Biomedical applications of polyelectrolyte coated spherical gold nanoparticles

Abstract

Surface modified gold nanoparticles are becoming more and more popular for use in biomaterials due to the possibility for specific targeting and increased biocompatibility. This review provides a summary of the recent literature surrounding polyelectrolyte coatings on spherical gold nanoparticles and their potential biomedical applications. The synthesis and layer-by layer coating approach are briefly discussed together with common characterisation methods. The potential applications and recent developments in drug delivery, gene therapy, photothermal therapy and imaging are summarized as well as the effects on cellular uptake and toxicity. Finally, the future outlook for polyelectrolyte coated gold nanoparticles is explored, focusing on their use in biomedicine.

Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

“…Specifically, CT is a non-invasive clinical diagnostic tool that can perform 3D visual reconstruction and tissue segmentation ( Lusic and Grinstaff, 2013 ). The images of CT are composed of X-ray images, which are taken at different angles by rotating around an object to form a cross-sectional 3D image called a CT scan ( Lusic and Grinstaff, 2013 ; Fuller and Köper, 2019 ). According to the content of the images, the contrast agent can attenuate the X-ray to improve the image quality to highlight the specific area, such as the structure of blood vessels or organs ( Lusic and Grinstaff, 2013 ).…”

Exploration of the Antimicrobial and Catalytic Properties of Gold Nanoparticles Greenly Synthesized by Cryptolepis buchanani Roem. and Schult Extract

“…Hence, it was used as a spectroscopic signature to show the formation of AuNPs. In general, the characteristic surface plasmon band from 500 to 550 nm indicates the spherical shape of AuNPs [45].…”

Chirality control of inorganic materials and metals by peptides or amino acids

“…For precise control of exposed high-index facets, seed-mediated synthesis using an organothiol additive as the shape modifier was implemented. [91][92][93][94][95][96] With the addition of chiral additives, the enantioselective interaction between the L-peptide with the generated high-Miller-index facet shifts the boundaries of adjacent facets with different chirality as growth proceeds. This asymmetric growth results in the breaking of mirror and inversion symmetry to generate the 432-point group symmetry, which is therefore named the 432 helicoid series.…”