Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Zeng, Yun; Dou, Taotao; Ma, Lei; Ma, Jingwen

doi:10.1002/advs.202202384

Cited by 32 publications

(20 citation statements)

References 226 publications

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“…[331][332][333] PAI has been extensively used in clinical practice for tumors, disease microenvironments, lymph nodes, and gastrointestinal imaging. [26,186,334] The process of PA signal generation is as follows: when the endogenous or exogenous contrast agents in the tissue are irradiated by a pulsed laser, the contrast absorbs the laser energy and produces the ultrasonic wave. The ultrasonic wave is then transmitted from the inside of the biological tissue to the outside, and received by the ultrasonic transducer and converted into PA images.…”

Section: Pai Applications Of Bodipymentioning

confidence: 99%

BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

et al. 2023

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owing to its large molar absorption coefficients, high emission quantum yields, satisfactory chemical stability, and high tunability of photophysical properties. [10,11] The conventional BODIPY core has good structural stability, in which BF 2 -chelated inhibits the rotation around the CN pyrrole bridging bonds, which enhances the structural rigidity and endows the system with fluorescence emission properties. [12] The BODIPY core has 8 covalently modified positions, which can be divided into pyrrole ring carbons, the meso-carbon, and the boron atom. [11,13,14] These abundant active sites provide lots of possibilities to expand the structure of BODIPY derivatives through functionalization and to tune their photophysical properties. [15] In the past few decades, the structural modification strategies of BODIPY units and the resulting effects have been systematically explored, [4,16] providing a solid research foundation for the current-stage design and construction of various functional BODIPY derivatives for different occasions. After decades of development, by virtue of the high molar extinction coefficient, longer wavelength absorbing, outstanding photosensitivity, satisfactory internal stability, better biocompatibility relative to inorganic dyes, high light-dark toxicity ratios, and preferable photothermal conversion efficiency (PCE), [4,[17][18][19] there has been considerable interest in exploring the application of BODIPY as photosensitizers (PSs) in the area of phototherapy, which involves the production of reactive The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, and inspiring cutting-edge work in post-functionalization strategies is highlighted. A brief overview of assembly model of BODIPY is then provided: BODIPY is introduced as a promising building block for the formation of single-and multicomponent self-assembled systems, including nanostructures suitable for aqueous environments, thereby showing the great development potential of supramolecular assembly in biomedicine applications. The frontier progress of BODIPY in biomedical application is thereafter described, supported by examples of the frontiers of biomedical applications of BODIPY-containing smart materials: it mainly involves the application of materials based on BODIPY building blocks and their assemblies in fluorescence bioimaging, photoacoustic imaging, disease treatment including photodynamic therapy, photothermal therapy, and immunotherapy. Lastly, not only the current status of the BODIPY family in the biomedical field but also the challenges worth considering are summarized. At the same time, insights into the future development prospects of biomedically applicable BODIPY are provided.

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Section: Pai Applications Of Bodipymentioning

confidence: 99%

BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

et al. 2023

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“…High-quality imaging holds great promise for cancer diagnosis and treatment. , Near-infrared (NIR)-II fluorescence imaging, an optical imaging modality, is capable of high image resolution and real-time monitoring but suffers from low tissue penetration ability. , In contrast, photoacoustic (PA) imaging technology uses the ultrasonic wave as the carrier to obtain the optical absorption information on tissues and replaces photon detection in traditional optical imaging with ultrasonic detection, thus avoiding the problem of insufficient penetration depth caused by optical scattering, breaking through the soft limit of traditional optical imaging (about 1 mm), and realizing PA imaging of deep tissues with a depth of up to 7 cm. − However, the imaging resolution of PA is lower than fluorescence. Therefore, imaging techniques that combine NIR-II fluorescence and PA imaging afford higher-quality photographs than a single technique. , …”

Section: Introductionmentioning

confidence: 99%

Aggregation-Enhanced Photophysical Performance of D-π-A Structured Hemicyanine for NIR-II Fluorescent and Photoacoustic Imaging-Guided Photothermal Therapy

