Biomimetic Amphiphiles and Vesicles

Himmelein, Sabine; Ravoo, Bart Jan

doi:10.1002/9781118310083.ch8

Cited by 2 publications

(1 citation statement)

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“…Preparation of nanostructured polymer materials templated by self-assembled scaffolds has long been inspired by biosynthetic machinery on cell membranes, − but it still remains a challenging subject of research in laboratories. − Noticing that one of the fundamental problems in this challenge is the excessive fluidity of a lipid or lipid-mimetic membrane, , we conjectured on the use of a self-assembled bilayer made of an anionic fullerene amphiphile (Figure a; 1 – 4 ; R = n C 8 F 17 , n C 8 H 17 , n C 20 H 41 , H), from which an aqueous solution of a vesicle of a uniform size (typically 30 nm in diameter) is formed spontaneously upon dissolution in water ( V1 – V4 , respectively) . The fullerene bilayer keeps the hydrophilic fullerene anion inside and exposes the hydrophobic groups to an aqueous environment to create three regions: surface, interior, and fullerene-rich core (Figure b, left).…”

Section: Introductionmentioning

confidence: 99%

Nanoscale Control of Polymer Assembly on a Synthetic Catalyst–Bilayer System

2016

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The use of the interior of self-assembled membrane as a template for polymer synthesis and assembly has long attracted the interest of chemists. However, it is difficult to utilize a lipid membrane as a chemical reactor for controlled assembly for polymers because lipid membrane is easily destabilized by loading of extraneous molecules. We found that a several-nanometer-thick bilayer vesicle made by self-assembly of an organic fullerene amphiphile doped with a metathesis catalyst serves as a nanosized chemical reactor in water, where a polymer is synthesized and assembled, depending on the affinity of the growing polymer to the organic groups on the amphiphile. This catalyst-bilayer system can thus control supramolecular assembly of the ester-functionalized polymer product into different nanoscale structures: a nanoparticle made of a single polymer chain and a nanocapsule made of several tens of polymer chains.

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Section: Introductionmentioning

confidence: 99%

Nanoscale Control of Polymer Assembly on a Synthetic Catalyst–Bilayer System

2016

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Therapeutic Nanoreactors as In Vivo Nanoplatforms for Cancer Therapy

Mukerabigwi

Kataoka

2018

Chemistry A European J

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Therapeutic nanoreactors have been proposed as nanoplatforms to treat diseases through in situ production of therapeutic agents. When this treatment strategy is applied in cancer therapy, it can efficiently produce highly toxic anticancer drugs in situ from low-toxic prodrugs or some biomolecules in tumor tissues, which can maximize the therapeutic efficacy with a significantly low systemic toxicity. An ideal therapeutic nanoreactor can provide the reaction space, protect the loaded fragile catalysts, target the desired pathological site, and be selectively activated. In this minireview, we highlight the recent advances concerning the applications of therapeutic nanoreactors as in vivo nanoplatforms particularly in cancer therapy. Herein, the therapeutic nanoreactors are discussed on the basis of treatment strategies and various nanoparticles. Specifically, the treatment strategies of nanoreactors including single enzyme, single enzyme with chemodrugs, and multienzymes, as well as varying types of engineered nanoparticle-loaded active catalysts, primarily including liposomes, polymersomes, polymeric micelles, inorganic nanoparticles, and metal-organic framework (MOF) architectures, are documented and briefly discussed. Finally, we elucidate the current challenges to be addressed toward further development and translation into clinical applications of these therapeutic nanoreactors in cancer therapy.

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Biomimetic Amphiphiles and Vesicles

Cited by 2 publications

References 78 publications

Nanoscale Control of Polymer Assembly on a Synthetic Catalyst–Bilayer System

Nanoscale Control of Polymer Assembly on a Synthetic Catalyst–Bilayer System

Therapeutic Nanoreactors as In Vivo Nanoplatforms for Cancer Therapy

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