Biometry of the Corpus Callosum in Children: MR Imaging Reference Data

Garel, Catherine; Cont, I.; Alberti, Corinne; Josserand, Emilie; Moutard, M.L.; Pointe, Hubert Ducou Le

doi:10.3174/ajnr.a2542

Cited by 98 publications

(135 citation statements)

References 30 publications

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“…The typical adult, bulbous appearance of the 2 corpus callosum components was apparent by about 8 months. Within the time frame of the first postnatal year, the measurements of genu, body, and splenium thickness as well as overall corpus callosal length were similar to the measurements of the present study ( Table 2 ) [19] . In addition, the ratios of corpus callosum length to cerebral hemisphere length were almost identical in both studies (0.36-0.40) (see below).…”

Section: Discussionsupporting

confidence: 70%

“…Thus, the genu expands to a greater extent than the splenium during early development, while the splenium expands to a greater extent during later development. The results indicate an anterior to posterior wave of corpus callosal enlargement during human maturation [19] . The later, more protracted expansion of the splenium compared to the genu likely reflects the greater extent of myelination in the splenial component [21] .…”

Section: Discussionmentioning

confidence: 80%

“…Cerebral hemispheric areas were calculated for scaling purposes from previously published data [18] . The abbreviations described below are defined in Table 1 Cerebral hemispheric volume was calculated from the averages of 3 lengths (SCL, FCP, ACL), 3 widths (AFQ, ASQ, ATQ), and 2 heights (SFQ, SCH) according to the elliptical equation with a linear regression adjustment [19] .…”

Section: Calculation Of Corpus Callosal Areas and Shapesmentioning

confidence: 99%

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Development of the Corpus Callosum: An MRI Study

2016

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The size and shape of the corpus callosum and its major components (genu, body, and splenium) were measured by magnetic resonance imaging (MRI) in 118 normocephalic individuals aged from 1 postnatal week to 18.7 years. Genu, body, splenial, and total corpus callosal areas increased by 40-100% during the first year of life (p < 0.05). The genu expanded to a greater extent than the splenium during the first 6 years, while the splenium expanded to a greater extent between 7 and 18 years. The age-related difference in the maximal expansion of these structures indicated an anterior to posterior wave of corpus callosal enlargement during maturation, probably the consequence of differential axonal myelination. No sex differences existed during these two developmental phases for the genu, splenial, or total corpus callosal areas with or without scaling to the cerebral hemispheric volume. During infancy (0-24 months), however, the mean female splenial ratio (length/height) of 0.79 was greater than the male ratio of 0.65 (p = 0.024). The cerebral hemispheric length/height ratio was also greater in females, indicating that during infancy the female brain (and its component the corpus callosal splenium) is relatively longer than the male brain. This sex difference was confined to the splenium and disappeared with increasing age.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 80%

Section: Calculation Of Corpus Callosal Areas and Shapesmentioning

confidence: 99%

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Development of the Corpus Callosum: An MRI Study

2016

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“…In both subjects, there was hypoplasia of the isthmus and splenium of the corpus callosum with thickness falling below the third percentile reported for individuals of the same age [40]. As is often the case with callosal hypoplasia, there was associated dysmorphic configuration of the lateral ventricles and mild lateral ventriculomegaly without positive findings of abnormal CSF dynamics (i.e.…”

Section: A Clinical Evaluations and Phenotypic Presentationmentioning

confidence: 92%

A variant inTAF1is associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features

