Biomedical Effects of Cinnamon Extract on Obesity and Diabetes Relevance in Wistar Rats

Soliman, Mohamed Mohamed; Attia, Hossam Fouad; El-Shazly, Samir Ahmed; Saleh, Osama

doi:10.3923/ajbmb.2012.133.145

Cited by 24 publications

(13 citation statements)

References 23 publications

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“…STZ administration induced dyslipidemia, while, stevioside normalized the increase in cholesterol and TG and the decrease in HDL with changes in CPT-1 mRNA expression. Similar findings were reported by (Soliman et al 2012) for cinnamon extract useful medication for diabetes treatment. HDLcholesterol is good for health, since it facilitates mobilization of triglycerides and cholesterol from the plasma to the liver (Miller et al 1985).…”

Section: Effect Of Stevioside On Pancreas Histology and Immunohistochsupporting

confidence: 79%

“…Twenty rats were handled and divided into 2 groups control (CNT) without any treatment and control plus stevioside (CNT + ST) received stevioside 300 mg/kg B.W based on study of (Singh et al, 2013) for 4 weeks. Remaining thirty rats were injected intraperitoneally by STZ in a dose of 60 mg/kg B.W in citrate buffer after overnight fasting (Soliman et al 2012). To avoid sudden death due to hypoglycemia, rats supplemented with 5% glucose solution for the next 12 hrs.…”

Section: Animals Experimental Design and Samplingmentioning

confidence: 99%

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Insulin-mimetic activity of stevioside on diabetic rats: biochemical, molecular and histopathological study

Saleh¹,

Awad²,

Soliman³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Stevioside has been used as a medication for reducing glucose levels in diabetic patients. The exact mode of action is still unclear. Therefore, the current study outlined the molecular and biological roles of stevioside in treatment of diabetes. Materials and Methods: Diabetic male Wistar rats were treated with stevioside and metformin as a medication for diabetes rats for 4 weeks. Biochemical, molecular and histopathological studies have been done to evaluate the therapeutic effect of stevioside on minimizing levels of glucose and its related gene expression in diabetic rats. Results: Stevioside administration normalized kidney and liver biomarkers, restored alterations in antioxidants activity and lipid profiles. Moreover, stevioside increased insulin and leptin secretion that are decreased in diabetic rats to the normal levels. For mRNA expression, stevioside up-regulated the expressions of PK and IRS-1 genes, which are down-regulated in diabetic rats, and was very effective in the down-regulation of CPT-1 mRNA expression. At the cellular levels; stevioside normalized the histopathological changes induced in pancreas. Conclusion: Stevioside has insulin like effects and is useful for diabetic patient's therapy.

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Section: Effect Of Stevioside On Pancreas Histology and Immunohistochsupporting

confidence: 79%

Section: Animals Experimental Design and Samplingmentioning

confidence: 99%

Insulin-mimetic activity of stevioside on diabetic rats: biochemical, molecular and histopathological study

Saleh¹,

Awad²,

Soliman³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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“…Several studies were said that the active combinations of cinnamon (such as cinnam aldehyde, eugenol and other compounds) possess extensive ranges of pharmacological effects that seems to be highly bioactive against diabetes by its effect on insulin secretion and stimulate glucose uptake by hepatocytes and adipocytes (12,13). Therefore, in many studies, experimental animals rats or mice were subjected to diabetes by alloxan or other drugs (14) to learning the role of cinnamon on blood glucose and its uptake by tissues with examining of histological changes in these animals (15,16). The genus cinnamomum comprises of about 250 species (17).…”

Section: Introductionmentioning

confidence: 99%

11-Effect of Cinnamon Zeylanicum Bark Water Extract on Male Diabetic Albino Rats Fertility

J.H.AL-Khamas¹

2018

Bas.J.Vet.Res.

