Aging is a multi-factorial and very complex process, involving several deleterious changes that increase the risk of diseases that affect cells and tissues. 1,2 Aging is a gradual process of structural weakening, and its clinical effects begin to appear in the third decade of life lasting for life. 3 In the skin, aging is the result of the exposome, contemplating the combination and interaction of chronological, environmental, genetic, and hormonal factors. [3][4][5] Intrinsic aging, also known as chronological aging, occurs due to human physiological and chronological aging over time and is determined by genetic predisposition and mainly regulated by hormones such as androgens. 1,3 Genetic factors contribute to various biochemical, histological, and physiological changes. 3