Biomechanics and regulation of external respiration under conditions of five-day dry immersion

Popova, Yu. A.; Суворов, А. В.; Dyachenko, A. I.; Колесников, В. И.

doi:10.1134/s0362119713070153

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Studies of respiratory function have shown an increase of respiratory resistance, greater inspiratory and reduced expiratory reserve volumes, as well as changes in the thoracic-abdominal ratio in breathing motions and shifts in voluntary respiration regulation (Dyachenko et al, 2010; Mikhailovskaya et al, 2011; Popova et al, 2011). In addition, increased amplitude of breathing motions with reduced frequency has been noted, together with distinct breathing-related heart rate fluctuations (Semenov et al, 2011).…”

Section: Effects On the Cardiorespiratory Systemmentioning

confidence: 99%

Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

et al. 2019

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Dry immersion (DI) is one of the most widely used ground models of microgravity. DI accurately and rapidly reproduces most of physiological effects of short-term space flights. The model simulates such factors of space flight as lack of support, mechanical and axial unloading as well as physical inactivity. The current manuscript gathers the results of physiological studies performed from the time of the model’s development. This review describes the changes induced by DI of different duration (from few hours to 56 days) in the neuromuscular, sensory-motor, cardiorespiratory, digestive and excretory, and immune systems, as well as in the metabolism and hemodynamics. DI reproduces practically the full spectrum of changes in the body systems during the exposure to microgravity. The numerous publications from Russian researchers, which until present were mostly inaccessible for scientists from other countries are summarized in this work. These data demonstrated and validated DI as a ground-based model for simulation of physiological effects of weightlessness. The magnitude and rate of physiological changes during DI makes this method advantageous as compared with other ground-based microgravity models. The actual and potential uses of the model are discussed in the context of fundamental studies and applications for Earth medicine.

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Section: Effects On the Cardiorespiratory Systemmentioning

confidence: 99%

Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

et al. 2019

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“…Hypocapnia is known to reduce CBF by decreasing CPP and decreasing CVR (Grüne et al, 2015). However, breathing function seems to be not altered in DI (Popova et al, 2013).…”

Section: Nonspecific Factors That May Influence Rcbfmentioning

confidence: 99%

Reduced Regional Cerebral Blood Flow Measured by 99mTc-Hexamethyl Propylene Amine Oxime Single-Photon Emission Computed Tomography in Microgravity Simulated by 5-Day Dry Immersion

et al. 2021

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Microgravity induces a cephalad fluid shift that is responsible for cephalic venous stasis that may increase intracranial pressure (ICP) in astronauts. However, the effects of microgravity on regional cerebral blood flow (rCBF) are not known. We therefore investigated changes in rCBF in a 5-day dry immersion (DI) model. Moreover, we tested thigh cuffs as a countermeasure to prevent potential microgravity-induced modifications in rCBF. Around 18 healthy male participants underwent 5-day DI with or without a thigh cuffs countermeasure. They were randomly allocated to a control (n=9) or cuffs (n=9) group. rCBF was measured 4days before DI and at the end of the fifth day of DI (DI5), using single-photon emission computed tomography (SPECT) with radiopharmaceutical 99mTc-hexamethyl propylene amine oxime (99mTc-HMPAO). SPECT images were processed using statistical parametric mapping (SPM12) software. At DI5, we observed a significant decrease in rCBF in 32 cortical and subcortical regions, with greater hypoperfusion in basal ganglia (right putamen peak level: z=4.71, puncorr<0.001), bilateral occipital regions (left superior occipital peak level: z=4.51, puncorr<0.001), bilateral insula (right insula peak level: 4.10, puncorr<0.001), and bilateral inferior temporal (right inferior temporal peak level: 4.07, puncorr<0.001). No significant difference was found between the control and cuffs groups on change in rCBF after 5days of DI. After a 5-day DI, we found a decrease in rCBF in cortical and subcortical regions. However, thigh cuffs countermeasure failed to prevent hypoperfusion. To date, this is the first study measuring rCBF in DI. Further investigations are needed in order to better understand the underlying mechanisms in cerebral blood flow (CBF) changes after exposure to microgravity.

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Biomechanics and regulation of external respiration under conditions of five-day dry immersion

Cited by 2 publications

References 7 publications

Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

Dry Immersion as a Ground-Based Model of Microgravity Physiological Effects

Reduced Regional Cerebral Blood Flow Measured by 99mTc-Hexamethyl Propylene Amine Oxime Single-Photon Emission Computed Tomography in Microgravity Simulated by 5-Day Dry Immersion

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