Biomedical Applications of Mycosporine‐Like Amino Acids

Richa, .; Sinha, Rajeshwar P.

doi:10.1002/9783527665259.ch27

Cited by 6 publications

(1 citation statement)

References 130 publications

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“…Together with anticancerous, antiaging and antiinflammatory activity, MAAs give protection from sunburn, erythema and edema (Richa and Sinha, 2013). MAAs shows commercial potential for food, cosmetics and biomedical research.…”

Section: Discussionmentioning

confidence: 99%

Mycosporine-Like Amino Acids (MAAs) Profile of cyanobacteria from Different Historical Kunds of Varanasi, India

Mishra¹,

Pandey²,

Ahmed³

et al. 2019

Int J Appl Sci Biotechnol

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Copious facts have demonstrated that UV radiation is harmful to cyanobacteria. Sun-screening compounds such as mycosporine-like amino acids (MAAs) protect these organisms from deleterious UV radiation. MAAs absorb UV radiation in the range of 310 to 362 nm. These natural sunscreens obtained from cyanobacteria are excellent alternative to present day synthetic UV filters. In the present study, several cyanobacteria were collected from six historical Kunds of Varanasi, India. MAAs profile of these cyanobacteria was recorded with the help of UV-Vis spectroscopy, High performance liquid chromatography (HPLC) and Fourier transform infrared (FTIR) analysis. Various MAAs were identified as Porphyra-334 (λmax = 334 nm), Palythine (λmax = 320 nm), Asterina-330 (λmax = 330 nm), Mycosporine-glycine (λmax =310 nm) and Mycosporine-methylamine-serine (λmax =327 nm) having retention times (RT) of 3.62, 1.65, 1.53, 2.55 and 1.51 min, respectively, obtained from different cyanobacteria (Microcystis aeruginosa, Anabaenopsis sp., Merismopedia sp., Aulosira fertilissima, Rivularia sp., Phormidium sp., Nostoc sp. and Stigonema sp.). It is concluded that these MAAs from different historical Kunds may provide protection to the cyanobacteria growing thereof from the adverse effect of harmful UV radiation. MAAs are considered to be potential bioactive compounds that are highly intriguing from biotechnological perspective. Int. J. Appl. Sci. Biotechnol. Vol 7(3): 317-326

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Section: Discussionmentioning

confidence: 99%

Mycosporine-Like Amino Acids (MAAs) Profile of cyanobacteria from Different Historical Kunds of Varanasi, India

Mishra¹,

Pandey²,

Ahmed³

et al. 2019

Int J Appl Sci Biotechnol

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Potential Applications of Natural Bioactive Cyanobacterial UV ‐Protective Compounds

et al. 2018

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Physiological Aspects of UV-Excitation of DNA

Richa

Sinha

Häder

2014

Photoinduced Phenomena in Nucleic Acids II

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Solar ultraviolet (UV) radiation, mainly UV-B (280-315 nm), is one of the most potent genotoxic agents that adversely affects living organisms by altering their genomic stability. DNA through its nucleobases has absorption maxima in the UV region and is therefore the main target of the deleterious radiation. The main biological relevance of UV radiation lies in the formation of several cytotoxic and mutagenic DNA lesions such as cyclobutane pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and their Dewar valence isomers (DEWs), as well as DNA strand breaks. However, to counteract these DNA lesions, organisms have developed a number of highly conserved repair mechanisms such as photoreactivation, excision repair, and mismatch repair (MMR). Photoreactivation involving the enzyme photolyase is the most frequently used repair mechanism in a number of organisms. Excision repair can be classified as base excision repair (BER) and nucleotide excision repair (NER) involving a number of glycosylases and polymerases, respectively. In addition to this, double-strand break repair, SOS response, cell-cycle checkpoints, and programmed cell death (apoptosis) are also operative in various organisms to ensure genomic stability. This review concentrates on the UV-induced DNA damage and the associated repair mechanisms as well as various damage detection methods.

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Biomedical Applications of Mycosporine‐Like Amino Acids

Cited by 6 publications

References 130 publications

Mycosporine-Like Amino Acids (MAAs) Profile of cyanobacteria from Different Historical Kunds of Varanasi, India

Mycosporine-Like Amino Acids (MAAs) Profile of cyanobacteria from Different Historical Kunds of Varanasi, India

Potential Applications of Natural Bioactive Cyanobacterial UV ‐Protective Compounds

Physiological Aspects of UV-Excitation of DNA

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