Biomedical Applications of LIBS

radioactive, high temperature, toxic materials) [19][20][21][22][23][24][25], industry [26][27][28][29][30][31], architecture, medical (noninvasive study of human teeth and hair, diagnosis of cancer tissue, DNA analysis) [32][33][34][35][36][37], military and civil security (detection of explosive material and biological weapons) [38][39][40][41][42][43]. Most of these applications are investigated under the condition of earth's atmosphere (i.e., at 760 Torr in air atmosphere) in order to determine the selected material compositions. Nevertheless, interest in LIBS in other ambient gases with various circumstances has been grown because of its practical application. It should be mentioned that nowadays wide applications of gas effects in space exploration (such as utilizing LIBS for investigating specific conditions on Venus and Mars) [4,44,45] are studied. For instance, in scope of gas pressure, the high-pressure environment serves to replicate the conditions of a nuclear reactor or simulate some planet environments [46]. At the opposite, reduced gas pressures or vacuum is applied for determination of isotope ratios [47][48][49], synthesis of nanoparticles and thin films.Different research groups [50][51][52][53][54][55] have investigated the quantitative analysis of plasma parameters and spectral line properties in LIBS technique by considering the influences of gas conditions. For instance, Effenberger et al. [56] have properly presented a review of applications of different gas effects in LIBS experiment. They have comprehensively mentioned the results of various groups about the effects of atmosphere compositions and gas pressures (higher and lower than 760 Torr) on plasma parameters and spectral line characteristics. Dawood et al. [57] have investigated the effects of gas nature and its pressure on temporal distribution of aluminum plasma. They have explained that both plasma temperature and electron density grow with ambient gas pressure. In addition, they have shown that argon provides the highest temperature and plasma density, helium provides the lowest one, and nitrogen produces Abstract In this paper, the influences of He ambient gas on aluminum emissions are investigated by experimental analysis of LIBS spectrum. Plasma is produced by focusing of a Nd:YAG laser pulse at a wavelength of 1064 nm on Al standard samples. In this work, the effects of helium atmosphere at different pressures on the amount of spectral self-absorption are studied. The results are discussed by utilizing two approaches: the curve of growth and calibration curve. It is seen that by increasing the gas pressure, the self-absorption enhances. Also, a new method of applying one standard sample instead of other traditional techniques is introduced for concentration prediction. The presented method would be helpful for the situation in which supplying standard samples is not very easy. Then, the accuracy of this new method can be checked by comparison of concentration prediction of the standard samples with their real concentrations.

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confidence: 99%

Quantitative analysis of aluminum samples in He ambient gas at different pressures in a thick LIBS plasma

Rezaei

Tavassoli

2015

Appl. Phys. B

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“…Many applications of LIBS in the analysis of biological materials [48][49][50][51][52][53][54][55], cultural heritage and archaeology [56][57][58][59][60][61][62], industry [63][64][65], and environment [66][67][68][69] have been reported.…”

Section: -2021: XXI Century Libsmentioning

confidence: 99%

Forty Years of Laser-Induced Breakdown Spectroscopy and Laser and Particle Beams

Palleschi

2023

Laser Part. Beams

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The laser-induced breakdown spectroscopy (LIBS) technique is one of the most promising laser-based analytical techniques. Coincidentally, the LIBS acronym was proposed by Radziemski and Loree in two seminal papers published in 1981, almost at the same time in which the Laser and Particle Beams journal started its publication. In this contribution, the evolution of the LIBS technique is discussed following a chronological collection of key papers in LIBS, some of which were in fact published on LPB.

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“…The use of laser-induced breakdown spectroscopy (LIBS) as a powerful and flexible analytic tool for the rapid analysis and characterization of a specimen's elemental composition has been investigated and reported on by a growing international community for approximately the last thirty years. The results of these investigations have been widely published and disseminated and their broad conclusions have been summarized in a string of excellent monographs [1,2,3,4] and review articles [5,6,7,8,9] which have endeavored to advance the overall knowledge of the field.…”

Section: Overviewmentioning

confidence: 99%

“…Of particular importance to our group has been the investigation of the applicability and utility of LIBS in medical science, particularly as a pathology/histology laboratory tool or as a rapid point-of-contact assessment diagnostic. This topic, which is sometimes broadly classified into the area of "biomedical applications," has also received significant attention and has been summarized and reviewed in numerous outlets [18,19,20,21,22].…”

Section: Overviewmentioning

confidence: 99%

A review of the use of laser-induced breakdown spectroscopy for bacterial classification, quantification, and identification

Rehse

2019

Spectrochimica Acta Part B: Atomic Spectroscopy

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The use of laser-induced breakdown spectroscopy to determine the elemental composition of bacterial cells has been described in the peer-reviewed literature since 2003. Fifteen years on, significant accomplishments have been reported that have served to clarify and underscore the areas of bacteriological investigation that LIBS is well-suited for as well as the challenges that yet remain to be faced. This review will attempt to summarize the state of the field by surveying the available body of knowledge. The early days of these experiments, roughly from 2003 to 2007, in which many of the most fundamental experiments were initially conducted will be described. The more in-depth investigations that followed in the subsequent decade will then be detailed. Many important aspects of performing LIBS on bacterial cells were reported on and are summarized here including: the use of chemometric algorithms for statistical classification of unknown spectra; the influence of the mounting substrate on classification; the effect of the testing gas atmosphere and the choice of bacterial cell growth nutrient medium on the measured LIBS spectrum; the efficacy of a LIBS-based test as a genus-level or strainlevel discrimination test; the ability of LIBS to determine the cell titer or concentration of cells in the initial sample; the effects that possible contaminations or interferents within the sample would have on the LIBS spectrum; the influence that environmental stresses the cells may be exposed to during growth and the state of reproductive health of the cells could have on the LIBS spectrum; the use of standoff or remote apparatus to minimize the risk to the operators during bacteriological identification of unknown specimens; and the combination of other optical modalities with LIBS to enhance the sensitivity or specificity of identification. Lastly, tables are provided which summarize both every species of bacteria ever tested with LIBS as well as the major lessons learned by the community through 15 years of careful investigation. laser-induced breakdown spectroscopy; pathogens; bacteria

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Biomedical Applications of LIBS

Cited by 12 publications

References 110 publications

Quantitative analysis of aluminum samples in He ambient gas at different pressures in a thick LIBS plasma

Quantitative analysis of aluminum samples in He ambient gas at different pressures in a thick LIBS plasma

Forty Years of Laser-Induced Breakdown Spectroscopy and Laser and Particle Beams

A review of the use of laser-induced breakdown spectroscopy for bacterial classification, quantification, and identification

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