Biomedical Waste Management: An Assessment of Knowledge, Attitude and Practice among Healthcare Workers in Tertiary Care Hospital, Chhattisgarh

Self Cite

Antimicrobial peptides (AMPs) represent a promising class of naturally occurring molecules with diverse structures and functions, offering a potent defense mechanism against microbial pathogens. This review explores the multifaceted role of AMPs in combating infections and their potential applications in various fields, including medicine, agriculture, and biotechnology. We discuss the mechanisms of action of AMPs, their structural diversity, modes of synthesis, and recent advancements in enhancing their stability and efficacy. Furthermore, we highlight the therapeutic potential of AMPs in treating multidrug-resistant infections, their role as alternatives to conventional antibiotics, and their applications in wound healing, immunomodulation, and drug delivery systems. Additionally, we examine the challenges associated with the clinical translation of AMPs and propose strategies to overcome these hurdles. Overall, this review underscores the importance of AMPs as versatile antimicrobial agents and emphasizes their potential to address the growing threat of antibiotic resistance.

Section: Applications Of Ampsmentioning

confidence: 99%

Harnessing the potential of antimicrobial peptides: current advances and future applications

Singh,

Sherwani,

Bhange

2024

Self Cite

“…One of them is antimicrobial peptides. 18 These substances belong to diverse group of molecules and present in every organism, they have capability to modulate immune system and they also can kill bacteria by attacking their membrane directly. They are also the part of first line of defense in many eukaryotic organisms.…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Rising antibiotic resistance: growing concern

Singh,

Bange

2023

Self Cite

In the 20th century, antibiotics were regarded as a "wonder drug," but due to overuse, bacteria have become resistant to them, giving rise to highly resistant superbugs that can live in the presence of drugs intended to stop them from multiplying. There are several mechanisms behind antimicrobial resistance. Antibiotic resistance can typically be acquired by drug-susceptible bacteria by genetic mutation or gene transfer, with horizontal gene transfer (HGT). Antibiotic resistance can be prevented by using them targeted in their least concentration. Making nano biomolecules could improve antimicrobial therapy's effectiveness and address problems with current methods of infection control. Antimicrobial peptides, bacteriophage therapy, probiotic therapy, and the use of phytochemicals are all essential antibiotic alternatives that should be employed to limit antibiotic consumption. Implementing new regulations, reviving research projects, and pursuing crisis management strategies all require coordinated efforts.

“…[12][13][14] Biomedical waste is a big source of infection in hospital setting and its surroundings which also give rise to associated infections. 15 Granulocytopenia lasting more than three weeks is the most common risk factor for developing invasive pulmonary Aspergillosis in patients with acute leukemia. 16 Transplant recipients with a liver, lung, heart, or kidney have both shared and distinct risk factors for the development of Invasive Aspergillosis.…”

Section: Association Of Pulmonary Aspergillosis With Other Health Con...mentioning

confidence: 99%

Pulmonary aspergillosis: infection, diagnosis and treatment

Singh,

Bange

2023

Self Cite

Pulmonary Aspergillosis is a group of lung disorder occurs due to the infection of Aspergillus species. It has wide range of clinical indications based on the interaction of Aspergillus with the host. The understanding of pathophysiological mechanism of Aspergillus infection is essential in order to minimize the chances of infection as well as to develop treatment strategies. Aspergillosis is found to be associated with various health conditions such as Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic fibrosis. The chances of Aspergillus infection increased in the transplant patient and the patient having immunocompromised state. Diagnosis is mostly done through sputum culture, serological and molecular diagnostic tools. Antifungal therapeutics is considered as treatment strategies along with monoclonal anti Immunoglobulin E (IgE) antibody. In some cases surgery is also preferred.