2023
DOI: 10.1038/s41467-023-36682-y
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Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish

Abstract: Land-walking vertebrates maintain a desirable posture by finely controlling muscles. It is unclear whether fish also finely control posture in the water. Here, we showed that larval zebrafish have fine posture control. When roll-tilted, fish recovered their upright posture using a reflex behavior, which was a slight body bend near the swim bladder. The vestibular-induced body bend produces a misalignment between gravity and buoyancy, generating a moment of force that recovers the upright posture. We identified… Show more

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Cited by 20 publications
(33 citation statements)
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“…However, new neurons are few in the adult, indicating that new hair cells regenerated in mature fish are likely innervated by preexisting neurons (Schwarzer et al, 2020). Synapse formation and regeneration has been studied extensively in the lateral line, where hair cells and their synapses are easily accessible on the external surface of the fish (Lush and Piotrowski, 2014;Pujol-Martí et al, 2014;Suli et al, 2016;Hardy et al, 2021;Holmgren et al, 2021). Here, functional hair cell/afferent synapses have been shown to depend on a complex interaction of calcium influx through voltage-gated channels, mitochondria, and synaptic ribbons in the pre-and postsynaptic densities (Sheets et al, 2011;Sheets et al, 2012;Wong et al, 2019).…”
Section: First-order Vestibular Neuronsmentioning
confidence: 99%
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“…However, new neurons are few in the adult, indicating that new hair cells regenerated in mature fish are likely innervated by preexisting neurons (Schwarzer et al, 2020). Synapse formation and regeneration has been studied extensively in the lateral line, where hair cells and their synapses are easily accessible on the external surface of the fish (Lush and Piotrowski, 2014;Pujol-Martí et al, 2014;Suli et al, 2016;Hardy et al, 2021;Holmgren et al, 2021). Here, functional hair cell/afferent synapses have been shown to depend on a complex interaction of calcium influx through voltage-gated channels, mitochondria, and synaptic ribbons in the pre-and postsynaptic densities (Sheets et al, 2011;Sheets et al, 2012;Wong et al, 2019).…”
Section: First-order Vestibular Neuronsmentioning
confidence: 99%
“…(C) The vestibulospinal (VS) circuit also primarily receives input from the medial utricle, and in greatest proportion from ES hair cells and sends projections to MC, TN, and lateral vestibular nuclei (LVN). These VS neurons project to the longitudinal fasciculus or straight down the spinal cord, where motoneurons are activated and posture stabilization initializes (Hamling et al, 2021;Liu et al, 2022;Sugioka et al, 2023).…”
Section: Much Of Recent Work Has Focused On Circuit Development and F...mentioning
confidence: 99%
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