Biomedical applications of electrospun nanofibers in the management of diabetic wounds

Pamu, Divya; Tallapaneni, Vyshnavi; Karri, Veera Venkata Satyanarayana Reddy; Singh, Sachin Kumar

doi:10.1007/s13346-021-00941-6

Cited by 11 publications

(15 citation statements)

References 58 publications

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“…This is ideally accomplished by a 3D network of biocompatible and biodegradable nanofibers with high porosity that allows cells to adhere, proliferate and differentiate [75][76][77]. Sufficient mechanical strength is another prerequisite of such a scaffold [17]. A so-called asymmetric membrane would in addition contain an outer layer with rather low porosity, that is, small pores and hydrophobic properties [78].…”

Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

“…This also applies to biodegradability. Polylactic acid (PLA), poly-D,L-lactide-coglycolic acid (PLGA), polyvinyl alcohol (PVA), or polycaprolactone (PCL) are widely used synthetic polymers [17,20]. To utilize the advantages of both materials and to overcome the limitations of each, bioengineering evaluates mixtures of natural and synthetic materials as nanofibrous scaffolds [91].…”

Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

“…Pamu et al [17] have recently performed a systematic review and nicely summarize the results of applying one material for scaffold formation. PLA [99], collagen [100], a combination of chitosan, PVA, and zinc oxide [101], a blend of curdlan and PVA [102] were studied among others in the treatment of chronic wounds in diabetic patients.…”

Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

“…Of special interest for skin replacement are asymmetric membranes that consist of two layers that resemble the functions of the epidermis and dermis. Such electrospun scaffolds enhance porosity, the absorption of moisture, exchange of oxygen, and antimicrobial properties as well as outer protection and barrier function [17][18][19][20][21][22][23]. Another innovative way to produce such a bilayered skin scaffold is constituted by high hydrostatic pressure (HHP).…”

Section: Introductionmentioning

confidence: 99%

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Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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Skin regeneration is a quite complex process. Epidermal differentiation alone takes about 30 days and is highly regulated. Wounds, especially chronic wounds, affect 2% to 3% of the elderly population and comprise a heterogeneous group of diseases. The prevailing reasons to develop skin wounds include venous and/or arterial circulatory disorders, diabetes, or constant pressure to the skin (decubitus). The hallmarks of modern wound treatment include debridement of dead tissue, disinfection, wound dressings that keep the wound moist but still allow air exchange, and compression bandages. Despite all these efforts there is still a huge treatment resistance and wounds will not heal. This calls for new and more efficient treatment options in combination with novel biocompatible skin scaffolds. Cold atmospheric pressure plasma (CAP) is such an innovative addition to the treatment armamentarium. In one CAP application, antimicrobial effects, wound acidification, enhanced microcirculations and cell stimulation can be achieved. It is evident that CAP treatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.

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Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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show abstract

“…[13] Fibrous materials with high drug-loading rates and good stability can ideally meet the requirements of reduced inflammation, faster healing, tissue regeneration, and present promising options for diabetic wounds. [14] Electrospinning is a viable and versatile technique for producing fibrous substrates from both natural and synthetic polymers for wound dressing. [14,15] The porous structure and high specific surface area of electrospun fibers create opportunities for liquid and gas exchange to maintain the favorable physiological environment of the wound while also providing a robust physical barrier to particulates and bacteria.…”

mentioning

confidence: 99%

A Shape‐Programmable Hierarchical Fibrous Membrane Composite System to Promote Wound Healing in Diabetic Patients

Jiang

et al. 2022

Small

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Chronic wound infection is one of the critical complications of diabetes and is difficult to cure. Although great efforts have been made, the development of special dressings that serve as therapeutic strategies to effectively promote wound healing in diabetic individuals remains a major challenge. In this study, a shape‐programmable hierarchical fibrous membrane composite system is developed for synergistic modulation of the inflammatory microenvironment to treat chronically infected wounds. The system comprises a functional layer and a shape‐programmable backing layer. A temperature‐responsive shape‐memory mechanism achieves biaxial mechanically active contractions of diabetic wounds in a programmable manner. To summarize, the membrane system combines antimicrobial activity, controlled drug release according to the need of wound healing, mechanical modulation with shape‐programmable, robust adhesion, and on‐demand debonding to biological tissue to rationally guide chronic wound management. A synergistic combination of antibacterial fiber network and released drugs shows broad‐spectrum antibacterial activity. In vitro and in vivo evaluations indicate the dressing efficiency in promoting and supporting wound healing. The insights from this study demonstrate the effectiveness of a hierarchical composite membrane system with shape‐programmability as a potential treatment in the care of diabetic wounds.

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Diabetes immunity-modulated multifunctional hydrogel with cascade enzyme catalytic activity for bacterial wound treatment

Deng

Zhang²,

Li³

et al. 2022

Biomaterials

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Biomedical applications of electrospun nanofibers in the management of diabetic wounds

Cited by 11 publications

References 58 publications

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

A Shape‐Programmable Hierarchical Fibrous Membrane Composite System to Promote Wound Healing in Diabetic Patients

Diabetes immunity-modulated multifunctional hydrogel with cascade enzyme catalytic activity for bacterial wound treatment

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