Biomechanics of callus in the bone healing process, determined by specimen-specific finite element analysis

Suzuki, Takane; Matsuura, Yusuke; Yamazaki, Takahiro; Akasaka, Tomoyo; Ozone, Ei; Matsuyama, Yoshiyuki; Mukai, Michiaki; Ohara, Takeru; Wakita, Hiromasa; Taniguchi, S.; Ohtori, Seiji

doi:10.1016/j.bone.2019.115212

Cited by 19 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We suggest that this limitation could be overcome by predicting callus strength using computed tomography (CT) [ 43 ]. However, a direct application of this method is not trivial in the case of the proposed experiment.…”

Section: Discussionmentioning

confidence: 99%

Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?

Barcik

Epari

2021

Biomedicines

View full text Add to dashboard Cite

The impact of the local mechanical environment in the fracture gap on the bone healing process has been extensively investigated. Whilst it is widely accepted that mechanical stimulation is integral to callus formation and secondary bone healing, treatment strategies that aim to harness that potential are rare. In fact, the current clinical practice with an initially partial or non-weight-bearing approach appears to contradict the findings from animal experiments that early mechanical stimulation is critical. Therefore, we posed the question as to whether optimizing the mechanical environment over the course of healing can deliver a clinically significant reduction in fracture healing time. In reviewing the evidence from pre-clinical studies that investigate the influence of mechanics on bone healing, we formulate a hypothesis for the stimulation protocol which has the potential to shorten healing time. The protocol involves confining stimulation predominantly to the proliferative phase of healing and including adequate rest periods between applications of stimulation.

show abstract

Section: Discussionmentioning

confidence: 99%

Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?

Barcik

Epari

2021

Biomedicines

View full text Add to dashboard Cite

show abstract

“…According to the contact method described in the reference, the threaded screw area was used for binding to the bone ( He et al, 2022 ). According to the report of Suzuki et al (2020) , meshes that included a 1-cm margin surrounding the osteotomy surface were degraded with weakening of the mesh material and simulated a callus during the bone healing process .…”

Section: Fe Simulationmentioning

confidence: 99%

Mechanical upside of PAO mainstream fixations: co-simulation based on early postoperative gait characteristics of DDH patients

Yang

Liu

Lin³

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Purpose: To investigate the early postoperative gait characteristics of patients who underwent periacetabular osteotomy (PAO) and predict the biomechanical performance of two commonly used PAO fixation methods: iliac screw (IS) and transverse screw (TS).Methods: A total of 12 patients with unilateral developmental dysplasia of the hip (DDH) (mean age 27.81 ± 4.64 years, 42% male) that were scheduled to undergo PAO surgery were included in this study. Their preoperative CT images and pre- and postoperative gait data were used to create subject-specific musculoskeletal models and complete the inverse dynamics analysis (IDA). Two patients with typical gait characteristics were selected using clustering analysis, and their IDA data were incorporated into finite element (FE) models of IS and TS fixations. Failure simulation was performed by applying iterative steps with increasing gait load to predict yield load. Stress results and yield loads were calculated for each FE model at different phases of the gait cycle.Results: Postoperative gait showed improvement compared to preoperative gait but remained inferior to that of healthy individuals. Postoperative gait was characterized by a lower hip range of motion, lower peri-ilium muscle forces, particularly in the abductors, and a sharper initial peak and flatter second peak of hip joint reaction force (HRF). Finite element analysis (FEA) showed a trend of increasing stress during the second–fourth phases of the gait cycle, with lower stress levels in other phases. At high-stress gait phases, the mean stress of maximum p¯100 differed significantly between IS and TS (p < 0.05) and between coupled and uncoupled muscle forces (p < 0.05). Failure analysis predicted a slightly larger yield load for TS configurations (6.21*BW) than that for IS (6.16*BW), but both were well above the gait load. Coupled and uncoupled groups showed similar results, but uncoupled groups had lower yield loads (5.9*BW).Conclusion: PAO early postoperative gait shows a normalized trend, but abnormalities persist. IS and TS are both capable of resisting mechanical strain failure, with no significant mechanical advantage found for transverse screw fixation during PAO early postoperative gait. Additionally, it is important to note that the TS may have a higher risk of cyclic fatigue failure due to the localized greater stress concentration. Furthermore, the most medial screw is crucial for pelvic stability.

show abstract

“…However, this method can only be employed in vitro. On the other hand, by using the density-modulus equation derived from experiments, finite element analysis could predict bone strength in vivo [ 62 ]. Dailey et al [ 63 ] scanned a group of patients with tibial shaft fracture by three-dimensional CT reconstruction.…”

Section: Introductionmentioning

confidence: 99%

The progress in quantitative evaluation of callus during distraction osteogenesis

Liu

Guo

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

The manual monitoring of callus with digital radiography (X-ray) is the primary bone healing evaluation, assessing the number of bridged callus formations. However, this method is subjective and nonquantitative. Recently, several quantitative monitoring methods, which could assess the recovery of the structure and biomechanical properties of the callus at different stages and the process of bone healing, have been extensively investigated. These methods could reflect the bone mineral content (BMC), bone mineral density (BMD), stiffness, callus and bone metabolism at the site of bone lengthening. In this review, we comprehensively summarized the latest techniques for evaluating bone healing during distraction osteogenesis (DO): 1) digital radiography; 2) dual-energy X-ray scanning; 3) ultrasound; 4) quantitative computed tomography; 5) biomechanical evaluation; and 6) biochemical markers. This evidence will provide novel and significant information for evaluating bone healing during DO in the future.

show abstract

Biomechanics of callus in the bone healing process, determined by specimen-specific finite element analysis

Cited by 19 publications

References 30 publications

Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?

Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?

Mechanical upside of PAO mainstream fixations: co-simulation based on early postoperative gait characteristics of DDH patients

The progress in quantitative evaluation of callus during distraction osteogenesis

Contact Info

Product

Resources

About