Biomedical applications of iron sulfide-based nanozymes

Abstract

Nanozymes have attracted great interest owing to their marvelous advantages, such as high stability, facile preparation, and high tunability. In particular, iron sulfide-based nanozymes (termed as ISNs), as one of the most researched nanomaterials with versatile enzyme-mimicking properties, have proved their potential in biomedical applications. In this review, we briefly summarize the classification, catalytic mechanisms of ISNs and then principally introduce ISNs’ biomedical applications in biosensors, tumor therapy, antibacterial therapy, and others, demonstrating that ISNs have promising potential for alleviating human health.

Rescuing Nucleus Pulposus Cells From Senescence via Dual‐Functional Greigite Nanozyme to Alleviate Intervertebral Disc Degeneration

“…Previous studies have reported that iron sulfides release polysulfides and exerts excellent antibacterial properties. [ 15 , 62 , 63 , 64 , 65 ] In addition, polysulfides have also been proved to involve in the field of antiviral therapy. Unlike conventional antiviral approaches, the polysulfides released by the broad‐spectrum antiviral metastable iron sulfides (mFeS) inhibit intracellular viral replication through inhibition of lipid peroxidation and ferroptosis in cells, thus enabling effective treatment of influenza viruses.…”

Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology

“…Similar to CAT-, OXD- or SOD-catalyzed reactions various reactive oxygen species (such as hydroxyl ( • OH), hydrogen peroxide (H 2 O 2 ), superoxide ( • O 2 *) and singlet oxygen ( 1 O 2 ) are formed in reactions catalyzed by these colloids ( Kantar et al, 2019 ; Nie et al, 2019 ; Ding W. et al, 2020 ; Agnihotri et al, 2020 ; Wang et al, 2020 ; Huang et al, 2021 ; Ren et al, 2021 ; Song et al, 2022 ). Since most of these ROS trigger cytotoxic effects, metal sulfide nanocolloids may provide a novel therapeutic function ( Yuan et al, 2020 ; Shan et al, 2022 ).…”

Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics

“…Recent advancements in synthesizing various inorganic nanoparticles, attributed to their intrinsic enzyme-like activity, have found wide applications in biomedicine. 25 , 26 , 27 , 50 , 51 , 423 , 424 Fe 2 O 3 nanocubes exhibit enhanced POD activity under visible light, enabling a photo-assisted colorimetric method for detecting glucose at low concentrations (0.1 mM detection limit). 74 Ferrihydrite NPs, possessing CAT activity, enhance the effectiveness of radiotherapy, 49 while magnetoferritin NPs target and visualize tumor tissues due to the iron oxide core catalyzing the oxidation of peroxidase substrates in the presence of hydrogen peroxide, producing a color reaction used to visualize tumor tissues.…”