The Internet of Things (IoT) is revolutionizing the healthcare industry by enhancing personalized patient care. However, the transmission of sensitive health data in IoT systems presents significant security and privacy challenges, further exacerbated by the difficulty of exploiting traditional protection means due to poor battery equipment and limited storage and computational capabilities of IoT devices. The authors analyze techniques applied in the medical context to encrypt sensible data and deal with the unique challenges of resource‐constrained devices. A technique that is facing increasing interest is the Physical Unclonable Function (PUF), where biometrics are implemented on integrated circuits' electric features. PUFs, however, demand special hardware, so in this work, instead of considering the physical device as a source of randomness, an ElectroCardioGram (ECG) can be taken into consideration to make a ‘virtual’ PUF. Such an mechanism leverages individual ECG signals to generate a cryptographic key for encrypting and decrypting data. Due to the poor stability of the ECG signal and the typical noise existing in the measurement process for such a signal, filtering and feature extraction techniques must be adopted. The proposed model considers the adoption of pre‐processing techniques in conjunction with a fuzzy extractor to add stability to the signal. Experiments were performed on a dataset containing ECG records gathered over 6 months, yielding good results in the short term and valuable outcomes in the long term, paving the way for adaptive PUF techniques in this context.