Biomedical applications of imidazolium cation‐modified iron oxide nanoparticles

Naka, Kensuke; Narita, Asako; Tanaka, Hiroaki; Chujo, Yoshiki; Morita, Masahito; Inubushi, Toshiro; Nishimura, Ikumi; Hiruta, J.; Shibayama, Hiroshi; Koga, Masaaki; Ishibashi, Seitaro; Seki, Junzo; Kizaka‐Kondoh, Shinae; Hiraoka, Masahiro

doi:10.1002/pat.1218

Cited by 49 publications

(41 citation statements)

References 32 publications

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“…The magnetization curve of the MNPs (black) and M@PEI nanoparticles (blue) were measured at room temperature, and the magnetization was normalized by the mass of all of the particles, as shown in Figure . The MNPs had a high magnetic value of 52.4 emu/g . After decoration by PEI, the magnetic value was 31.2 emu/g before it decreased; this indicated that the increase in the shell thickness caused a reduction in the magnetic value to a certain extent .…”

Section: Resultsmentioning

confidence: 94%

Decorated‐magnetic‐nanoparticle‐supported bromine as a recyclable catalyst for the oxidation of sulfides

Tao

et al. 2017

J of Applied Polymer Sci

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Herein, we present a strategy for supporting bromine as a catalyst for the oxidation of sulfides. In this strategy, branched poly(ethylene imine) was first decorated by magnetic oxide and then used to support liquid bromine to obtain solid polymeric bromine (M@PEI@Br) nanoparticles. Compared with free bromine, the stability of the M@PEI@Br nanoparticles improved obviously. The oxidation of thioanisole to methyl phenyl sulfoxide was chosen as a reaction model to evaluate the catalytic activity of the M@PEI@Br nanoparticles. All of the obtained results verify that the M@PEI@Br nanoparticles exhibited excellent catalytic efficiency and could accelerate the oxidation process under solvent-free conditions at room temperature; this highlighted the potential of decorated polymers to support active and unstable small-molecule organic catalysts.

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Section: Resultsmentioning

confidence: 94%

Decorated‐magnetic‐nanoparticle‐supported bromine as a recyclable catalyst for the oxidation of sulfides

Tao

et al. 2017

J of Applied Polymer Sci

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“…To form a water-dispersive aggregate of gold nanoparticles, the carboxylate anion 1, which has a photo-cleavable functional group, was mixed into the imidazolium-presenting gold nanoparticles by employing ionic liquid structures 33,34 via anion exchange with chloride anions. Under aqueous conditions, the gold nanoparticles should be aggregated because of the enhanced hydrophobicity due to 1.…”

Section: Resultsmentioning

confidence: 99%

Control of interparticle spacing in stable aggregates of gold nanoparticles by light irradiation

Tanaka

Naka

Miyoshi

et al. 2015

Polym J

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This study describes the modulation of interparticle distances in aggregates of gold nanoparticles by light irradiation. Stable aggregates of a series of imidazolium-presenting gold nanoparticles were obtained via a photo-responsive mono-carboxylate linker. In the first step, the mono-carboxylate linker attracted the gold nanoparticles to form water-dispersive aggregates of gold nanoparticles with hydrophobic surface properties. By irradiating the aggregates with ultraviolet, the photo-responsive linker was transformed, leading to the generation of another carboxyl group. As a result, the gold nanoparticles were tightly bound via the dicarboxylate linkers. These changes decreased the interparticle distances in the aggregates, as verified by microscopic observations, and can induce significant changes in their optical characteristics. To the best of our knowledge, this is the first example of a light-driven manipulation system for the distribution of nanoparticles in an aggregate. INTRODUCTIONThe physical properties of metal nanoparticles strongly depend on their assembled states. It is known that an assembly of gold nanoparticles has different light-absorption properties to that of single particles. 1,2 Based on this phenomenon, a wide variety of biomedical applications has been accomplished. 3,4 In addition, by manipulating the hybridization process involved in anchoring DNA to the surface of particles, cluster formation and morphology can be precisely controlled. 5-7 These manipulation methods for the nanoparticle assembly are versatile and can be used to construct biosensors with good response to stimuli. 8,9 Furthermore, additional functions have been derived from the specific distribution of nanoparticles in an assembly. For instance, a class of unique optical functional materials involving metamaterials has been manufactured with a well-ordered assembly of gold nanoparticles. 10-13 Therefore, precisely controlling the morphology and relative positions of nanoparticles in an assembly is critically important to obtain superior or unexpected functions. [14][15][16][17][18][19][20] Structural manipulation with light has various advantages. A rapid, time-sensitive, and site-sensitive response can be achieved without additives. In previous reports, the photoisomerizations of azobenzene 21-26 and stilbene derivatives 27-29 tethered to the surface of nanoparticles have been investigated. Based on the structural changes triggered by the light irradiation, the dispersion states were controlled. The aggregation/dispersion of gold nanoparticles can also be modulated reversibly by the photo-triggered dimerization of thymine and the splitting of the thymine dimer. 30 Although the formation of aggregates can be controlled with various methods, as mentioned here, modulating the morphology of the aggregates is less well established.

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“…surface modification of metal nanoparticles involving. [8] Next, key materials have been required to extend the validity of SPIO-based probes for imaging and sensing.…”

Section: Please Scroll Down For Articlementioning

confidence: 99%

“…[8] By the surface exchange to tributylhexadecylphosphonium bromide under sonication with the oleic acidcoated SPIO 1, the desired product was prepared. NP2 was also obtained via the surface exchange with the silica-coated SPIO 2.…”

Section: Composite Interfaces 561mentioning

confidence: 99%

“…[8] After the addition of 5 mL of the acetone solution containing oleic acid (0.2 mL, 0.63 mmol) with mechanical stirring at 1000 rpm, 15 mL of aqueous ammonium hydroxide (28%) was added to the solution all at once. Oleic acid (0.2 mL) was continuously added to the solution in four additions every 5 min with stirring at 1000 rpm at 60°C.…”

Section: Preparation Of Np1mentioning

confidence: 99%

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Regulation of dispersion/aggregation of phosphonium-presenting iron oxide nanoparticles by anion exchange

Tanaka

Narita

Suzuki

et al. 2012

Composite Interfaces

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We describe synthesis of three kinds of phosphonium-presenting superparamagnetic iron oxides (SPIOs) with different anchoring motifs and their stimuli responsiveness to anion exchange. The series of the modified SPIOs with or without direct bonding to phosphonium bromides were prepared. With these modified SPIOs, an influence of the anion exchange on the dispersion states was investigated. Accordingly, the direct anchoring of phosphonium cation to the surface could contribute to improving sensitivity of the aggregation formation when the hydrophobicity of the surface was enhanced. Finally, it was found that the modified SPIOs with directlyconnected phosphonium cation immediately formed the assembly in the presence of citrate anion.

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Biomedical applications of imidazolium cation‐modified iron oxide nanoparticles

Cited by 49 publications

References 32 publications

Decorated‐magnetic‐nanoparticle‐supported bromine as a recyclable catalyst for the oxidation of sulfides

Decorated‐magnetic‐nanoparticle‐supported bromine as a recyclable catalyst for the oxidation of sulfides

Control of interparticle spacing in stable aggregates of gold nanoparticles by light irradiation

Regulation of dispersion/aggregation of phosphonium-presenting iron oxide nanoparticles by anion exchange

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