Biomedical applications of environmental friendly poly-hydroxyalkanoates

Ansari, Sabbir; Sami, Neha; Yasin, Durdana; Ahmad, Naeem; Fatma, Tasneem

doi:10.1016/j.ijbiomac.2021.04.171

Cited by 54 publications

(40 citation statements)

References 201 publications

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“…PHA production is a purely biological intracellular synthesis performed by bacterial cells grown on various carbon sources. PHAs are represented by polymers with different chemical structures and considerably diverse properties: molecular-weight and temperature characteristics, degree of crystallinity, and biodegradation behavior and rates [6,[16][17][18][19][20][21]. PHAs may be potentially produced from substrates that can be reduced to different degrees and that vary in energy content and cost such as individual compounds and complex substrates, including industrial wastes [22].…”

Section: Introductionmentioning

confidence: 99%

Properties of Degradable Polyhydroxyalkanoates (PHAs) Synthesized by a New Strain, Cupriavidus necator IBP/SFU-1, from Various Carbon Sources

et al. 2021

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The bacterial strain isolated from soil was identified as Cupriavidus necator IBP/SFU-1 and investigated as a PHA producer. The strain was found to be able to grow and synthesize PHAs under autotrophic conditions and showed a broad organotrophic potential towards different carbon sources: sugars, glycerol, fatty acids, and plant oils. The highest cell concentrations (7–8 g/L) and PHA contents were produced from oleic acid (78%), fructose, glucose, and palm oil (over 80%). The type of the carbon source influenced the PHA chemical composition and properties: when grown on oleic acid, the strain synthesized the P(3HB-co-3HV) copolymer; on plant oils, the P(3HB-co-3HV-co-3HHx) terpolymer, and on the other substrates, the P(3HB) homopolymer. The type of the carbon source influenced molecular-weight properties of PHAs: P(3HB) synthesized under autotrophic growth conditions, from CO2, had the highest number-average (290 ± 15 kDa) and weight-average (850 ± 25 kDa) molecular weights and the lowest polydispersity (2.9 ± 0.2); polymers synthesized from organic carbon sources showed increased polydispersity and reduced molecular weight. The carbon source was not found to affect the degree of crystallinity and thermal properties of the PHAs. The type of the carbon source determined not only PHA composition and molecular weight but also surface microstructure and porosity of the polymer films. The new strain can be recommended as a promising P(3HB) producer from palm oil, oleic acid, and sugars (fructose and glucose) and as a producer of P(3HB-co-3HV) from oleic acid and P(3HB-co-3HV-co-3HHx) from palm oil.

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Section: Introductionmentioning

confidence: 99%

Properties of Degradable Polyhydroxyalkanoates (PHAs) Synthesized by a New Strain, Cupriavidus necator IBP/SFU-1, from Various Carbon Sources

et al. 2021

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“…PHAs are materials synthesized by bacteria as energy sources in bad growth environments [55]. They show properties including biodegradability, biocompatibility, and good mechanical capacity with the potential to induce vascularization, making them great candidates for BTE [56].…”

Section: Polyhydroxyalkanoates (Pha)mentioning

confidence: 99%

“…They show properties including biodegradability, biocompatibility, and good mechanical capacity with the potential to induce vascularization, making them great candidates for BTE [56]. Additionally, PHAs have various forms in hard tissue and soft tissue; thus, both flexible artificial blood vessels and firm bone tissues can be produced by PHAs [55]. Furthermore, PHA is easy to blend with other materials and reaches a compressive strength which is the same as true human bones (62 MPa) [57].…”

Section: Polyhydroxyalkanoates (Pha)mentioning

confidence: 99%

Current Biomaterial-Based Bone Tissue Engineering and Translational Medicine

et al. 2021

IJMS

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Bone defects cause significant socio-economic costs worldwide, while the clinical “gold standard” of bone repair, the autologous bone graft, has limitations including limited graft supply, secondary injury, chronic pain and infection. Therefore, to reduce surgical complexity and speed up bone healing, innovative therapies are needed. Bone tissue engineering (BTE), a new cross-disciplinary science arisen in the 21st century, creates artificial environments specially constructed to facilitate bone regeneration and growth. By combining stem cells, scaffolds and growth factors, BTE fabricates biological substitutes to restore the functions of injured bone. Although BTE has made many valuable achievements, there remain some unsolved challenges. In this review, the latest research and application of stem cells, scaffolds, and growth factors in BTE are summarized with the aim of providing references for the clinical application of BTE.

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“…They can be formulated and refined for use in agriculture, packaging, molding products, paper coatings, adhesives, films, and performance additives [156]. PHAs are a promising implant material as they are biodegradable, biocompatible, nontoxic, and tissue friendly with blood, bone, cartilage, and human cell lines as well as mammals [157]. Various therapeutics have been developed from PHAs such as sutures, articular cartilage repair devices and patches, cardiovascular patches, orthopedic pins, adhesion barriers, stents, guided tissue repair/regeneration devices, nerve guides, wound dressings, tendon repair devices, 3D custom-made bone marrow scaffolds, etc.…”

Section: Recent Trends In Pha Applicationsmentioning

confidence: 99%

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

et al. 2021

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Polyhydroxyalkanoates (PHAs) are storage granules found in bacteria that are essentially hydroxy fatty acid polyesters. PHA molecules appear in variety of structures, and amongst all types of PHAs, polyhydroxybutyrate (PHB) is used in versatile fields as it is a biodegradable, biocompatible, and ecologically safe thermoplastic. The unique physicochemical characteristics of these PHAs have made them applicable in nanotechnology, tissue engineering, and other biomedical applications. In this review, the optimization, extraction, and characterization of PHAs are described. Their production and application in nanotechnology are also portrayed in this review, and the precise and various production methods of PHA-based nanoparticles, such as emulsion solvent diffusion, nanoprecipitation, and dialysis are discussed. The characterization techniques such as UV-Vis, FTIR, SEM, Zeta Potential, and XRD are also elaborated.

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Biomedical applications of environmental friendly poly-hydroxyalkanoates

Cited by 54 publications

References 201 publications

Properties of Degradable Polyhydroxyalkanoates (PHAs) Synthesized by a New Strain, Cupriavidus necator IBP/SFU-1, from Various Carbon Sources

Properties of Degradable Polyhydroxyalkanoates (PHAs) Synthesized by a New Strain, Cupriavidus necator IBP/SFU-1, from Various Carbon Sources

Current Biomaterial-Based Bone Tissue Engineering and Translational Medicine

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

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