Biometry of the hypospadic penis after hormone therapy (testosterone and estrogen): A randomized, double-blind controlled trial

Paiva, Kelly Christina de Castro; Bastos, André Netto; Miana, Laura Pimenta; Barros, Eveline de Souza; Ramos, Plínio dos Santos; Miranda, Lara Meneguelli; Faria, Natália Maia; Figueiredo, André Avarese de; Bessa, José de; Netto, José Murillo Bastos

doi:10.1016/j.jpurol.2016.04.013

Cited by 27 publications

(21 citation statements)

References 24 publications

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“…Paiva et al reported the relative response of 69 children exposed to a placebo cream, T cream and estrogen cream. 18 While they did identify a response in patients receiving T, they did not provide absolute numbers for their cohorts. Ishii et al reported a significant increase in penile length for 17 boys in response to preoperative IM T injection.…”

Section: Discussionmentioning

confidence: 99%

Quantifying Glans Width Changes in Response to Preoperative Androgen Stimulation in Patients Undergoing Hypospadias Repair

et al. 2022

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Purpose:Testosterone (T) administration prior to hypospadias surgery to increase glans size remains controversial. Understanding T’s effect on glans width (GW) is essential to understanding its potential impact on surgical outcomes. We hypothesized that preoperative T in prepubertal boys significantly increases GW at the time of hypospadias surgery.Materials and Methods:Our single institutional database was queried to identify patients who underwent hypospadias surgery from 2016 to 2020, in which data for T administration and GW were available. Descriptive, nonparametric and categorical statistics were performed as indicated.Results:A total of 579 patients were eligible for analysis. Median age at surgery was 0.9 years (IQR 0.6–1.6). A total of 247/579 patients (42.7%) received T. The median GW at surgery was 15 mm (IQR 13–17). When comparing patients who had T administered to those who did not, we found a significant difference in GW at surgery (16 mm vs 14 mm, p <0.001). The median change in GW from the office to surgery was 4 mm for those receiving T vs 0 mm for those not receiving T (p <0.001). We identified a greater change in GW from preoperative to intraoperative measurements in patients who received 2 doses of T vs 1 dose (4 mm vs 2 mm, p <0.001). A histogram plot revealed the distribution of GW change at surgery.Conclusions:In our prospectively collected cohort of patients undergoing hypospadias surgery, we were able to quantitate the change in GW from preoperative T. Two doses of T resulted in a significant increase in GW vs 1 dose.

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Section: Discussionmentioning

confidence: 99%

Quantifying Glans Width Changes in Response to Preoperative Androgen Stimulation in Patients Undergoing Hypospadias Repair

et al. 2022

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“…This is likely technical in nature owing to the placement of undue tension on the glans closure, leading to glans dehiscence, meatal stenosis, and/or urethral stricture, although the exact etiology has yet to be elucidated. Supplemental testosterone increases glans width prior to surgery, potentially reducing this risk 35 – 37 . Although a recent report disputed the significance of glans size and risk of complication 38 , 39 , smaller glans size presents a challenge in the operating room.…”

Section: Factors Contributing To a High Complication Ratementioning

confidence: 99%

Proximal hypospadias: we aren’t always keeping our promises

Long

Canning

2016

F1000Res

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Hypospadias surgery is a humbling art form. The evolution of surgical techniques has made distal hypospadias outcomes favorable, but recent publications suggest that our complication rates for proximal hypospadias are much higher than previously reported. To explain these shortcomings, we examine the literature and focus on the lack of standardized documentation, the subsequent inability to objectify the severity of the phenotype, and the underestimation of complications due to lack of long-term follow up. The variability in surgical technique and the fact that the literature abounds with small case series from single institutions also limits our ability to compare outcomes. We believe that the use of standardized and scored phenotype assessments from diagnosis through the extended postoperative period will allow for improved scientific assessment of outcomes. This will facilitate multi-institution collaboration and tabulation of outcomes, allowing rapid data accumulation and assessment for this rare disorder. As surgeons, we must follow boys through puberty into adulthood and must honestly report our results in order to advance our surgical approach to this complicated problem.

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“…При дефиците пластического материала, гипоплазии крайней плоти и малых размерах полового члена ряд авторов использует препараты тестостерона в виде мазевых аппликаций, что достоверно приводит к временному увеличению крайней плоти и полового члена в целом [44].…”

Section: методы хирургического леченияunclassified

Hypospadias repair in children: fundamental principles and latest tendencies

Суров¹,

Kagantsov²

2017

Androl. genit. hir.

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В статье содержится анализ литературы, посвященной вопросам лечения гипоспадии у детей. Проводятся параллели между классическими трудами и современными тенденциями в лечении данного порока развития половых органов. Описаны новые хирургические методики (с отсылкой к истории их появления) и разработки. Ведется дискуссия об использовании одномоментных и этапных хирургических вмешательств при проксимальной гипоспадии, приводится анализ литературных данных об осложнениях, сопутствующих применению той или иной техники. Описываются новые варианты классификации гипоспадии, методы оценки тяжести порока до операции, варианты в косметической оценке после операции. Уделяется внимание такому направлению, как стандартизация подходов к хирургическому лечению гипоспадии, унификация методов уретропластики и коррекции искривления полового члена. Приводятся данные клинических исследований по использованию различных оперативных техник. Дается представление о стандартизации методов описания клинических исследований в сфере гипоспадологии.

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Biometry of the hypospadic penis after hormone therapy (testosterone and estrogen): A randomized, double-blind controlled trial

Cited by 27 publications

References 24 publications

Quantifying Glans Width Changes in Response to Preoperative Androgen Stimulation in Patients Undergoing Hypospadias Repair

Quantifying Glans Width Changes in Response to Preoperative Androgen Stimulation in Patients Undergoing Hypospadias Repair

Proximal hypospadias: we aren’t always keeping our promises

Hypospadias repair in children: fundamental principles and latest tendencies

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