Biomechanics of Ligaments: From Molecular Biology to Joint Function

King, Albert I.; Yang, King H.; Zhang, Liying; Hardy, Warren N.

doi:10.1007/978-1-4419-8967-3_9

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…On the one hand, the findings reported by Bayly and colleagues, 42,43 King and colleagues, 39 Ross and colleagues, 19 Vivano and colleagues, 41 and Zhang and colleagues 40 seem to support a primary injury model. On the other hand, the results described by Adams and colleagues, 21 Anderson and colleagues, 7 and Natale and colleagues 22 appear to corroborate a secondary injury model.…”

Section: Discussionmentioning

confidence: 93%

The Role of Thalamic Damage in Mild Traumatic Brain Injury

Grossman

Inglese

2016

Journal of Neurotrauma

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There is growing alarm in the United States about an epidemiologically large occurrence of mild traumatic brain injury with serious long lasting consequences. Although conventional imaging has been unable to identify damage capable of explaining its organic origin or discerning patients at risk of developing long-term or permanently disabling neurological impairment, most disease models assume that diffuse axonal injury in white matter must be present but is difficult to resolve. The few histopathological investigations conducted, however, show only limited evidence of such damage, which cannot account for the stereotypical globalized nature of symptoms generally reported in patients. This review examines recent proposals that in addition to white matter, the thalamus may be another important further site of injury. Although its possible role still remains largely under-investigated, evidence from experimental human and animal models, as well as simulational and analytical representations of mild head injury and other related conditions, suggest that this strategically vital region of the brain, which has reciprocal projections to the entire cerebral cortex, could feasibly play an important role in understanding pathology and predicting outcome.

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Section: Discussionmentioning

confidence: 93%

The Role of Thalamic Damage in Mild Traumatic Brain Injury

Grossman

Inglese

2016

Journal of Neurotrauma

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“…21,22 Simulations from finite element head modeling have revealed the thalamus is a region of high shear stress during neurotrauma. 23,24 Furthermore, secondary neuroinflammatory and degenerative processes—which have been demonstrated to persist for many years following neurotrauma—also contribute to thalamic damage following TBI. 16,25–27 Structural magnetic resonance imaging (MRI) methods have been used to examine both global and more nuanced topographic, or regional, alterations of the thalamus post-TBI.…”

Section: Introductionmentioning

confidence: 99%

Fatigue Is Associated With Global and Regional Thalamic Morphometry in Veterans With a History of Mild Traumatic Brain Injury

Clark¹,

Sorg²,

Holiday³

et al. 2018

Journal of Head Trauma Rehabilitation

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“…Increasing evidence supports a thalamic hypothesis as the central mechanism for global cognitive impairment from mTBI/ PCS [9]. King et al [10] examined brain displacement and deformation using various concussive forces on cadavers. Their findings indicated a primary injury to the thalamus.…”

Section: Introductionmentioning

confidence: 99%

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2019

OPROJ

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Significance: Concussions or mild traumatic brain injuries (mTBIs) are the most common form of traumatic brain injury. There is lack of reliable, diagnostic tools in healthcare for the treatment of mTBI. A Visual Evoked Potential (VEP) approach will enhance practitioners in diagnosing and treating mTBI. Purpose:The aim of this study was to evaluate changes in brain function associated mTBI/post-concussion syndrome (PCS) using Visual Evoked Potential (VEP). We examined the effects of mTBI on early visual processing to determine if the signs and symptoms of mTBI reflected the failure of retinal signal latency based on the paradigm that low spatial frequency (LSF) are processed faster than high spatial frequency (HSF) when measured at the primary visual cortex. Methods:The VEP of participants were measured by biasing the magnocellular pathways using a low Michelson contrast, temporally modulated phase reversing checkerboard stimulus pattern, and successive spatial frequency (SF) from LSF to increasing HSF. The VEP values of participants from the control group where compared with VEP values obtained from the mTBI/ PCS group. Participants from the mTBI/PCS group underwent a 6 week-7 month treatment. Results:The mTBI/PCS group failed to process the LSF faster than the increasing HSF, which resulted in loss of top-down information that leads to meaningful perception. Conclusions:The mTBI/PCS subjects resolved their VEP deficits and returned to the proper temporal organization of latency, compared with the results from the control group.

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Biomechanics of Ligaments: From Molecular Biology to Joint Function

Cited by 5 publications

References 20 publications

The Role of Thalamic Damage in Mild Traumatic Brain Injury

The Role of Thalamic Damage in Mild Traumatic Brain Injury

Fatigue Is Associated With Global and Regional Thalamic Morphometry in Veterans With a History of Mild Traumatic Brain Injury

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