Biomedical Positron Emission Tomography (PET) imaging

Chua, Sue; Groves, Ashley M.

doi:10.1533/9780857097477.1.3

Cited by 6 publications

(5 citation statements)

References 119 publications

(127 reference statements)

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“…Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) employ radiopharmaceuticals to provide three-dimensional images of the tracer molecules. , Both imaging techniques have the capability to track chemical changes, such as sugar metabolism and antisense recognition, with significant depth penetration. The distinction lies in the detection mechanism: in PET, two oppositely directed photons are detected by the scanner, which offers picomolar sensitivity but is constrained by the limited availability of imaging reagents, such as 18 F. In SPECT, however, the detectors can capture γ rays emitted from various radiolabeled tracers with a corresponding decrease in imaging precision …”

Section: Imaging-assisted Aso Delivery and Cancer Gene Therapymentioning

confidence: 99%

Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy

Liao,

Wang,

Wang

et al. 2024

Chemical & Biomedical Imaging

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Antisense oligonucleotide (ASO) represents a class of practical tools for targeting undruggable oncogenes with several candidates currently undergoing clinical investigation. The advancement of antisense therapeutics necessitates comprehensive approaches for evaluating their efficacy and improving their accuracy. Molecular imaging techniques offer a qualitative and quantitative means to assess therapeutics at the molecular, cellular, and in vivo levels, as well as to elucidate biodistribution and pharmacokinetics. These capabilities play a pivotal role in enhancing therapeutic evaluation and efficiency. This review systematically explores the current landscape of ASO delivery by leveraging a synergistic combination of imaging techniques and delivery vehicles to enhance oligonucleotide distribution and accumulation at tumor sites and thereby optimizing therapeutic outcomes.

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Section: Imaging-assisted Aso Delivery and Cancer Gene Therapymentioning

confidence: 99%

Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy

Liao,

Wang,

Wang

et al. 2024

Chemical & Biomedical Imaging

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“…Next, the Hamiltonian for the system is considered 1 . The electrostatic potential of the ground-state hydrogen atom is (see, e.g., Ref.…”

Section: One-particle Problemmentioning

confidence: 99%

“…The aim of this paper is to explore a numerically frugal method of including important electron-positron correlations in the calculations of positron (e + ) scattering from atoms and molecules. A good understanding of positron interactions with matter is a crucial element in the development of current and future applications of antimatter [1,2]. It is also important for tests of quantum electrodynamics [3] and fundamental experiments with antihydrogen [4].…”

Section: Introductionmentioning

confidence: 99%

Calculation of Low-Energy Positron-Atom Scattering with Square-Integrable Wavefunctions

Gregg

Gribakin

2022

Atoms

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The variational method is applied to the low-energy positron scattering and annihilation problem. The ultimate aim of the investigation is to find a computationally economical way of accounting for strong electron–positron correlations, including the effect of virtual positronium formation. The method is applied to the study of elastic s-wave positron scattering from a hydrogen atom. A generalized eigenvalue problem is set up and solved to obtain s-wave positron–hydrogen scattering phase shifts within 8×10−3 rad of accepted values. This is achieved using a small number of terms in the variational wavefunction; in particular, only nine terms that depend on the electron–positron distance are included. The annihilation parameter Zeff is also calculated and is found to be in good agreement with benchmark calculations.

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“…Positron emission tomography (PET) is a uniquely valuable molecular imaging modality for noninvasively exploring physiology and biochemistry in health and disease 1 , 2 , and has an expanding role in drug development 3 and medical diagnosis 4 . PET has notable importance for neuropsychiatric research both for the study of pathophysiology and for drug development.…”

Section: Introductionmentioning

confidence: 99%

Development of a non-radiometric method for measuring the arterial input function of a 11C-labeled PET radiotracer

Shetty

Zoghbi

Morse

et al. 2020

Sci Rep

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Positron emission tomography (PET) uses radiotracers to quantify important biochemical parameters in human subjects. A radiotracer arterial input function (AIF) is often essential for converting brain PET data into robust output measures. For radiotracers labeled with carbon-11 (t1/2 = 20.4 min), AIF is routinely determined with radio-HPLC of blood sampled frequently during the PET experiment. There has been no alternative to this logistically demanding method, neither for regular use nor validation. A 11C-labeled tracer is always accompanied by a large excess of non-radioactive tracer known as carrier. In principle, AIF might be obtained by measuring the molar activity (Am; ratio of radioactivity to total mass; Bq/mol) of a radiotracer dose and the time-course of carrier concentration in plasma after radiotracer injection. Here, we implement this principle in a new method for determining AIF, as shown by using [11C]PBR28 as a representative tracer. The method uses liquid chromatography-tandem mass spectrometry for measuring radiotracer Am and then the carrier in plasma sampled regularly over the course of a PET experiment. Am and AIF were determined radiometrically for comparison. The new non-radiometric method is not constrained by the short half-life of carbon-11 and is an attractive alternative to conventional AIF measurement.

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Biomedical Positron Emission Tomography (PET) imaging

Cited by 6 publications

References 119 publications

Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy

Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy

Calculation of Low-Energy Positron-Atom Scattering with Square-Integrable Wavefunctions

Development of a non-radiometric method for measuring the arterial input function of a 11C-labeled PET radiotracer

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