Biomedical potential of Anabaena variabilis NCCU-441 based Selenium nanoparticles and their comparison with commercial nanoparticles

Abstract

Selenium nanoparticles (SeNPs) are gaining importance in the field of medicines due to their high surface area and unique properties than their other forms of selenium. In this study, biogenic selenium nanoparticles (B-SeNPs) were synthesized using cyanobacteria and their bioactivities (antioxidant, antimicrobial, anticancer and biocompatibility) were determined for comparison with commercially available chemically synthesized selenium nanoparticles (C-SeNPs). Color change of reaction mixture from sky blue to orange-red indicated the synthesis of biogenic SeNPs (B-SeNPs). UV–Vis spectra of the reaction mixture exhibited peak at 266 nm. During optimization, 30 °C of temperature, 24 h of time and 1:2 concentration ratio of sodium selenite and cell extract represented the best condition for SeNPs synthesis. Various functional groups and biochemical compounds present in the aqueous extract of Anabaena variabilis NCCU-441, which may have possibly influenced the reduction process of SeNPs were identified by FT-IR spectrum and GC–MS. The synthesized cyanobacterial SeNPs were orange red in color, spherical in shape, 10.8 nm in size and amorphous in nature. The B-SeNPs showed better anti-oxidant (DPPH, FRAP, SOR and ABTS assays), anti-microbial (antibacterial and antifungal) and anti-cancer activitities along with its biocompatibility in comparison to C-SeNPs suggesting higher probability of their biomedical application.

The Potency of Fungal-Fabricated Selenium Nanoparticles to Improve the Growth Performance of Helianthus annuus L. and Control of Cutworm Agrotis ipsilon

“…These data are matched with Rajkumar et al [48], showing the successful formation of amorphous Se-NPs by Pseudomonas stutzeri strain MH191156 with observed small peaks in XRD pattern at 2θ values of 23 • , 26 • , and 40 • . The amorphous structure of green synthesized Se-NPs are reported previously, such as those synthesized by fruit extract of Emblica officinalis [47], Bacillus cereus [9], Alternaria alternata [49], and Anabaena variabilis strain NCCU-441 [50].…”

Biologically synthesized black ginger-selenium nanoparticle induces apoptosis and autophagy of AGS gastric cancer cells by suppressing the PI3K/Akt/mTOR signaling pathway

“…However, KP-SeNPs did not exhibit any sharp peaks, as the nanospherical sample was amorphous in character. Such SeNPs are also synthesized by many other plants as well as bacteria [ 30 , 31 ]. In the EDX spectrum, the optical absorption peaks at 1.8 keV corresponded to selenium peak (Fig.…”

Voyage of selenium from environment to life: Beneficial or toxic?

“…[ 80 ] In a very recent report, formation of selenium nanoparticles was reported with aqueous extract of Anabaena variabilis NCCU‐441. [ 81 ] In vitro formation of Se‐NP is also reported with plant extracts from Withania somnifera , lemon plant, walnut leaves and Capsicum annum . [ 82–84 ]…”