Biomedical ethics and clinical oversight in multisite observational neuroimaging studies with children and adolescents: The ABCD experience

Clark, Duncan B.; Fisher, Celia B.; Bookheimer, Susan Y.; Brown, Saundra A.; Evans, John H.; Hopfer, Christian J.; Hudziak, James J.; Montoya, Iván D.; Murray, Margaret; Pfefferbaum, Adolf; Yurgelun‐Todd, Deborah

doi:10.1016/j.dcn.2017.06.005

Cited by 91 publications

(67 citation statements)

References 49 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18,19 The ABCD biomedical ethics framework was developed to ensure a coherent and consistent mandate, with sufficient flexibility to ensure compliance with state- and institution-specific research ethics board requirements, and all procedures were approved by site-level institution research ethics boards. 20 All experimental procedures were in compliance with the Declaration of Helsinki and subsequent revisions.…”

Section: Methodsmentioning

confidence: 99%

Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study

Walsh

Barnes

Cameron

et al. 2018

The Lancet Child & Adolescent Health

192

157

View full text Add to dashboard Cite

Background: Childhood is a critical period for brain development, and the behaviours that comprise a typical 24-hour day contribute to cognitive performance in children. This study investigated the relationship between cognition and meeting the 24-hour movement behaviour guidelines of ≥60 minutes of physical activity, ≤2 hours of recreational screen time, and 9–11 hours of sleep per day in 9–10 year-olds. Methods: This study presents cross-sectional data from the first annual curated release of the Adolescent Brain Cognitive Development Study (ABCD) – a 10-year longitudinal, observational study investigating brain development in US children. Data were collected from 21 study sites across the United States between September 2016 and 2017. Participants were 4,524 US children aged 9–10 years. Exposures were combinations of adherence to physical activity, recreational screen time, and sleep duration recommendations and number of recommendations met. The primary outcome was global cognition and secondary outcomes were crystallized and fluid intelligence. Findings: The mean (SD) number of guideline recommendations met was 1·1 (0·9). Overall, 51·0% of participants met the sleep recommendation, 36·6% met screen time, and 17·5% met the physical activity recommendation. 70·6% of participants met at least 1, whereas 4·8% of participants met all 3 recommendations. Multi-level regression analysis revealed a statistically significant positive association between global cognition and each additional recommendation met [β=1·44 (95% CI: 0·82 – 2·07), p<0·001]. There was a statistically significant positive association between global cognition and meeting sleep + screen recommendations [β=5·15 (95% CI: 3·56 – 6·74), p<0·001] or meeting the screen-only recommendation [β=4·25 (95% CI: 2·50 – 6·01, p<0·001] compared to not meeting any recommendations. Interpretation: Meeting the recommendations of the 24-hour movement guidelines was associated with superior global cognition in this sample of US children. These findings highlight the importance of limiting recreational screen time and encouraging healthy sleep for promoting better cognition in children.

show abstract

Section: Methodsmentioning

confidence: 99%

Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study

Walsh

Barnes

Cameron

et al. 2018

The Lancet Child & Adolescent Health

192

157

View full text Add to dashboard Cite

show abstract

“…Parents or guardians provided written informed consent after the procedures had been fully explained and children assented before participation in the study. 43…”

Section: Methodsmentioning

confidence: 99%

Delineating and validating higher-order dimensions of psychopathology in the Adolescent Brain Cognitive Development (ABCD) study

Michelini

Deanna²,

Tian

et al. 2019

Preprint

View full text Add to dashboard Cite

2 6 2 7Hierarchical dimensional systems of psychopathology promise more informative descriptions for 2 8 understanding risk and predicting outcome than traditional diagnostic systems, but it is unclear how many 2 9 major dimensions they should include. We delineated the hierarchy of childhood and adult 3 0 psychopathology and validated it against clinically-relevant measures. Participants were 4,524 9-and 10-3 1year-old children and their parents from the Adolescent Brain Cognitive Development (ABCD) study. 2Factor analyses on items from the Child Behavior Checklist and Adult Self-Report characterized a 3 3 dimensional hierarchy. We examined the familial aggregation of the psychopathology dimensions, and 3 4 the ability of different factor solutions to account for risks factors, social, educational and cognitive 3 5 functioning, and physical and mental health service utilization. A hierarchical structure with a general 3 6 psychopathology ('p') factor at the apex and five specific factors (internalizing, somatoform, detachment, 3 7 neurodevelopmental, and externalizing) emerged in children. Adult factors were similar, but externalizing 3 8 behaviors separated into disinhibited and antagonistic factors. Child and parent p-factors correlated highly 3 9 (r=.61, P<.001), and smaller but significant correlations emerged for convergent dimensions between 4 0 parents and children after controlling for p-factors (r=.10-20, P<.001). A model with childhood p-factor 4 1 alone explained mental health service utilization (R 2 =.13, P<.001), but up to five dimensions provided 4 2 incremental validity to account for developmental risk and current functioning (R 2 =.03-.20, P<.001). In 4 3 this first investigation comprehensively mapping the psychopathology hierarchy in children and adults, 4 4we delineated a hierarchy of higher-order dimensions associated with a range of clinically-relevant 4 5 validators. These findings hold important implications for psychiatric nosology and future research in this 4 6 sample. 4 7 4 8 3

show abstract

“…All participants were administered assessments to obtain data on the respective youth's brain morphology, cognitive function, substance use, demographics, and environment 8 . Written informed consent was obtained from all parents, and all children provided assent to a research protocol approved by the institutional review board at each data collection site (https:// abcdstudy.org/study-sites/) 9 .…”

Section: Participantsmentioning

confidence: 99%

Parental and social factors in relation to child psychopathology, behavior, and cognitive function

et al. 2020

View full text Add to dashboard Cite

Parental and social factors have long-term impact on the neurodevelopment of offspring, but tend to highly covary with each other. Thus, it is difficult to parse out which parental and social factor contributes most to neurodevelopmental outcomes. This study aimed to assess clusters of parental and social factors associated with child psychopathology, behavioral problems, and cognition. This study employed the data of 11,875 children (9 to 11 years) from the Adolescent Brain Cognitive Development (ABCD) study. Principal component analysis (PCA) was performed on 39 environmental measures and 30 child behavior and cognitive measures separately to identify clusters of parental and social factors and clusters of child psychopathology, behaviour, and cognition. Regression analysis was used to examine independent effects of each cluster of parental and social factors on child psychopathology, behavioral problems, and cognition. Greater Parent Psychopathology cluster was associated with greater Child Psychopathology cluster. Moreover, greater Socioeconomic Status cluster was associated with greater child General Cognition and Executive Function but less Behavioral Inhibition clusters. Greater Proximal Social Environment and Interaction cluster were associated with less child Impulsive Behavior and Behavioral Inhibition, but greater Behavioral Activation cluster. The environmental clusters related to birth outcomes, maternal tobacco, and drug use were not significantly related to child psychopathology, behavior, and cognition. Our findings suggest that socioeconomic status, parental psychopathology, and social environment and interactions are the strongest risks for behavioral problems and cognitive performance in a general child population. Intervention programs should target modifiable factors within these domains.

show abstract

Biomedical ethics and clinical oversight in multisite observational neuroimaging studies with children and adolescents: The ABCD experience

Cited by 91 publications

References 49 publications

Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study

Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study

Delineating and validating higher-order dimensions of psychopathology in the Adolescent Brain Cognitive Development (ABCD) study

Parental and social factors in relation to child psychopathology, behavior, and cognitive function

Contact Info

Product

Resources

About