Biomimetic Approaches in Clinical Endodontics

Abstract

In the last few decades, biomimetic concepts have been widely adopted in various biomedical fields, including clinical dentistry. Endodontics is an important sub-branch of dentistry which deals with the different conditions of pulp to prevent tooth loss. Traditionally, common procedures, namely pulp capping, root canal treatment, apexification, and apexigonesis, have been considered for the treatment of different pulp conditions using selected materials. However, clinically to regenerate dental pulp, tissue engineering has been advocated as a feasible approach. Currently, new trends are emerging in terms of regenerative endodontics which have led to the replacement of diseased and non-vital teeth into the functional and healthy dentine-pulp complex. Root- canal therapy is the standard management option when dental pulp is damaged irreversibly. This treatment modality involves soft-tissue removal and then filling that gap through the obturation technique with a synthetic material. The formation of tubular dentine and pulp-like tissue formation occurs when stem cells are transplanted into the root canal with an appropriate scaffold material. To sum up tissue engineering approach includes three components: (1) scaffold, (2) differentiation, growth, and factors, and (3) the recruitment of stem cells within the pulp or from the periapical region. The aim of this paper is to thoroughly review and discuss various pulp-regenerative approaches and materials used in regenerative endodontics which may highlight the current trends and future research prospects in this particular area.

Biomimetic approaches and materials in restorative and regenerative dentistry: review article

“…Cell homing strategies for dental tissue regeneration was introduced in 2010, representing a viable approach for tissue regeneration [93]. It involves recruitment of stem or progenitor cells in order to achieve tissue regeneration and revascularization by chemotaxis via biological signalling molecules [94].…”

Topology Optimization of a Femoral Stem in Titanium and Carbon to Reduce Stress Shielding with the FEM Method

“…The dynamic load of the average walk is applied to the femoral stem from which they were taken [25]. In further analysis, the load deriving from a monopodalic support is also considered [26]. Any type of torsional, rotational, or tensile force is not considered, and the distal end areas are kept fixed (Figure 4).…”

“…deriving from a monopodalic support is also considered [26]. Any type of torsional, rotational, or tensile force is not considered, and the distal end areas are kept fixed (Figure 4).…”

In Vitro Evaluation of the Effect of Oleanolic Acid as a Potential Root Canal Medicament on Viability and Proliferation of Dental Pulp Stem Cells

“…17 Moreover, the quick decomposition of Ca(OH) 2 presents difficulties by preventing the formation of critical soft tissue needed for appropriate tooth differentiation in the canal space. 18,19 The increasing popularity of herbal remedies in dentistry and medicine is driven by their biocompatibility, heightened antibacterial activity, and antioxidant and anti-inflammatory properties. Herbal medicine's rapid growth is attributed to its medicinal benefits, accessibility, and minimal side effects.…”

“…17 Moreover, the quick decomposition of Ca(OH) 2 presents difficulties by preventing the formation of critical soft tissue needed for appropriate tooth differentiation in the canal space. 18 19…”