Biomedical applications of ferulic acid encapsulated electrospun nanofibers

Abstract

Ferulic acid is a ubiquitous phytochemical that holds enormous therapeutic potential but has not gained much consideration in biomedical sector due to its less bioavailability, poor aqueous solubility and physiochemical instability. In present investigation, the shortcomings associated with agro-waste derived ferulic acid were addressed by encapsulating it in electrospun nanofibrous matrix of poly (d,l-lactide-co-glycolide)/polyethylene oxide. Fluorescent microscopic analysis revealed that ferulic acid predominantly resides in the core of PLGA/PEO nanofibers. The average diameters of the PLGA/PEO and ferulic acid encapsulated PLGA/PEO nanofibers were recorded as 125 ± 65.5 nm and 150 ± 79.0 nm, respectively. The physiochemical properties of fabricated nanofibers are elucidated by IR, DSC and NMR studies. Free radical scavenging activity of fabricated nanofibers were estimated using di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH) assay. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay confirmed the cytotoxicity of ferulic acid encapsulated nanofibers against hepatocellular carcinoma (HepG2) cells. These ferulic acid encapsulated nanofibers could be potentially explored for therapeutic usage in biomedical sector.

Hydroxycinnamic Acids and Their Derivatives: Cosmeceutical Significance, Challenges and Future Perspectives, a Review

“…Complete release of ferulic acid was achieved after a few days, and the antioxidant activity was also found to be higher. Furthermore, Vashisth et al [ 140 ] isolated and characterized ferulic acid from the Parthenium hysterophorus L. plant, further nanoencapsulated by electrospinning. Poly lactic-co-glycolic acid (PLGA) and polyethylene oxide (PEO) were employed as encapsulating materials at a PLGA:PEO ratio of 1:1 using dichloromethane/dimethylformamide (4:1, v / v ) as the solubilizing medium.…”

Active Food Packaging Coatings Based on Hybrid Electrospun Gliadin Nanofibers Containing Ferulic Acid/Hydroxypropyl-Beta-Cyclodextrin Inclusion Complexes

“…Ferulic acid (FA, 4-hydroxy-3-methoxy cinnamic acid), a phenolic compound classified in the group of the hydroxycinnamic acids, is present in commelinid plants such as rice, wheat, oats, and some vegetables, fruits, and nuts [ 1 ]. FA exhibits a wide range of biological and biomedical effects including antioxidant [ 2 ], anti-inflammatory [ 3 ], anti-diabetic [ 4 ], hepatoprotective [ 5 ] and anti-carcinogenic [ 6 ], among others. In addition, FA has been approved as a food additive, hindering the peroxidation of lipids due to its scavenging capability of superoxide anion radicals [ 7 , 8 ].…”

Fabrication of nanofiber coated with l-arginine via electrospinning technique: a novel nanomatrix to counter oxidative stress under crosstalk of co-cultured fibroblasts and satellite cells

“…Treatment with ferulic acid encapsulated nanofibers reduced the cytotoxicity against hepatocellular carcinoma (HepG2) (Vashisth et al 2015). Moreover, niclosamide-AgNPs composite nanofibers showed more orange-red color fluorescence compared to control MCF-7 and A549 cells (Vashisth et al 2015). However, for the first time, we found that PU nanofibrous scaffold conjugated with L-arginine could reduce the orange-red color and increase the green color appearance in co-cultured satellite cells than monoculture under oxidative stress condition.…”

“…In our study, PU-L-Arginine nanofibrous scaffold was suitable for growth of H 2 O 2 induced co-cultured satellite cells than monoculture. Treatment with ferulic acid encapsulated nanofibers reduced the cytotoxicity against hepatocellular carcinoma (HepG2) (Vashisth et al 2015). Moreover, niclosamide-AgNPs composite nanofibers showed more orange-red color fluorescence compared to control MCF-7 and A549 cells (Vashisth et al 2015).…”