Lyon

2015

Preprint

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We describe the discovery of a new genetic syndrome, RykDax syndrome, driven by a whole genome sequencing (WGS) study of one family from Utah with two affected male brothers, presenting with severe intellectual disability (ID), a characteristic intergluteal crease, and very distinctive facial features including a broad, upturned nose, sagging cheeks, downward sloping palpebral fissures, prominent periorbital ridges, deep-set eyes, relative hypertelorism, thin upper lip, a high-arched palate, prominent ears with thickened helices, and a pointed chin. This Caucasian family was recruited from Utah, USA. Illumina-based WGS was performed on 10 members of this family, with additional Complete Genomics-based WGS performed on the nuclear portion of the family (mother, father and the two affected males). Using WGS datasets from 10 members of this family, we can increase the reliability of the biological inferences with an integrative bioinformatic pipeline. In combination with insights from clinical evaluations and medical diagnostic analyses, these DNA sequencing data were used in the study of three plausible genetic disease models that might uncover genetic contribution to the syndrome. We found a 2 to 5-fold difference in the number of variants detected as being relevant for various disease models when using different sets of sequencing data and analysis pipelines. We derived greater accuracy when more pipelines were used in conjunction with data encompassing a larger portion of the family, with the number of putative de-novo mutations being reduced by 80%, due to false negative calls in the parents. The boys carry a maternally inherited missense variant in a X-chromosomal gene TAF1, which we consider as disease relevant. TAF1 is the largest subunit of the general transcription factor IID (TFIID) multi-protein complex, and our results implicate mutations in TAF1 as playing a critical role in the development of this new intellectual disability syndrome.

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“…The latest achievements in the development of knowledge about the structure and function of brain and its separate structural ensembles, including commissural connections between them are mainly conditioned by qualitatively new methods of magnetic-resonance tomography [1][2][3][4][5], which technology can measure cerebral activity, determining the associated changes in blood flow that is based on the common conception that neuron activation in any cerebral zone is attended by the local rise of blood flow. At the same time this effect depends on the level of blood oxygenation [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The Features of Blood Supply of Corpus Callosum and the Structure of Its Hemomicrocirculatory Channel

Боягина

2017

EUREKA: Health Sciences

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Today we know the location of the sources of arterial blood delivery to the corpus callosum and we can approximately say, where are situated the venous vessels that the blood outflows from it to, but it is absolutely unknown, what is the intermediate link – the blood microcirculatory channel. Aim of research. The aim of our research is in identification of the ways of venous outflow from corpus callosum and in clarification of the principle of structural organization of its hemomicrocirculatory channel. Materials and methods. In the work are used the median total preparations of the corpus callosum (together with septum pellucidum and cerebral fornix formations) of 10 men 36–60 years old. Histological paraffin sections, colored by hematoxylin and eosin and according to Van-gieson were made of these preparations, and the methods of plastination of the corpus callosum tissues in epoxy resin with further creation of polished sections of different width and serial fine sections of blocs, for which coloration served the 1 % solution of blue methene for 1% borax solution, were also used. Results. It was established, that the arterial microvessels, starting from vascular plexus that covers the upper surface of corpus callosum, penetrate it as arterioles along interfunicular connective tissue septs that divide its commissural funicles between them. The arterioles are prolonged directly in venous microvessels that can be related to gathering venules. These direct microvascular communications, coming through the thickness of corpus callosum, can be named perforating arteriolovenular anastomoses. The aforesaid collector venules, localized in the lowest sections of interfunicular interlayers, are the direct inflows of venous channel of septum pellucidum. In general system of blood supply of corpus callosum the main arteries on the one side and the veins of septum pellucidum – on the other, are not accompanied by the vessels of opposite type. Conclusions. The blood microcirculatory channel of corpus callosum is the complexly branched in its thickness net of resistive, metabolic and capacitive microvessels, placed on the running way between arterial channel of soft cerebral tunic that covers the upper surface of corpus callosum and collector veins of septum pellucidum, situated below it. The direct shunting tracts between them are perforating arteriolovenular anastomoses.

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Biometry of the Corpus Callosum in Children: MR Imaging Reference Data

Abstract: BACKGROUND AND PURPOSE:The availability of data relating to the biometry of the CC in children that are easy to use in daily practice is limited. We present a reference biometry of the CC in MR imaging in a large cohort of children.

Cited by 98 publications

References 30 publications

Development of the Corpus Callosum: An MRI Study

Development of the Corpus Callosum: An MRI Study

A variant inTAF1is associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features

The Features of Blood Supply of Corpus Callosum and the Structure of Its Hemomicrocirculatory Channel

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