Biomedicinals from the phytosymbionts of marine invertebrates: A molecular approach

Dunlap, Walter C.; Battershill, Christopher N.; Liptrot, Catherine H.; Cobb, Rosemary E.; Bourne, David G.; Jaspars, Marcel; Long, Paul F.; Newman, David J.

doi:10.1016/j.ymeth.2007.03.001

Cited by 75 publications

(65 citation statements)

References 137 publications

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“…29) Alphaproteobacteria is the dominant group in the metagenomic library, followed by Actinobacteria and Cyanobacteria (Table 2). Various natural products have been isolated from Alphaproteobacteria, Actinobacteria, and Cyanobacteria, [30][31][32] and some might be the biogenic source of the non-ribosomal peptides. 32) This suggests that the metagenomic DNA, from which the eukaryotic genome had clearly been eliminated, is a promising genetic resource for the discovery of natural products by functional screening, and that heterologous expression of metagenomic DNA using a multi-host expression system might be useful for exploiting sponges' symbiotic bacteria efficiently.…”

Section: Discussionmentioning

confidence: 99%

Construction of a Metagenomic Library for the Marine SpongeHalichondria okadai

Abe

Sahin

Akiyama

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Construction of a Metagenomic Library for the Marine SpongeHalichondria okadai

Abe

Sahin

Akiyama

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…An increasing number of marine biosynthetic pathways are being cloned and characterized. Complementing this is a dramatic increase in the number and diversity of marine genome and metagenome sequences (93)(94)(95). In principle, this genetic sequence information can be used to identify diagnostic peptide fragments from putative biosynthetic enzymes that can be liberated by protease digestion and localized by subsequent MALDI imaging.…”

Section: Discussionmentioning

confidence: 99%

Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblages

Simmons

Coates

Clark

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

199

181

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In all probability, natural selection began as ancient marine microorganisms were required to compete for limited resources. These pressures resulted in the evolution of diverse genetically encoded small molecules with a variety of ecological and metabolic roles. Remarkably, many of these same biologically active molecules have potential utility in modern medicine and biomedical research. The most promising of these natural products often derive from organisms richly populated by associated microorganisms (e.g., marine sponges and ascidians), and often there is great uncertainty about which organism in these assemblages is making these intriguing metabolites. To use the molecular machinery responsible for the biosynthesis of potential drug-lead natural products, new tools must be applied to delineate their genetic and enzymatic origins. The aim of this perspective is to highlight both traditional and emerging techniques for the localization of metabolic pathways within complex marine environments. Examples are given from the literature as well as recent proof-of-concept experiments from the authors' laboratories.

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“…The demand for information on chemical and microbial ecology essentially comes from applied disciplines. Since many microbial symbionts were found to produce bioactive compounds that can be used for their biotechnological potential, microbe-sponge interactions have attracted increasing attention from applied research (Wang 2006, Dunlap et al 2007, Egan et al 2008, and the ecological perspectives of these associations have even become essential to gain an understanding of how those bioactive metabolites are produced (Taylor et al 2007). Hence, applied microbiology (i.e.…”

Section: Sponge Chemical and Microbial Ecology: Past Present And Futurementioning

confidence: 99%

Publication impact in sponge chemical and microbial ecology

Sacristán-Soriano

Becerro²

2016

Sci. Mar.

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Summary:It is well known that sponges constitute one of the most prevalent groups in marine benthic communities based on their challenging structural organization, abundance and diversity, and their functional roles in natural communities. The evolutionary success of this group may be explained by the close interaction between sponges and microbes, which dates back to the Precambrian era. This particular symbiosis has become a key factor within sponge research and is an emerging topic of two scientific disciplines: chemical and microbial ecology. This mini-review evaluates the influence of these two disciplines on the general scientific community using a series of bibliometric indicators to ensure objectivity. Our analyses showed that, although sponge chemical ecology has a greater overall impact on the scientific community, both disciplines are cited equally and more frequently than expected. Both research areas show a great impact on applied sciences, but the ecological perspectives of sponge chemistry and microbiology may fall outside the interests of a broader ecological audience. Moreover, we highlight some research topics (e.g. effects of environmental stress) that may require further attention. Hence, sponge chemical and microbial ecology have the opportunity to contribute to broader ecological issues in topics that make sponges particularly important, such as symbiosis.Keywords: Porifera research; natural products; microbiology; symbiosis; h-index; bibliometric indicators. Impacto de las publicaciones en ecología química y microbiana de esponjasResumen: Las esponjas constituyen uno de los grupos predominantes en las comunidades bentónicas marinas gracias a su potencial organización estructural, abundancia, diversidad y a las funciones que desempeñan en las comunidades naturales. El éxito evolutivo de este grupo yace en la estrecha interacción con microorganismos que data del Precámbrico. Esta particular simbiosis se ha convertido en un factor clave en la investigación sobre esponjas y está emergiendo en dos campos como el de la ecología química y microbiana. Esta mini-revisión evalúa la influencia de estas dos disciplinas en la comunidad científica utilizando una serie de indicadores bibliométricos para asegurar la objetividad. Nuestro análisis muestra que aunque la ecología química presenta un mayor impacto global, ambos campos son citados de manera similar y con una frecuencia superior a la esperada. Ambas áreas presentan un gran impacto en ciencias aplicadas, pero las perspectivas ecológicas de las dos disciplinas científicas deben quedar fuera de los intereses generales de la comunidad de ecólogos. Además, señalamos algunas áreas (e.g. efectos del estrés ambiental) que necesitarían mayor atención. Por tanto, la ecología química y microbiana de esponjas tienen la oportunidad de contribuir sobre cuestiones de ecología general con temas que las hace particularmente relevantes, como es la simbiosis.Palabras clave: investigación en Porifera; productos naturales; microbiología; simbiosis; índice h; indicad...

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Biomedicinals from the phytosymbionts of marine invertebrates: A molecular approach

Cited by 75 publications

References 137 publications

Construction of a Metagenomic Library for the Marine SpongeHalichondria okadai

Construction of a Metagenomic Library for the Marine SpongeHalichondria okadai

Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblages

Publication impact in sponge chemical and microbial ecology

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