider silk were established.…”

Section: The Development Of a Spider Silk/acellularized Vein-basedmentioning

confidence: 99%

Natural Occurring Silks and Their Analogues as Materials for Nerve Conduits

Radtke

2016

IJMS

View full text Add to dashboard Cite

Spider silk and its synthetic derivatives have a light weight in combination with good strength and elasticity. Their high cytocompatibility and low immunogenicity make them well suited for biomaterial products such as nerve conduits. Silk proteins slowly degrade enzymatically in vivo, thus allowing for an initial therapeutic effect such as in nerve scaffolding to facilitate endogenous repair processes, and then are removed. Silks are biopolymers naturally produced by many species of arthropods including spiders, caterpillars and mites. The silk fibers are secreted by the labial gland of the larvae of some orders of Holometabola (insects with pupa) or the spinnerets of spiders. The majority of studies using silks for biomedical applications use materials from silkworms or spiders, mostly of the genus Nephila clavipes. Silk is one of the most promising biomaterials with effects not only in nerve regeneration, but in a number of regenerative applications. The development of silks for human biomedical applications is of high scientific and clinical interest. Biomaterials in use for biomedical applications have to meet a number of requirements such as biocompatibility and elicitation of no more than a minor inflammatory response, biodegradability in a reasonable time and specific structural properties. Here we present the current status in the field of silk-based conduit development for nerve repair and discuss current advances with regard to potential clinical transfer of an implantable nerve conduit for enhancement of nerve regeneration.

show abstract

Section: The Development Of a Spider Silk/acellularized Vein-basedmentioning

confidence: 99%

Natural Occurring Silks and Their Analogues as Materials for Nerve Conduits

Radtke

2016

IJMS

View full text Add to dashboard Cite

show abstract

“…However, a reported negative immune response (mainly due to the presence of remnant sericin, which normally acts as a natural lubricant secreted by the worm, around the silk fibers) and the poor biocompatibility of worm‐derived silk, have instigated the extraction of silk fibers from other biological sources . For instance, spider silk dragline is another potential source of natural fibers for tissue engineering applications . Contrary to silk extracted from worms, spider silk is readily implantable after sterilization as it is not sericin‐coated.…”

Section: Biologically Derived Matricesmentioning

confidence: 99%

“…Preliminary experiments performed on spider silk revealed a complete degradation 4 months after implantation in rats. In addition, more giant cells surrounding silk mesh were denoted compared to other commercial meshes (Ultrapro from Ethicon or Surgisis) but gradually vanished, along with the disappearance of the biomaterial, to create a collagenous scar in the wounded area . As natural silk is rather heterogeneous regarding mechanical and biological behaviors depending on the studied species (i.e., there are 44,540 known spider species), the production of engineered‐silks using transgenic organisms (bacteria or worms with enhanced performance offers remarkable advances and warrants more interest for the future manufacturing of hernia meshes.…”

Section: Biologically Derived Matricesmentioning

confidence: 99%

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio‐Functionality to Meshes

Guillaume

Teuschl

Gruber-Blum

et al. 2015

Adv Healthcare Materials

View full text Add to dashboard Cite

Abdominal wall hernia is a recurrent issue world-wide and requires the implantation of over 1 million meshes per year. Because permanent meshes such as polypropylene and polyester are not free of complications after implantation, many mesh modifications and new functionalities have been investigated over the last decade. Indeed, mesh optimization is the focus of intense development and the biomaterials utilized are now envisioned as being bioactive substrates that trigger various physiological processes in order to prevent complications and to promote tissue integration. In this context, it is of paramount interest to review the most relevant bio-functionalities being brought to new meshes and to open new avenues for the innovative development of the next generation of meshes with enhanced properties for functional abdominal wall hernia repair.

show abstract

“…Researchers have also fabricated mesh prostheses using silk proteins isolated from both worms and spiders. Silk derived from worms has been shown to produce various immune responses and is considered to be less biocompatible than spider silk due to a lack of natural lubricant coatings [88, 89]. …”

Section: Introductionmentioning

confidence: 99%

Design strategies and applications of biomaterials and devices for Hernia repair

Kalaba

Gerhard

Winder

et al. 2016

Bioactive Materials

118

128

View full text Add to dashboard Cite

Hernia repair is one of the most commonly performed surgical procedures worldwide, with a multi-billion dollar global market. Implant design remains a critical challenge for the successful repair and prevention of recurrent hernias, and despite significant progress, there is no ideal mesh for every surgery. This review summarizes the evolution of prostheses design toward successful hernia repair beginning with a description of the anatomy of the disease and the classifications of hernias. Next, the major milestones in implant design are discussed. Commonly encountered complications and strategies to minimize these adverse effects are described, followed by a thorough description of the implant characteristics necessary for successful repair. Finally, available implants are categorized and their advantages and limitations are elucidated, including non-absorbable and absorbable (synthetic and biologically derived) prostheses, composite prostheses, and coated prostheses. This review not only summarizes the state of the art in hernia repair, but also suggests future research directions toward improved hernia repair utilizing novel materials and fabrication methods.

show abstract

Biomechanics and Biocompatibility of Woven Spider Silk Meshes During Remodeling in a Rodent Fascia Replacement Model

Abstract: Hand-manufactured spider silk meshes with good biocompatibility and beneficial mechanical properties seem superior to standard biological and synthetic meshes, implying an innovative alternative to currently used meshes for hernia repair.

Cited by 51 publications

References 53 publications

Natural Occurring Silks and Their Analogues as Materials for Nerve Conduits

Natural Occurring Silks and Their Analogues as Materials for Nerve Conduits

Emerging Trends in Abdominal Wall Reinforcement: Bringing Bio‐Functionality to Meshes

Design strategies and applications of biomaterials and devices for Hernia repair

Contact Info

Product

Resources

About