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The effects of Cinnamon zeylanicum (CZ) bark extracts on productivity of male diabetic albino rats testosterone stages were studied. The experimentation was carried out on 24 male albino rats allocated into 4 equivalent groups of 6 animals each. One group was served as a normal control, whereas rats of the groups (2) were given Alloxan (120 mg.B.W / day for 3 days) by intraperitoneal injection for induction of diabetes was leftward as a diabetic control, while rats of groups (3) CZ extract treated by 500 mg.kg B.W.orally, while rats of groups (4) CZ extract treated 500 mg. BW orally,for 6 weeks without alloxan treatment. Results showed that oral administration of CZ extracts to diabetic rats for 6 weeks significant increased serum testosterone levels. The dose of extracts ameliorated the degenerative lesions which found in diabetic rats testes, This study recommend that drinking of CZ bark as a extract may be beneficial for diabetic patients who suffer from sexual impotency as it improve fertility and lessen the high blood glucose level in male diabetic rats.

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“…After the acclimatization period, eight rats were fed with standard laboratory rat diet containing 26.5% protein, 3.8% fat, 40% carbohydrate, and 4.5% crude fiber in 100 g of chow during 24 weeks of the experimental period and served as incline control group. The other 24 rats were fed with high-cholesterol diet (HCD) containing 19.93% protein, 15% cholesterol, 57.50% carbohydrate, and 2.81% dietary fiber in 100 g of chow (modified method of Soliman et al [12]) for 12 weeks. The dietary ingredients were homogenized in distilled water and dried in an incubator at 60°C for 24 hrs and cut into small equal-sized pieces (pellets).…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Insights Into the Role of Morus Alba in Reversing Obesity-Associated Hepatic Steatosis and Related Metabolic Disorder in Rats

Ahmed¹,

Metwally²,

Rashad³

et al. 2016

Asian J Pharm Clin Res

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Objective:The goal of the present study was to examine the viability of Morus alba (M. alba) ethanolic extract in repression of obesity-associated hepatic steatosis and related metabolic disorder; dyslipidemia, hyperinsulinemia, and glycemic status. Methods:Adult female albino rats were randomly assigned into four groups, eight rats each as follows: Group (1) control group received standard rodent diet for 24 weeks. The other three groups administered high cholesterol diet for 12 weeks and served as obese group, M. alba-treated group, and simvastatin-treated group. Results:The current results showed an increment in thoracic circumference (TCX) and abdominal circumferences (AC) as well as body mass index (BMI) in obese group. In addition, dyslipidemia, hyperinsulinemia, hyperglycemia, and insulin resistance have been elucidated in obese group. Moreover, hepatic malondialdehyde (MDA), nitric oxide (NO), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin values were significantly increased in obese groups versus control group. On the other hand, administration of ethanolic extract of Morus alba or simvastatin could significantly lessen BMI and in addition to improve dyslipidemia in obese group. Glucose, insulin levels, and insulin resistance value in serum samples demonstrated a significant reduction in obese group upon treatment with M. alba ethanolic extract or simvastatin. Furthermore, noticeable depletion in hepatic MDA, NO contents, serum ALT, AST activities, and serum bilirubin level was recorded as a result of treatment with either ethanolic extract of M. alba or simvastatin. Histopathological examination of liver tissue showed ballooning degeneration in the hepatocytes (hepatic steatosis) associated with inflammatory cells penetration in portal zone in obese group. Meanwhile, the treatment of obese groups with ethanolic extract of M. alba or simvastatin was found to restore the structural organization of the liver. Conclusion:The present findings provide a novel aspect for understanding of the role of M. alba against obesity-associated liver diseases and related metabolic disorder. The mechanisms underlying these effects seem to depend on the hypolipidemic potential, anti-inflammatory property, and antioxidant activity of its phytochemicals. Metwally et al. 232chemicals used for analysis met the quality criteria in accordance with the International Standards. Plant preparation and extraction proceduresAir-dried aerial parts of M. alba Lam. were purchased from a local market in Cairo, Egypt, and the plant was identified by a botanist of the

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Biomedical Effects of Cinnamon Extract on Obesity and Diabetes Relevance in Wistar Rats

Cited by 24 publications

References 23 publications

Insulin-mimetic activity of stevioside on diabetic rats: biochemical, molecular and histopathological study

Insulin-mimetic activity of stevioside on diabetic rats: biochemical, molecular and histopathological study

11-Effect of Cinnamon Zeylanicum Bark Water Extract on Male Diabetic Albino Rats Fertility

Insights Into the Role of Morus Alba in Reversing Obesity-Associated Hepatic Steatosis and Related Metabolic Disorder in Rats

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