Biomedical Applications of Terahertz Spectroscopy and Imaging

Xiang, Yang; Zhao, Xiang; Yang, Ke; Liu, Yueping; Liu, Yu; Fu, Weiling; Luo, Yang

doi:10.1016/j.tibtech.2016.04.008

Cited by 753 publications

(381 citation statements)

References 104 publications

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“…Recent developments in terahertz (THz, 0.1-10 THz) biomedical applications have garnered much interest in label-free research, owing to its unique spectral advantages [14][15][16][17]. THz photon energy meshes well with the energy levels of low-frequency molecular motions including rotation, vibration, and relative translation of the molecular skeleton, and particularly the hydrogen bonds between biomolecules and water [18].…”

Section: Introductionmentioning

confidence: 99%

Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy

Zhao

Zhang

Wei

et al. 2017

Biomed. Opt. Express

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Abstract:The aptamer and target molecule binding reaction has been widely applied for construction of aptasensors, most of which are labeled methods. In contrast, terahertz technology proves to be a label-free sensing tool for biomedical applications. We utilize terahertz absorption spectroscopy and molecular dynamics simulation to investigate the variation of binding-induced collective vibration of hydrogen bond network in a mixed solution of MUC1 peptide and anti-MUC1 aptamer. The results show that binding-induced alterations of hydrogen bond numbers could be sensitively reflected by the variation of terahertz absorption coefficients of the mixed solution in a customized fluidic chip. The minimal detectable concentration is determined as 1 pmol/μL, which is approximately equal to the optimal immobilized concentration of aptasensors. 575-579 (2012). 33. J.-J. Max and C. Chapados, "IR spectroscopy of aqueous alkali halide solutions: pure salt-solvated water spectra and hydration numbers," J.

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Section: Introductionmentioning

confidence: 99%

Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy

Zhao

Zhang

Wei

et al. 2017

Biomed. Opt. Express

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“…The main feature of THz spectroscopy which is really important for biophotonics is that the characteristic energies of molecules rotational and vibrational motions lay in THz frequency region, so many chemical and biological molecules can be identified by their characteristic resonant peaks [5]. Also THz radiation is very sensitive to water [6], so it could provide a great contrast of samples with different water content.…”

Section: Introductionmentioning

confidence: 99%

Study of glucose concentration influence on blood optical properties in THz frequency range

Gusev¹,

Demchenko²,

Litvinov³

et al. 2018

Nanosystems: Phys. Chem. Math.

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The optical properties of whole human blood with the different glucose level were studied by terahertz time-domain spectroscopy at frequencies ranging from 0.3 -0.5 THz. The increasing of refractive index of blood at the glucose level growth was shown for series of experiments. The dispersion of complex refractive index of human nails was obtained. Based on these data, the non-invasive glucose measuring technique was proposed which utilizes the reflection of the THz pulse from nail plate/nail bed interface.

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“…[1][2][3][4] One of those unique features is the spectral fingerprint that many materials possess in these frequencies, 5,6 which can be exploited for nondestructive imaging applications such as biomedical, materials inspection, and security. [7][8][9] Therefore, high spatial resolution imaging at a specific frequency of interest is a highly desirable capability in THz imaging applications.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of spatial resolution of terahertz imaging systems based on terajet generation by dielectric cube

et al. 2017

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The terahertz (THz, 0.1–10 THz) region has been attracting tremendous research interest owing to its potential in practical applications such as biomedical, material inspection, and nondestructive imaging. Those applications require enhancing the spatial resolution at a specific frequency of interest. A variety of resolution-enhancement techniques have been proposed, such as near-field scanning probes, surface plasmons, and aspheric lenses. Here, we demonstrate for the first time that a mesoscale dielectric cube can be exploited as a novel resolution enhancer by simply placing it at the focused imaging point of a continuous wave THz imaging system. The operating principle of this enhancer is based on the generation—by the dielectric cuboid—of the so-called terajet, a photonic jet in the THz region. A subwavelength hotspot is obtained by placing a Teflon cube, with a 1.46 refractive index, at the imaging point of the imaging system, regardless of the numerical aperture (NA). The generated terajet at 125 GHz is experimentally characterized, using our unique THz-wave visualization system. The full width at half maximum (FWHM) of the hotspot obtained by placing the enhancer at the focal point of a mirror with a measured NA of 0.55 is approximately 0.55λ, which is even better than the FWHM obtained by a conventional focusing device with the ideal maximum numerical aperture (NA = 1) in air. Nondestructive subwavelength-resolution imaging demonstrations of a Suica integrated circuit card, which is used as a common fare card for trains in Japan, and an aluminum plate with 0.63λ trenches are presented. The amplitude and phase images obtained with the enhancer at 125 GHz can clearly resolve both the air-trenches on the aluminum plate and the card’s inner electronic circuitry, whereas the images obtained without the enhancer are blurred because of insufficient resolution. An increase of the image contrast by a factor of 4.4 was also obtained using the enhancer.

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Biomedical Applications of Terahertz Spectroscopy and Imaging

Cited by 753 publications

References 104 publications

Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy

Label-free sensing of the binding state of MUC1 peptide and anti-MUC1 aptamer solution in fluidic chip by terahertz spectroscopy

Study of glucose concentration influence on blood optical properties in THz frequency range

Enhancement of spatial resolution of terahertz imaging systems based on terajet generation by dielectric cube

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