Biomedical applications of biodegradable polycaprolactone-functionalized magnetic iron oxides nanoparticles and their polymer nanocomposites

Obisesan, Oluwafemi Samuel; Ajiboye, Timothy O.; Mhlanga, Sabelo D.; Mufhandu, Hazel Tumelo

doi:10.1016/j.colsurfb.2023.113342

Cited by 22 publications

(4 citation statements)

References 121 publications

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“…This reduction in chain length results in the formation of acidic autocatalysis products; hydroxyl and carboxyl groups. If these carboxyl groups are not removed, the PCL degradation is accelerated due to the polymer becomes acidic causing autocatalysis hydrolysis degradation of the polymer [101,105,107].…”

Section: Discussionmentioning

confidence: 99%

Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

ElBakry,

Ammar,

Moussa

2024

Biomed. Mater.

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This study was designed to deposit nanodiamonds on 3D-printed PCL scaffolds and evaluate their effect on the surface topography, hydrophilicity, degradation, and in-vitro cell adhesion compared to untreated PCL scaffolds. The PCL scaffold specimens were 3D-printed by fused deposition molding (FDM) technique with specific porosity parameters. The 3D-printed specimens' surfaces were modified by nanodiamonds deposition followed by oxygen plasma post-treatment using a plasma focus (PF) device and a non-thermal atmospheric plasma jet (NTAPJ), respectively. Specimens were evaluated through morphological characterization by field emission scanning electron microscope (FESEM), microstructure characterization by Raman spectroscopy, chemical characterization by Fourier transform infrared (FTIR) spectroscopy, hydrophilicity degree by contact angle and water uptake measurements, and in-vitro degradation measurements (n=6). In addition, in-vitro bone marrow mesenchymal stem cells (BMSCs) adhesion was evaluated quantitatively by Confocal microscopy and qualitatively by FESEM at different time intervals after cell seeding (n=6). The statistical significance level was set at p ≤0.05. The FESEM micrographs, the Raman, and FTIR spectra confirmed the successful surface deposition of nanodiamonds on scaffold specimens. The nanodiamonds treated specimens showed nano-scale features distributed homogeneously across the surface compared to the untreated ones. Also, the nanodiamonds treated specimens revealed a statistically significant smaller contact angle (17.45 ±1.34 degrees), higher water uptake percentage after 24 h immersion in phosphate buffer saline (PBS) (21.56% ±1.73), and higher degradation rate after six months of immersion in PBS (43.92% ±0.77). Moreover, enhanced cell adhesion at all different time intervals was observed in nanodiamonds treated specimens with higher nuclei area fraction percentage (69.87% ±3.97) compared to the untreated specimens (11.46% ±1.34). Surface deposition of nanodiamonds with oxygen-containing functional groups on 3D-printed PCL scaffolds increased their hydrophilicity and degradation rate with significant enhancement of the in-vitro cell adhesion compared to untreated PCL scaffolds.

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Section: Discussionmentioning

confidence: 99%

Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

ElBakry,

Ammar,

Moussa

2024

Biomed. Mater.

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“…These NCs combine the characteristics of the nanofillers and polymers, resulting in macroscopic features (strength, hardness, and toughness) in the NCs. 60 Accordingly, they have been utilized in various applications such as adhesives, anticorrosive coatings, drilling fluids, electronic devices, and electric circuits. 32,61–63…”

Section: Polymer-based Nanocompositesmentioning

confidence: 99%

Carbohydrate polymer-supported metal and metal oxide nanoparticles for constructing electrochemical sensors

Zahran

2024

Mater. Adv.

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“…[7,8] Such as polylactic acid glycolic acid (PLGA) and polycaprolactone (PCL), some of which have been approved by FDA for clinical use, with the advantages of degradability and low toxicity, but most of the degradation products have no therapeutic effect. [9][10][11] In addition, multiple administration increases drug toxicity, and single drug therapy can not meet the functional recovery SCI. [12] At present, polyprodrug delivery system has attracted wide attention.…”

Section: Introductionmentioning

confidence: 99%

Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury

Chen,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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Oxidative stress (OS) is one of the crucial molecular events of secondary spinal cord injury (SCI). Basic fibroblast growth factor (bFGF) is a multipotent cell growth factor with an anti‐oxidant effect. However, bFGF has a short half‐life in vivo, which limits its therapeutic application. Biodegradable polymers with excellent biocompatibility have been recently applied in SCI. The negative aspect is that polymers cannot provide a significant therapeutic effect. Betulinic acid (BA), a natural anti‐inflammatory compound, has been polymerized into poly (betulinic acid) (PBA) to serve as a drug carrier for bFGF. This study explores the therapeutic effects and underlying molecular mechanisms of PBA nanoparticles (NPs) loaded with bFGF (PBA‐bFGF NPs) in SCI. Results show that PBA‐bFGF NPs produce remarkable biocompatibility in vivo and in vitro. The results also demonstrate that local delivery of PBA‐bFGF NPs enhances motor function recovery, inhibits OS, mitigates neuroinflammation and alleviates neuronal apoptosis following SCI. Furthermore, the results indicate that local delivery of PBA‐bFGF NPs activates the Nuclear Factor erythroid 2‐Related Factor 2 (Nrf‐2) signaling pathway following SCI. In summary, results suggest that local delivery of PBA‐bFGF NPs delivers potential therapeutic advantages in the treatment and management of SCI.This article is protected by copyright. All rights reserved

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Biomedical applications of biodegradable polycaprolactone-functionalized magnetic iron oxides nanoparticles and their polymer nanocomposites

Cited by 22 publications

References 121 publications

Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

Effect of nanodiamonds surface deposition on hydrophilicity, bulk degradation and in-vitro cell adhesion of 3D-printed polycaprolactone scaffolds for bone tissue engineering

Carbohydrate polymer-supported metal and metal oxide nanoparticles for constructing electrochemical sensors

Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury

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