Biomedical Applicable Cellulose Fabric Modified with Zirconium‐Based Metal‐Organic Frameworks (Zr‐MOFs)

Abstract

Zirconium-based metal-organic frameworks (Zr-MOFs) have been synthesized onto diverse substrates however thermal and acidic conditions of synthesis processing impair or carbonize the polysaccharide based substrate. Also, MOF-coated polysaccharides usually show poor mechanical properties and instability in aqueous conditions unsuitable for biomedical applications. There is no report on the synthesis of MOFs on cellulosic substrate to preserve intactness. Here, an optimized Zr-MOFs synthesis method on cotton fabric is introduced to prepare a biomedically applicable Zr-MOFs modified cellulosic fabric. The resultant fabric demonstrates an absolute wash durability with enhanced hydrophilicity and better mechanical properties with higher Zr-MOFs content. The treated fabric shows 787% and 2105% improvement in absorption capacity for Salvia officinalis (SO) and Calendula officinalis (CO) extracts and the release kinetic model of diffusion mechanism. Cotton-MOF-SO and Cotton-MOF-CO confirm antibacterial activity of 99.2% and 37.4% against Escherichia coli and 19.9% and 35.3% against Staphylococcus aureus. Finally, the cotton-MOF-CO can be considered as a biocompatible material however cotton-MOF-SO exhibits high toxicity signifying its potentiality for inducing death to cancer cells.

Reactive Chlorine Capture by Dichlorination of Alkene Linkers in Metal–Organic Frameworks

“…Both of these materials irreversibly capture Cl 2 significantly better than unfunctionalized UiO-66 and a representative mesoporous carbon. Considering that Zr-MOFs have been widely appended to fabrics already, , both Zr-fum and Zr-stilbene could function as protective Cl 2 sponges in next-generation PPE. Beyond their application for Cl 2 capture, the linker dichlorination reactions reported herein enable the installation of sp 3 -hydridized carbons within MOFs, which is difficult to achieve but can improve the MOF’s mechanical properties …”

Reactive Chlorine Capture by Dichlorination of Alkene Linkers in Metal–Organic Frameworks

“…Both of these materials irreversibly capture Cl2 significantly better than unfunctionalized UiO-66 and a representative mesoporous carbon. Considering that Zr-MOFs have been widely appended to fabrics already, 41,42 both Zr-fum and Zr-stilbene could function as protective Cl2 sponges in next-generation PPE. Beyond their application for Cl2 capture, the linker dichlorination reactions reported herein enable the installation of sp 3 hydridized carbons within MOFs, which is difficult to achieve but can improve MOF mechanical properties.…”

Metal-Organic Framework (MOF)—A Universal Material for Biomedicine

“…For biomedical purposes, MOFs of multivalent metals such as zirconium (IV) [40], iron (III) [41,42], zinc (II) [43], and copper (II) [44] are more applicable. The ligands used in MOF synthesis usually have several carboxylic or amine functional groups that depart either from the alkyl chain or from a ring structure such as benzene or imidazole [45].…”