Biomimetic Amphiphiles: Properties and Potential Use

Mehta, Shalina; Sharma, Shweta; Mehta, Neena; Cameotra, Swaranjit Singh

doi:10.1007/978-1-4419-5979-9_8

Cited by 10 publications

(22 citation statements)

References 34 publications

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“…The payload stability of the nanovesicles was tested for the first time in human serum. The data indicate that one of the newly synthesized JDs (JDG0G1 (3,5)) form dendrimersomes with a greater stability than its higher generation precursor, as only a small percentage (ca. 25%) of Gadoteridol was released in the presence of serum.…”

Section: Discussionmentioning

confidence: 97%

“…The synthesis and characterization of (3,4)12G1-PE-BMPA-G2-(OH) 8 and (3,5)12G1-PE-BMPA-G2-(OH) 8 Janus dendrimers (JDG1G2(3,4) and JDG1G2 (3,5) in Fig. 1) were performed as described elsewhere.…”

Section: Synthesis Of Janus Dendrimersmentioning

confidence: 99%

“…3,4 Liposomes are the best-known example of artificial nanosized vesicles, and consist of a phospholipid bilayer entrapping an aqueous core. 5,6 They are successfully used for a number of biomedical purposes: from model systems to study biological membranes to efficient vectoring carriers for delivering bioactive substances or other molecules to pathological sites.…”

Section: Introductionmentioning

confidence: 99%

“…Thanks to these distinctive features, JDG1G2(3,5)-based dendrimersomes possess a good diagnostic and theranostic potential. In this contribution, two novel low-generation isomeric JDs (coded JDG0G1 (3,4) and JDG0G1 (3,5)) bearing only one hydrophobic and one hydrophilic dendron linked together by an ethylene glycol residue ( Fig. 1) have been synthesized.…”

Section: Introductionmentioning

confidence: 99%

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Novel stable dendrimersome formulation for safe bioimaging applications

et al. 2015

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a Dendrimersomes are nanosized vesicles constituted by amphiphilic Janus dendrimers (JDs), which have been recently proposed as innovative nanocarriers for biomedical applications. Recently, we have demonstrated that dendrimersomes self-assembled from (3,5)12G1-PE-BMPA-G2-(OH) 8 dendrimers can be successfully loaded with hydrophilic and amphiphilic imaging contrast agents. Here, we present two newly synthesized low generation isomeric JDs: JDG0G1(3,5) and JDG0G1(3,4). Though less branched than the above-cited dendrimers, they retain the ability to form self-assembled, almost monodisperse vesicular nanoparticles. This contribution reports on the characterization of such nanovesicles loaded with the clinically approved MRI probe Gadoteridol and the comparison with the related nanoparticles assembled from more branched dendrimers. Special emphasis was given to the in vitro stability test of the systems in biologically relevant media, complemented by preliminary in vivo data about blood circulation lifetime collected from healthy mice. The results point to very promising safety and stability profiles of the nanovesicles, in particular for those made of JDG0G1(3,5), whose spontaneous self-organization in water gives rise to a homogeneous suspension. Importantly, the blood lifetimes of these systems are comparable to those of standard liposomes. By virtue of the reported results, the herein presented nanovesicles augur well for future use in a variety of biomedical applications.

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Section: Discussionmentioning

confidence: 97%

Section: Synthesis Of Janus Dendrimersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel stable dendrimersome formulation for safe bioimaging applications

et al. 2015

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“…Biomimetic materials capable of reproducing the architecture and properties of native biological membranes are attracting much interest in the field of biomedical sciences . Some natural or synthetic amphiphiles can simulate the behavior of cell membrane components by self‐assembling into organized structures in aqueous environments . Self‐assembled structures formed by amphiphiles vary from simple micelles to highly organized large aggregates such as fibers, tubes, and helices, and are increasingly used in material chemistry, nanotechnology, and medicinal chemistry .…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembly Behavior and Application of Terphenyl‐Cored Trimaltosides for Membrane‐Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability

Ehsan

Mortensen

et al. 2019

Chemistry A European J

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Amphipathic agents are widely used in various fields including biomedical sciences. Micelle‐forming detergents are particularly useful for in vitro membrane‐protein characterization. As many conventional detergents are limited in their ability to stabilize membrane proteins, it is necessary to develop novel detergents to facilitate membrane‐protein research. In the current study, we developed novel trimaltoside detergents with an alkyl pendant‐bearing terphenyl unit as a hydrophobic group, designated terphenyl‐cored maltosides (TPMs). We found that the geometry of the detergent hydrophobic group substantially impacts detergent self‐assembly behavior, as well as detergent efficacy for membrane‐protein stabilization. TPM‐Vs, with a bent terphenyl group, were superior to the linear counterparts (TPM‐Ls) at stabilizing multiple membrane proteins. The favorable protein stabilization efficacy of these bent TPMs is likely associated with a binding mode with membrane proteins distinct from conventional detergents and facial amphiphiles. When compared to n‐dodecyl‐β‐d‐maltoside (DDM), most TPMs were superior or comparable to this gold standard detergent at stabilizing membrane proteins. Notably, TPM‐L3 was particularly effective at stabilizing the human β2 adrenergic receptor (β2AR), a G‐protein coupled receptor, and its complex with Gs protein. Thus, the current study not only provides novel detergent tools that are useful for membrane‐protein study, but also suggests a critical role for detergent hydrophobic group geometry in governing detergent efficacy.

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Effects of Surface Active Additives on the Enzymatic Treatment of Phenol and Its Derivatives: a Mini Review

Alshabib

Onaizi

2019

Curr Pollution Rep

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Biomimetic Amphiphiles: Properties and Potential Use

Cited by 10 publications

References 34 publications

Novel stable dendrimersome formulation for safe bioimaging applications

Novel stable dendrimersome formulation for safe bioimaging applications

Self‐Assembly Behavior and Application of Terphenyl‐Cored Trimaltosides for Membrane‐Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability

Effects of Surface Active Additives on the Enzymatic Treatment of Phenol and Its Derivatives: a Mini Review

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