Biomedical Applications of Silver Nanoparticles (Review)

Реджепов, Довлет Таганович; Водяшкин, Андрей Алексеевич; Сергородцева, Антонина Витальевна; Станишевский, Ярослав Михайлович

doi:10.33380/2305-2066-2021-10-3-176-187

Cited by 6 publications

(3 citation statements)

References 83 publications

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“…It can be used to create devices, modify surfaces, as implants, and for other purposes [7]. In recent years, methods for applying metal nanoparticles [8], intermetallides, and polymers [9] to solve the problems of various spectra in the biomedical industry have become relevant.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Chemical Properties of Sr-BDC<sub>∞</sub> Metal-Organic Framework (MOF)

Vodyashkin,

Kezimana,

Mbarga

et al. 2024

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. In this work, Sr-BDC MOFs were obtained by a simple solvothermal process without the use of elevated pressure. This method is easily scalable and does not require any special equipment. In this work, the crystals obtained from the synthesis were studied by Raman spectroscopy. In addition, the obtained materials were analysed for antibacterial activity against Gram-positive and against Gram-negative bacteria.Aim. During this work, the main objective was to comparatively evaluate the antibacterial properties of Sr-BDC MOFs activated by different methods (and without activation).Materials and methods. In this work we used a solvothermal process using terephthalic acid, strontium nitrate and dimethylformamide. The peculiarity of this method is the absence of autoclaving in the synthesis process. Optical microscopy and Raman spectroscopy were used for characterization. Also, to study the antibacterial properties, a medium diffusion test was performed. The combination of these methods will help to establish the relationship between the method of activation and the biological activity of the resulting materials.Results and discussion. In this work, the chemical structure of Sr-BDC MOFs was studied by Raman spectroscopy. The influence of the activation method on the chemical structure of MOFs was studied. It was found that the characteristic peaks of Raman spectroscopy can be used to confirm the removal of solvent (DMFA) from the crystal structure. In addition, tests on the manifestation of antibacterial activity were carried out for MOFs with different activation method. The MIC and MBC were established for each sample.Conclusion. In the course of the work the effect of the activation method on the chemical structure of Sr-BDC MOFs was shown. We also found that the activation method could affect the biological activity of the obtained MOFs. It was also demonstrated that MOFs exhibit different antibacterial activities depending on the type of bacteria, which can be primarily related to the composition of the cell wall of microorganisms.

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Section: Introductionmentioning

confidence: 99%

Antibacterial and Chemical Properties of Sr-BDC<sub>∞</sub> Metal-Organic Framework (MOF)

Vodyashkin,

Kezimana,

Mbarga

et al. 2024

Razrabotka i registraciâ lekarstvennyh sredstv

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“…Nanoparticles are a relatively new material in the medical field, but over the years they have become more and more relevant, since they have a very wide range of applications due to their different nature. Metal nanoparticles can be actively used as antibacterial, cytotoxic, and diagnostic materials [7][8][9][10]. Polymer nanoparticles can also be used as drug delivery systems to diagnose and treat various diseases [4,11].…”

Section: Introductionmentioning

confidence: 99%

Metal-Organic Framework (MOF)—A Universal Material for Biomedicine

Vodyashkin

Sergorodceva

Kezimana

et al. 2023

IJMS

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Metal-organic frameworks (MOFs) are a very promising platform for applications in various industries. In recent years, a variety of methods have been developed for the preparation and modification of MOFs, providing a wide range of materials for different applications in life science. Despite the wide range of different MOFs in terms of properties/sizes/chemical nature, they have not found wide application in biomedical practices at present. In this review, we look at the main methods for the preparation of MOFs that can ensure biomedical applications. In addition, we also review the available options for tuning the key parameters, such as size, morphology, and porosity, which are crucial for the use of MOFs in biomedical systems. This review also analyses possible applications for MOFs of different natures. Their high porosity allows the use of MOFs as universal carriers for different therapeutic molecules in the human body. The wide range of chemical species involved in the synthesis of MOFs makes it possible to enhance targeting and prolongation, as well as to create delivery systems that are sensitive to various factors. In addition, we also highlight how injectable, oral, and even ocular delivery systems based on MOFs can be used. The possibility of using MOFs as therapeutic agents and sensitizers in photodynamic, photothermal, and sonodynamic therapy was also reviewed. MOFs have demonstrated high selectivity in various diagnostic systems, making them promising for future applications. The present review aims to systematize the main ways of modifying MOFs, as well as the biomedical applications of various systems based on MOFs.

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“…Attempts have been made to combine nanomaterials and modern antimicrobial drugs which exhibit synergism and improve the effect several times over [ 4 ]. In addition, new therapies based on targeted drug delivery [ 5 ] and nanoparticle-activated photothermal therapy are being actively investigated [ 6 ], as well as their potential for use in tissue and tumor imaging applications [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials

Zykova,

Volikov,

Buyko

et al. 2023

Polymers

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The current article describes the biological activity of new biomaterials combining the “green” properties of humic substances (HSs) and silver nanoparticles. The aim is to investigate the antioxidant activity (AOA) of HS matrices (macroligands) and AgNPs stabilized with humic macroligands (HS-AgNPs). The unique chemical feature of HSs makes them very promising ligands (matrices) for AgNP stabilization. HSs have previously been shown to exert many pharmacological effects mediated by their AOA. AgNPs stabilized with HS showed a pronounced ability to bind to reactive oxygen species (ROS) in the test with ABTS. Also, higher AOA was observed for HS-AgNPs as compared to the HS matrices. In vitro cytotoxicity studies have shown that the stabilization of AgNPs with the HS matrices reduces the cytotoxicity of AgNPs. As a result of in vitro experiments with the use of 2,7-dichlorodihydrofluorescein diacetate (DCFDA), it was found that all HS materials tested and the HS-AgNPs did not exhibit prooxidant effects. Moreover, more pronounced AOA was shown for HS-AgNP samples as compared to the original HS matrices. Two putative mechanisms of the pronounced AOA of the tested compositions are proposed: firstly, the pronounced ability of HSs to inactivate ROS and, secondly, the large surface area and surface-to-volume ratio of HS-AgNPs, which facilitate electron transfer and mitigate kinetic barriers to the reduction reaction. As a result, the antioxidant properties of the tested HS-AgNPs might be of particular interest for biomedical applications aimed at inhibiting the growth of bacteria and viruses and the healing of purulent wounds.

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Biomedical Applications of Silver Nanoparticles (Review)

Cited by 6 publications

References 83 publications

Antibacterial and Chemical Properties of Sr-BDC<sub>∞</sub> Metal-Organic Framework (MOF)

Antibacterial and Chemical Properties of Sr-BDC<sub>∞</sub> Metal-Organic Framework (MOF)

Metal-Organic Framework (MOF)—A Universal Material for Biomedicine

Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials

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