Biomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental research

Mohammed, Rebin Rafaat; Omer, Abdullah Khalid; Yener, Zabit; Uyar, Ahmet; Ahmed, Avin Kawa

doi:10.1016/j.amsu.2020.11.051

Cited by 42 publications

(36 citation statements)

References 35 publications

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“…Therefore, L. nobilis leaves have traditionally been used in Mediterranean cuisine [ 3 ] for seasoning, as well as in folk medicine along with L. nobilis fruits for treating viral infections, cough, rheumatism, impaired digestion, diarrhea and other health conditions [ 4 ]. Numerous scientific studies highlight the antimicrobial [ 5 , 6 ], antifungal [ 7 , 8 ], anticonvulsant [ 9 ], antioxidant [ 10 , 11 , 12 ], anti-inflammatory [ 13 , 14 ], antidiabetic [ 15 , 16 , 17 ], anticancer [ 12 , 18 ], neuroprotective [ 19 ] and anticholinergic [ 20 ] activities of L. nobilis leaf extracts and essential oils. These properties offer various application possibilities of L. nobilis extracts in the food, pharmaceutical and cosmetic industries.…”

Section: Introductionmentioning

confidence: 99%

Isolation of Laurus nobilis Leaf Polyphenols: A Review on Current Techniques and Future Perspectives

Dobroslavić

Repajić

Dragović–Uzelac

et al. 2022

Foods

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In recent years, the market demand for products enhanced with ingredients derived from natural products, such as polyphenols, is rapidly increasing. Laurus nobilis L., known as bay, sweet bay, bay laurel, Roman laurel or daphne is an evergreen Mediterranean shrub whose leaves have traditionally been used in cuisines and folk medicine due to their beneficial health effects, which can nowadays be scientifically explained by various biological activities of the leaf extracts. Many of these activities can be attributed to phenolic compounds present in L. nobilis leaves which include flavonoids, phenolic acids, tannins (proanthocyanidins) and lignans. In order to enable efficient industrial utilization of these valuable compounds, it is crucial to establish optimal extraction procedures resulting in the highest yields and quality of the extracts. This paper offers the first systematic review of current literature on the influence of conventional and advanced extraction techniques, including microwave-assisted, ultrasound-assisted, enzyme-assisted, supercritical-CO2 and mechanochemical-assisted extraction on the phenolic content of L. nobilis leaf extracts, allowing more efficient planning of further research and simplifying the steps towards industrial utilization of this plant.

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Section: Introductionmentioning

confidence: 99%

Isolation of Laurus nobilis Leaf Polyphenols: A Review on Current Techniques and Future Perspectives

Dobroslavić

Repajić

Dragović–Uzelac

et al. 2022

Foods

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“…Many studies have been published in the literature describing HILI 3,9,10 . Among the English language literature, Laurus nobilis extract has been described as having strong free radical scavenging properties that prevent the effects of toxicity and provide hepatoprotective effects in experimental animal models 11 . Interestingly, we noticed that only the hepatoprotective properties of Laurus nobilis were investigated in the literature.…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report

Kara

Bayır

Korkmaz

et al. 2021

Journal of Emergency Medicine Case Reports

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Introduction:In recent years, an increase in the use of herbal supplements, natural products, and traditional medicines has been observed. These herbs and herbal products have been associated with complications, such as liver injury, causing high mortality and morbidity.Case Report: A 51-year-old female presented to the emergency department with a 2-week history of abdominal pain, vomiting, and nascent jaundice. In the detailed history of the patient, the daily consumption of Laurus nobilis tea was reported for 1 month at home. On physical examination, she was icteric and ill-looking. Mild right upper quadrant discomfort with tenderness was noted, but no rash or hepatosplenomegaly was observed. The laboratory tests results were as follows: serum AST/ALT ratio 1.2 (908/744 U/L), gamma-glutamyl transferase 63 U/L, ALP 124 U/L, bilirubin (total/direct) 27.0/14.0 mg/dL, and lactate dehydrogenase 420 U/L. Prothrombin time international normalized ratio was 2.77. The gastroenterology department considered fulminant hepatitis in the patient and recommended liver transplantation. The patient died while preparations for the transplant were ongoing. Conclusion:Many herbal products are known to be hepatotoxic. Laurus nobilis is a commonly consumed herbal product, and the potential of this herb to cause hepatotoxicity should be considered.

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“…Polyphenols are the most abundant non-volatile bioactives in sage, wild thyme, and laurel that possess antioxidant, antimicrobial, anticarcinogenic, antifungal, antidiabetic, and anti-inflammatory effects, and some of these effects can often be enhanced due to synergistic effects among structurally diverse polyphenols [ 9 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. The synergism of mixtures of major or minor phenolics affects different pathways of the disease and contributes to faster and more effective healing [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Volatile and Volatile Bioactives of Salvia officinalis L., Thymus serpyllum L. and Laurus nobilis L. Extracts with Potential Use in the Development of Functional Beverages

et al. 2022

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Functional beverages based on herbal extracts are highly demanded products due to the presence of bioactives with promising health benefits and interesting and characteristic sensory properties. Mediterranean medicinal and aromatic herbs contain a wide range of bioactives (non-volatile polyphenols, volatile terpenes) that are important constituents of herbal extracts and essential oils. The antioxidant capacity and potential health benefits of these bioactives could be associated with their synergistic effects. Therefore, this study aimed to characterize the non-volatile and volatile bioactives of sage (Salvia officinalis L.), wild thyme (Thymus serpyllum L.) and laurel (Laurus nobilis L.) aqueous extracts and their two- and three-component mixtures as well as their antioxidant capacity. The content of total phenols, flavonoids, hydroxycinnamic acids and flavonols was determined spectrophotometrically. Individual polyphenols were analyzed by LC-MS/MS, the volatiles were analyzed by HS-SPME/GC-MS, and the antioxidant capacity was analyzed by ORAC and DPPH assays. The results showed that aqueous extracts of all examined herbs and their mixtures contained a high content of phenolic compounds ranging from 0.97 to 2.79 g L−1 of the sample, among which the most common were flavonols. At the same time, mono- and sesquiterpenes were the main volatiles. All extracts showed high antioxidant capacity, especially L. nobilis (781.62 ± 5.19 μmol TE mL−1 of the sample in the DPPH assay; 1896.10 ± 8.77 μmol TE mL−1 of the sample in the ORAC assay) and the two-component mixture of L. nobilis and T. serpyllum (679.12 ± 5.19 μmol TE mL−1 in the DPPH assay; 1913.38 ± 8.77 μmol TE mL−1 in the ORAC assay). Mixtures of herbal extracts have been shown to possess additive or synergistic effects, consequently contributing to higher antioxidant capacity. Therefore, two-component mixtures of herbal extracts showed promising potential for the production of functional beverages.

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Biomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental research

Cited by 42 publications

References 35 publications

Isolation of Laurus nobilis Leaf Polyphenols: A Review on Current Techniques and Future Perspectives

Isolation of Laurus nobilis Leaf Polyphenols: A Review on Current Techniques and Future Perspectives

Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report

Non-Volatile and Volatile Bioactives of Salvia officinalis L., Thymus serpyllum L. and Laurus nobilis L. Extracts with Potential Use in the Development of Functional Beverages

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