Biomedical Applications of Laponite®-Based Nanomaterials and Formulations

Samoylenko, O.; Korotych, Olena; Manilo, Maryna; Samchenko, Yu. M.; Shlyakhovenko, V A; Lebovka, Nikolaï

doi:10.1007/978-3-030-80924-9_15

Cited by 11 publications

(17 citation statements)

References 296 publications

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“…This value corresponds to the orientationally averaged sizes of Lap platelets with a diameter of ≈25 nm and a thickness of ≈1 nm. 8 Even for the smallest degree of acid activation (Sample S 1 ), the average particle size increased by about an order of magnitude. Moreover, the bimodal distribution with the intensive maximum at d ≈ 57 nm and less intensive maximum at d ≈ 205 nm was observed (Figure 5a).…”

Section: ■ Results and Discussionmentioning

confidence: 94%

“…The side group of polyNIPAAm contains both hydrophilic (amide) and hydrophobic (isopropyl) groups in each monomer unit. 8 NIPAAm-based hydrogels belong to the important thermosensitive group with the coil-to-globule phase transition at a lower critical solution temperature (LCST) of about T d ≈ 32 °C that is very close to the temperature of the human body. 41 Below deswelling temperature T d , the formation of strong hydrogen bonds between water molecules and hydrophilic groups of the cross-linked polymer exceeds the unfavorable free energy associated with exposure of hydrophobic groups to water.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Lap nanoplatelets have a diameter of ≈25 nm, a thickness of ≈1 nm, and a cation exchange capacity of 0.7 mmol/g. 8 N-Isopropylacrylamide (NIPAAm; Merck, 97%) was recrystallized from hexane and dried under vacuum. Ammonium persulfate (NH 4 ) 2 S 2 O 8 (APS; Sigma-Aldrich, 98%), N,N,N′,N′-tetramethylethylenediamine (TEMED; Sigma-Aldrich, 99%), and sulfuric acid H 2 SO 4 (Sigma-Aldrich, 95−97%) were used as received without further purification.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…These effects can reflect the formation of "house of cards" arrangements and various spatial structures typical for nanoplatelets with complex surface charge distribution. 8 Various modifications of the surface structure of cross-linking nanoplatelets can significantly affect the properties of hydrogels. Particularly, a similar shift of T d toward lower temperatures was observed in the physically cross-linked hydrogels based on polyNIPAAm and magnetically decorated Lap particles.…”

Section: ■ Conclusionmentioning

confidence: 99%

“…15 The acid activation, intercalation, modification with organic molecules, covalent functionalization, grafting, and pillaring have been also tested. 8 Particularly, the acid activation in hydrochloric (HCl) or sulfuric (H 2 SO 4 ) acids was used to prepare the acid-activated Lap (aLap). 16 During acid activation, the protons can penetrate into the Lap layers and attack the structural OH groups.…”

Section: ■ Introductionmentioning

confidence: 99%

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Cross-Linked Hydrogels Based on PolyNIPAAm and Acid-Activated Laponite RD: Swelling and Tunable Thermosensitivity

et al. 2022

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The effects of acid activation of Laponite RD (Lap) on the structure and properties of activated Lap nanoparticles (aLap) and the properties of polyNIPAA m hydrogels physically cross-linked by aLap have been studied. The acid activation of Lap by the sulfuric acid was done using the concentration of sulfuric acid within the interval C a = 0.525−14.58% for 10 h. For slightly activated samples (C a ≤ 1.25 wt %), the significant increase of the specific surface area (by ≈1.56 times) was accompanied with a significant decrease in both the values of the specific heat of immersion in water and n-decane. However, the hydrophilic properties of all samples S 0 −S 5 were still observed. Thermogravimetric analysis (TGA) and differential thermal analysis (DTA) data, Fourier transform infrared (FTIR) spectra, and X-ray diffraction (XRD) patterns demonstrated that the acid activation resulted in the destruction of the crystal lattice of Lap, leaching of magnesium and lithium, and formation of the amorphous phases. Moreover, the acid activation significantly affected aggregation and negative surface charges of the aLap faces in aqueous suspension. The effects of aLap on the swelling properties and cooperativity in the phase transitions of polyNIPAA m hydrogels cross-linked by aLap are also discussed. It was demonstrated that an increase in C a resulted in a significant increase in the equilibrium degree of swelling of the hydrogels and a decrease in the hydrogel phase-transition temperature from the swollen phase to the shrunken phase.

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Section: ■ Results and Discussionmentioning

confidence: 94%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Conclusionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Cross-Linked Hydrogels Based on PolyNIPAAm and Acid-Activated Laponite RD: Swelling and Tunable Thermosensitivity

et al. 2022

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Physico‐Chemical Properties of Laponite®/Polyethylene‐oxide Based Composites

Lysenkov

Klepko

Bulavin

et al. 2023

The Chemical Record

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This review aims to provide a literature overview as well as the authors’ personal account to the studies of Laponite® (Lap)/Polyethylene‐oxide (PEO) based composite materials and their applications. These composites can be prepared over a wide range of their mutual concentrations, they are highly water soluble, and have many useful physico‐chemical properties. To the readers’ convenience, the contents are subdivided into different sections, related with consideration of PEO properties and its solubility in water, behavior of Lap systems(structure of Lap‐platelets, properties of aqueous dispersions of Lap and aging effects in them), analyzing ofproperties LAP/PEO systems, Lap platelets‐PEO interactions, adsorption mechanisms, aging effects, aggregation and electrokinetic properties. The different applications of Lap/PEO composites are reviewed. These applications include Lap/PEO based electrolytes for lithium polymer batteries, electrospun nanofibers, environmental, biomedical and biotechnology engineering. Both Lap and PEO are highly biocompatible with living systems and they are non‐toxic, non‐yellowing, and non‐inflammable. Medical applications of Lap/PEO composites in bio‐sensing, tissue engineering, drug delivery, cell proliferation, and wound dressings are also discussed.

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