Biomimetic anti-inflammatory nano-capsule serves as a cytokine blocker and M2 polarization inducer for bone tissue repair

Yin, Chengcheng; Zhao, Qin; Li, Wu; Zhao, Zifan; Wang, Jinyang; Deng, Tian; Zhang, Peng; Shen, Kailun; Li, Zubing; Zhang, Yufeng

doi:10.1016/j.actbio.2019.11.025

Cited by 100 publications

(58 citation statements)

References 43 publications

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“…Yin et al designed a “cytokine blocker” (BANC) constructed with LPS-stimulated macrophages cell membranes enveloping gold nanocages, to neutralise pro-inflammatory cytokines by the overexpressed cytokine receptors on cell membrane ( Fig. 2 A and 2B) [ 121 ]. Besides, resolvin D1, an anti-inflammatory drug, was pre-loaded into the nanocages to facilitate M2 polarisation.…”

Section: Harnessing the Power Of Macrophages For Enhanced Osteogenesimentioning

confidence: 99%

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Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches

Niu

Wang

Shi

et al. 2021

Bioactive Materials

132

123

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A coordinated interaction between osteogenesis and osteoimmune microenvironment is essential for successful bone healing. In particular, macrophages play a central regulatory role in all stages of bone repair. Depending on the signals they sense, these highly plastic cells can mediate the host immune response against the exterior signals of molecular stimuli and implanted scaffolds, to exert regenerative potency to a varying extent. In this article, we first encapsulate the immunomodulatory functions of macrophages during bone regeneration into three aspects, as sweeper, mediator and instructor. We introduce the phagocytic role of macrophages in different bone healing periods (‘sweeper’) and overview a variety of paracrine cytokines released by macrophages either mediating cell mobilisation, vascularisation and matrix remodelling (‘mediator’), or directly driving the osteogenic differentiation of bone progenitors and bone repair (‘instructor’). Then, we systematically classify and discuss the emerging engineering strategies to recruit, activate and modulate the phenotype transition of macrophages, to exploit the power of endogenous macrophages to enhance the performance of engineered bone tissue.

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Section: Harnessing the Power Of Macrophages For Enhanced Osteogenesimentioning

confidence: 99%

“…Reprinted with permission from Ref. [ 121 , 123 ], Copyright (2020) Elsevier and Copyright (2018) American Chemical Society. …”

Section: Harnessing the Power Of Macrophages For Enhanced Osteogenesimentioning

confidence: 99%

Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches

Niu

Wang

Shi

et al. 2021

Bioactive Materials

132

123

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show abstract

“…Yin et al . 22 provided another strategy to fabricate a biomimetic anti‑inflammatory nanocapsule (BANC). The BANC is coated with lipopolysaccharide-treated macrophage cell membranes, loading resolvin D1 inside a gold nanocage as an “M2 polarization inducer”.…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, several studies have demonstrated that NIR light triggered mild localized heat, and the photoelectronic microenvironment could accelerate bone tissue regeneration 19 , 20 . Moreover, NIR light-responsive drug delivery systems have not only been used for targeted cancer therapies, but also for the delivery of growth factors for bone tissue regeneration 21 , 22 . These latest studies have revealed that NIR light‑assisted phototherapy is likely to realize more precise and less invasive therapeutic solutions not only for bone cancers, but also for implant infections, osteochondral inflammation, and bone tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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“…[20] In the case of the implants for tissue regeneration purposes, immunohistological staining of the implant-surrounding tissues can be performed to evaluate the level of the inflammation, e.g. by staining arginase 1 (ARG1) [21] (Figure 3). Otherwise, the levels of inflammatory cytokines, i.e., IL-1 , IL-6, and TNF-, in the surrounding tissues can be determined.…”

Section: Evaluation Of Inflammatory Response To Biomaterialsmentioning

confidence: 99%

Recent Advances in Antiinflammatory Material Design

Lebaudy

Fournel

Lavalle

et al. 2020

Adv Healthcare Materials

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Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.

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Biomimetic anti-inflammatory nano-capsule serves as a cytokine blocker and M2 polarization inducer for bone tissue repair

Cited by 100 publications

References 43 publications

Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches

Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Recent Advances in Antiinflammatory Material Design

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