As form follows function, pedal anatomy is embedded in a history of evolution. This literature review seeks to further the understanding of physiologic and pathologic flatfoot through cross-disciplinary research of expired and extant members of the Homininae subfamily. Archaeological, anthropological, paleontological, and ontogenetic evidence presents multiple biomechanical similarities and anatomical parallels between flatfooted hominins and humans. Recognizing an evolutionary pattern in flatfoot pathologic disorders enhances anticipation and effective treatment.