Biomedical Processing of Polyhydroxyalkanoates

Puppi, Dario; Pecorini, Gianni; Chiellini, Emo

doi:10.3390/bioengineering6040108

Cited by 64 publications

(54 citation statements)

References 97 publications

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“…Some examples of the monomeric units for scl-PHAs include: 3-hydroxybutyrate (3HB), 4-hydroxybutyrate (4HB), or 3-hydroxyvalerate (3HV). The scl-PHA materials have thermoplastic properties similar to that of polypropylene [6]. As PHB contains a methyl group in its chemical structure, it is the most prominent representative of the scl-PHA group.…”

Section: Polyhydroxyalkanoates (Phas)mentioning

confidence: 99%

“…For example, the Tm of PHA copolymers can be adjusted by changing the ratios of the monomers used for polymerization. When the percentage of 3 HV added to produce PHA copolymers is increased from 0 to 25 mol% [37], the Tm and the degree of crystallinity can be decreased without significantly impacting the Tg and Td, consequently widening the process window and improving the melt processability [6]. The incorporation of additional units of 3 HV has also been shown to improve the impact strength, however this is also accompanied by a reduction in tensile strength and modulus [38].…”

Section: Polyhydroxybutyrate (Phb)mentioning

confidence: 99%

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Production of Polyhydroxybutyrate (PHB) and Factors Impacting Its Chemical and Mechanical Characteristics

et al. 2020

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Plastic pollution is fueling the grave environmental threats currently facing humans, the animal kingdom, and the planet. The pursuit of renewable resourced biodegradable materials commenced in the 1970s with the need for carbon neutral fully sustainable products driving important progress in recent years. The development of bioplastic materials is highlighted as imperative to the solutions to our global environment challenges and to the restoration of the wellbeing of our planet. Bio-based plastics are becoming increasingly sustainable and are expected to substitute fossil-based plastics. Bioplastics currently include both, nondegradable and biodegradable compositions, depending on factors including the origins of production and post-use management and conditions. Among the most promising materials being developed and evaluated is polyhydroxybutyrate (PHB), a microbial bioprocessed polyester belonging to the polyhydroxyalkanoate (PHA) family. This biocompatible and non-toxic polymer is biosynthesized and accumulated by a number of specialized bacterial strains. The favorable mechanical properties and amenability to biodegradation when exposed to certain active biological environments, earmark PHB as a high potential replacement for petrochemical based polymers such as ubiquitous high density polyethylene (HDPE). To date, high production costs, minimal yields, production technology complexities, and difficulties relating to downstream processing are limiting factors for its progression and expansion in the marketplace. This review examines the chemical, mechanical, thermal, and crystalline characteristics of PHB, as well as various fermentation processing factors which influence the properties of PHB materials.

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Section: Polyhydroxyalkanoates (Phas)mentioning

confidence: 99%

Section: Polyhydroxybutyrate (Phb)mentioning

confidence: 99%

Production of Polyhydroxybutyrate (PHB) and Factors Impacting Its Chemical and Mechanical Characteristics

et al. 2020

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“…To this end, PHA's physical, thermomechanical, and processing properties are linked to the requirements of processing techniques conventionally employed to process plastics, such as solvent casting or melt-spinning, and to advanced, currently emerging manufacturing techniques, such as electrospinning or additive manufacturing (3D-printing). Key publications on different aspects affecting the workability of differently composed PHA homo-and copolyesters are summarized [22].…”