Pang

Zhao

et al. 2023

Chemical & Biomedical Imaging

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Near-infrared (NIR)-II fluorescence and photoacoustic (PA) dual-model imaging-guided photothermal therapy (PTT) can precisely diagnose and treat tumors and evaluate the therapeutic efficacy in real-time. Herein, we utilized a donor-π-acceptor (D-π-A) structured hemicyanine dye (named M1) with a large conjugated structure and strong intramolecular charge transfer effect and demonstrated that the aggregation of M1 could significantly enhance its photophysical performance by improving its photostability and photothermal conversion capability as compared with M1 in a single molecular state. Furthermore, we prepared water-dispersible NIR-II fluorescent nanoparticles (M1 NPs) by wrapping M1 with DSPE-PEG2000-NH2. The obtained M1 NPs exhibit strong NIR-I absorption and NIR-II fluorescence with their maxima at 734 and 1040 nm, respectively, with a fluorescence quantum yield of 2.84%. Moreover, M1 NPs also exhibit excellent biocompatibility, good photostability, and high photothermal conversion efficiency of 77.5%. In vitro and in vivo experiments reveal that M1 NPs can effectively image tumors through NIR-II fluorescence and PA signals, inhibit DNA replication, trigger cytoskeleton collapse, and eventually induce tumor cell apoptosis under 808 nm laser irradiation. Based on these outstanding properties, the application of M1 NPs in PA and NIR-II fluorescence imaging-guided PTT of tumors is demonstrated.

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“…The photoacoustic (PA) imaging technique, which allows non-invasive, rapid, and real-time detection of living tissues, has become a research focus in recent years. − Conventional in vivo PA imaging technique using visible light (400–700 nm) and the light in the first window of near-infrared (NIR-I, 650–980 nm) as the excitation irradiation has some non-negligible disadvantages, for instance, (1) low detection depth caused by the absorption and scattering induced by the biological tissues and (2) reduced signal-to-noise ratio stemmed from the interference induced by the autofluorescence of tissues and metabolites . In contrast, the photons in the second NIR window (NIR-II, 1000–1700 nm) have lower light power and much weaker light scattering and absorption in tissues .…”

Section: Introductionmentioning

confidence: 99%

A Cost-Effective Semiconducting Polymer with an Ether Chain-Substituted Bithiophene as the Donor Unit Enabling Effective NIR-II Photoacoustic Imaging

Jiang

Lan

Zhou

et al. 2023

ACS Appl. Polym. Mater.

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Due to their tunability in the chemical structure and light absorption, semiconducting polymers (SPs) have proven their promising potential for photoacoustic (PA) imaging within the second near-infrared (NIR-II) window. However, the syntheses of these polymers are generally lengthy and costly, limiting their potential applications. Herein, inspired by the commonly cost-effective thiophene-based compounds, we report a semiconducting polymer PTT-ATQ based on the non-fused ether chain-substituted donor unit 3,3′-bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2,2′-bithiophene (TT). With the side chain substituted by the biocompatible ether chains, the TT unit possesses an even stronger electron-donating ability and thus, a strong intramolecular charge-transfer (ICT) effect in the polymer backbone; hence, an absorption band (peaked at ca. 1370 nm) within the NIR-II window for PTT-ATQ is realized. Meanwhile, the long and bulky side chains of the donor and acceptor units lead to a non-coplanarity in the polymer backbone, resulting in a twisted ICT effect that can induce high PA signals. Further results show that the PTT-ATQ has good biocompatibility and high in vivo PA imaging performance within the NIR-II window. This work highlights the effective strategy to realize high-performance NIR-II in vivo PA imaging SP contrast agents by using the cost-effective thiophene-based building blocks.

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Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Cited by 32 publications

References 226 publications

BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Aggregation-Enhanced Photophysical Performance of D-π-A Structured Hemicyanine for NIR-II Fluorescent and Photoacoustic Imaging-Guided Photothermal Therapy

A Cost-Effective Semiconducting Polymer with an Ether Chain-Substituted Bithiophene as the Donor Unit Enabling Effective NIR-II Photoacoustic Imaging

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