Section: Individual Contributionsmentioning

confidence: 99%

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

Koller

2020

Bioengineering

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During the two years that have passed since the first volume of “Advances in Polyhydroxyalkanoate (PHA) production” was published, the progress in PHA-related research was indeed tremendous, calling for the next, highly bioprocess- and bioengineering-oriented volume. This editorial paper summarizes and puts into context the contributions to this second volume of the Bioengineering Special Issue; it covers highly topical fields of PHA-related R&D activities, covering, beside the pronounced bioengineering-related articles, the fields of the microbiology of underexplored, but probably emerging, PHA production strains from the groups of Pseudomonas, cyanobacteria, methanotrophs, and from the extremophilic domain of haloarchaea. Moreover, novel second-generation lignocellulose feedstocks for PHA production from agriculture to be used in biorefinery concepts, new approaches for fine-tuning the composition of PHA co- and terpolyesters, process simulation for PHA production from methane-rich natural gas, the challenges associated with rheology-governed oxygen transfer in high cell density cultivations, rapid spectroscopic in-line analytics for process monitoring, and the biomedical application of PHA biopolyesters after appropriate advanced processing are the subjects of the presented studies.

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“…Due to nontoxicity, biodegradability, and biocompatibility, these PHB (poly(3-hydroxybutyrate)) and PLA blends can be useful together with three-dimensional (3D) printing technologies, especially for biomedicine (implants, scaffolds), art, archeology (replicas), and for prototyping and manufacture of reserve parts for the automotive industry, airplanes, etc. [ 12 , 18 , 19 , 20 ]. While PLA has great printability and is commonly used in 3D printing, printability of pure PHB (synthesized by bacterial fermentation) is more complicated due to its high crystallinity.…”

Section: Introductionmentioning

confidence: 99%

Printability, Mechanical and Thermal Properties of Poly(3-Hydroxybutyrate)-Poly(Lactic Acid)-Plasticizer Blends for Three-Dimensional (3D) Printing

et al. 2020

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This paper investigates the effect of plasticizer structure on especially the printability and mechanical and thermal properties of poly(3-hydroxybutyrate)-poly(lactic acid)-plasticizer biodegradable blends. Three plasticizers, acetyl tris(2-ethylhexyl) citrate, tris(2-ethylhexyl) citrate, and poly(ethylene glycol)bis(2-ethylhexanoate), were first checked whether they were miscible with poly(3-hydroxybutyrate)-poly(lactic acid) (PHB-PLA) blends using a kneading machine. PHB-PLA-plasticizer blends of 60-25-15 (wt.%) were then prepared using a corotating meshing twin-screw extruder, and a single screw extruder was used for filament preparation for further three-dimensional (3D) fused deposition modeling (FDM) printing. These innovative eco-friendly PHB-PLA-plasticizer blends were created with a majority of PHB, and therefore, poor mechanical properties and thermal properties of neat PHB-PLA blends were improved by adding appropriate plasticizer. The plasticizer also influences the printability of blends, which was investigated, based on our new specific printability tests developed for the optimization of printing conditions (especially printing temperature). Three-dimensional printed test samples were used for heat deflection temperature measurements and Charpy and tensile-impact tests. Plasticizer migration was also investigated. The macrostructure of 3D printed samples was observed using an optical microscope to check the printing quality and printing conditions. Tensile tests of 3D printed samples (dogbones), as well as extruded filaments, showed that measured elongation at break raised, from 21% for non-plasticized PHB-PLA reference blends to 84% for some plasticized blends in the form of filaments and from 10% (reference) to 32% for plasticized blends in the form of printed dogbones. Measurements of thermal properties (using modulated differential scanning calorimetry and oscillation rheometry) also confirmed the plasticizing effect on blends. The thermal and mechanical properties of PHB-PLA blends were improved by the addition of appropriate plasticizer. In contrast, the printability of the PHB-PLA reference seems to be slightly better than the printability of the plasticized blends.

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Biomedical Processing of Polyhydroxyalkanoates

Cited by 64 publications

References 97 publications

Production of Polyhydroxybutyrate (PHB) and Factors Impacting Its Chemical and Mechanical Characteristics

Production of Polyhydroxybutyrate (PHB) and Factors Impacting Its Chemical and Mechanical Characteristics

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

Printability, Mechanical and Thermal Properties of Poly(3-Hydroxybutyrate)-Poly(Lactic Acid)-Plasticizer Blends for Three-Dimensional (3D) Printing

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